Patents by Inventor Marcel Jozefowicz
Marcel Jozefowicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7101863Abstract: The invention concerns pharmaceutical compositions with wound healing or anti-complementary activity, and their uses, said compositions comprising, (1) at least a dextran derivative of general formula DMCaBbSuc, a, b, and c respectively representing the degrees of substitution in the groups MC, B and Su, wherein a?0.6, b=0 or ?0.1, and c=0 or ranges widely between 0.1 and 0.5 for a wound healing composition, and a?0.3, b?0.1 and c=0 or ranges widely between 0.1 and 0.4 for a composition with anti-complementary activity; (2) and at least a pharmaceutically acceptable carrier, said dextran derivative being present in a single unit dose or at a concentration adapted to the desired wound healing or anti-complementary activity.Type: GrantFiled: December 13, 2001Date of Patent: September 5, 2006Assignee: BiodexInventors: Latifa Dahricorreia, Jacqueline Jozefonvicz, Marcel Jozefowicz, José Correia, Rémi Huynh
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Patent number: 6946443Abstract: The invention concerns a biologically active material essentially comprising at least an insolubilized dextran derivative of general formula DMCaBbSUcSd and at least a growth factor having an activity on osteoarticular, dental and/or maxillofacial tissues, and the method for preparing same. The invention also concerns the uses of said biomaterial for preparing a repair or filing material, such as an implant, for osteoarticular, dental or maxillofacial applications and for preparing an orthopaedic, dental or maxillofacial prosthesis, and the prosthesis coated with said biologically active material.Type: GrantFiled: December 11, 2001Date of Patent: September 20, 2005Assignee: BiodexInventors: Cinderella Blanchat, Delphine Logeart-Avramoglou, Hervé Petite, Alain Meunier, Frédéric Chaubet, Jacqueline Jozefonvicz, Marcel Jozefowicz, Laurent Sedel, José Correia
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Patent number: 6646120Abstract: The invention concerns dextran derivatives, their applications as medicines with specific biological action, and their preparation method. Said derivatives correspond to the general formula DMCaBbSUcSd, in which: D represents a polysaccharide chain, preferably consisting of sequences of glucoside units, MC represents methylcarboxylate groups, B represents carboxymethylbenzylamide groups, Su represents sulphate groups, S represents sulphonate groups, a, b, c and d represent the degree of substitution (ds), respectively in groups, MC, B, Su and S; a being equal to 0 or ≧0.3, b being equal to 0 or ≧0.1, c being equal to 0 or ≧0.1 and d being equal to 0 or ≧0.Type: GrantFiled: September 26, 2000Date of Patent: November 11, 2003Assignee: BiodexInventors: Frederic Chaubet, Remi Huynh, Latifa Dahri, Jose Correia, Marcel Jozefowicz, Jacqueline Jozefonvicz
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Publication number: 20020183282Abstract: The invention concerns pharmaceutical compositions with wound healing or anti-complementary activity, and their uses, said compositions comprising. (1) at least a dextran derivative of general formula DMCaBbSuc, a, b, and c respectively representing the degrees of substitution in the groups MC, B and Su, wherein a ≧0.6, b=0 or ≧0.1, and c=0 or ranges widely between 0.1 and 0.5 for a wound healing composition, and a≧0.3, b ≧0.1 and c=0 or ranges widely between 0.1 and 0.4 for a composition with anti-complementary activity; (2) and at least a pharmaceutically acceptable carrier, said dextran derivative being present in a single unit dose or at a concentration adapted to the desired wound healing or anti-complementary activity.Type: ApplicationFiled: December 13, 2001Publication date: December 5, 2002Inventors: Latifa Dahricorreia, Jacqueline Jozefonvicz, Marcel Jozefowicz, Jose Correia, Remi Huynh
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Publication number: 20020169120Abstract: The invention concerns a biologically active material essentially comprising at least an insolubilised dextran derivative of general formula DMCaBbSUcSd and at least a growth factor having an activity on osteoarticular, dental and/or maxillofacial tissues, and the method for preparing same. The invention also concerns the uses of said biomaterial for preparing a repair or filing material, such as an implant, for osteoarticular, dental or maxillofacial applications and for preparing an orthopaedic, dental or maxillofacial prosthesis, and the prosthesis coated with said biologically active material.Type: ApplicationFiled: December 11, 2001Publication date: November 14, 2002Inventors: Cinderella Blanchat, Delphine Logeart-Avramoglou, Herve Petite, Alain Meunier, Frederic Chaubet, Jacqueline Jozefonvicz, Marcel Jozefowicz, Laurent Sedel, Jose Correia
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Patent number: 6417000Abstract: The invention relates to water-insoluble polymers which promote cell proliferation, contain carboxylate and sulfonate groups and are obtainable by free radical copolymerization of one or more aliphatically unsaturated monomers containing carboxylate groups, or the correspondingly functionalized derivatives of the monomers, as component I with one or more aliphatically unsaturated monomers containing sulfonate groups, or the correspondingly functionalized derivatives of the monomers, as component II and a component III which comprises an aliphatically unsaturated monomer or several aliphatically unsaturated monomers, the correspondingly functionalized derivatives being converted into carboxylate and sulfonate groups after the copolymerization, and to a process for their preparation, wherein the polymers are useful for forming articles which promote cell proliferation.Type: GrantFiled: November 15, 2001Date of Patent: July 9, 2002Assignee: Le Groupement d'Intérét Public Thérapeutiques Substitutives Institut Galilée, Université Paris-NordInventors: Frank Hill, by Friedrich Frank Hill, by Regina Luise Hill, Peter Ottersbach, Graciella Djavid, Marcel Jozefowicz, Veronique Migonney, Jean-Pierre Vairon
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Publication number: 20020068804Abstract: The invention relates to water-insoluble polymers which promote cell proliferation, contain carboxylate and sulfonate groups and are obtainable by free radical copolymerization of one or more aliphatically unsaturated monomers containing carboxylate groups, or the correspondingly functionalized derivatives of the monomers, as component I with one or more aliphatically unsaturated monomers containing sulfonate groups, or the correspondingly functionalized derivatives of the monomers, as component II and a component III which comprises an aliphatically unsaturated monomer or several aliphatically unsaturated monomers, the correspondingly functionalized derivatives being converted into carboxylate and sulfonate groups after the copolymerization, and to a process for their preparation, wherein the polymers are useful for forming articles which promote cell proliferation.Type: ApplicationFiled: November 15, 2001Publication date: June 6, 2002Applicant: Le Groupement d'Interet Public Therapeutiques Substitutives Instinut GalileeInventors: Frank Hill, Hella Luise Hill, Henning Hinrich Hill, Friedrich Frank Hill, Regina Luise Hill, Peter Ottersbach, Graciella DJavid, Marcel Jozefowicz, Veronique Migonney, Jean-Pierre Vairon
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Patent number: 6365692Abstract: The invention relates to water-insoluble polymers which promote cell proliferation, contain carboxylate and sulfonate groups and are obtainable by free radical copolymerization of one or more aliphatically unsaturated monomers containing carboxylate groups, or the correspondingly functionalized derivatives of the monomers, as component I with one or more aliphatically unsaturated monomers containing sulfonate groups, or the correspondingly functionalized derivatives of the monomers, as component II and a component III which comprises an aliphatically unsaturated monomer or several aliphatically unsaturated monomers, the correspondingly functionalized derivatives being converted into carboxylate and sulfonate groups after the copolymerization, and to a process for their preparation, wherein the polymers are useful for forming articles which promote cell proliferation.Type: GrantFiled: December 30, 1997Date of Patent: April 2, 2002Assignee: Le Groupement d'Intérêt Public Thérapeutiques Subsitutives Institut Galilée, Université Paris-NordInventors: Frank Hill, Peter Ottersbach, Graciella Djavid, Marcel Jozefowicz, Veronique Migonney, Jean-Pierre Vairon
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Patent number: 6248811Abstract: A process is disclosed for preparing bioactive, covalently fixed coatings on the surfaces of substrates, by grafting to a surface of the substrate a coating polymer which contains the following monomers in copolymerized form: (i) at least one monomer of the general formula: R—(A)a (I), in which R is a mono- or diolefinically unsaturated organic radical having a valence a, A is a carboxyl group, a sulfuric acid group, a sulfonic acid group, a phosphoric acid group, a phosphonic acid group, a phosphorous acid group, a phenolic hydroxyl group, or a salt of one of these acid groups, and a is 1, 2 or 3; and (ii) at least one monomer which is sensitive to UV radiation.Type: GrantFiled: January 5, 1998Date of Patent: June 19, 2001Assignee: Huels AktiengesellschaftInventors: Peter Ottersbach, Britta Mensing, Gerard Helary, Marcel Jozefowicz, Veronique Migonney, Jean-Pierre Vairon
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Patent number: 6218492Abstract: The invention relates to water-insoluble, bacteriophobic and optionally cell proliferation-inhibiting polymers obtainable by free-radical polymerization of (a) at least one monomer of the general formula R—(A)a, in which R is an aliphatically unsaturated organic radical with the valence a, A is a carboxyl group —COOH, sulfuric acid group —OSO2OH, sulfonic acid group —SO3H, phosphoric acid group —OPO(OH)2, phosphonic acid group —PO(OH)2, phosphorous acid group —OP(OH)2, a phenolic hydroxyl group or a salt of one of the groups, and a is 1, 2 or 3, with the proviso that, if the monomer of the formula I contains a carboxyl group —COOH or a carboxylate group, either this monomer contains at least one further radical A having a different one of the definitions specified for A, or at least one further monomer of the formula I is also used in which A has a different one of the definitions specified for A; and (b) at least one other aliphatically unsaturated monomer, wheType: GrantFiled: April 24, 1998Date of Patent: April 17, 2001Assignee: Huels AktiengesellschaftInventors: Frank Hill, Peter Ottersbach, Graciella Djavid, Marcel Jozefowicz, Veronique Migonney, Jean-Pierre Vairon
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Patent number: 6160056Abstract: A process for preparing molding materials having anticoagulant properties is described. Hydrophobic monomers are subjected to free-radical copolymerization with hydrophilic monomers having biospecifically active functions to produce the molding material. The molding material may then be shaped into articles which also have anticoagulant properties. These articles are extremely useful in, for example, medical applications in contact with a patient's biological fluid.Type: GrantFiled: March 2, 1998Date of Patent: December 12, 2000Assignee: Vestolit GmbHInventors: Marcel Jozefowicz, Veronique Migonney, Heinz Hermann Meyer, Thomas Neu, Axel Stieneker, Christine Anders, Peter Ottersbach
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Patent number: 5019269Abstract: These resins derived from a crosslinked styrene (co)-polymer, or from a crosslinked dextran, comprise a (co)-polymer chain which is substituted with one or more groups, which may be identical or different, belonging to the following categories: --Z--A.sub.1 ; --Z--A.sub.2 ; --Z--A.sub.1 --Z'--A.sub.2 ; --Z--A.sub.1 --A.sub.3 --A.sub.2 ; --Z--A.sub.1 --A.sub.4, where Z=spacer chain, Z'=linking chain, A.sub.1 =phosphate residue, A.sub.2 =residue of purine or pyrimidine base, A.sub.3 =sugar residue and A.sub.4 =residue of a molecule participating in the polar structure of various phospholipids. These resins are applicable for the analysis and purification of molecules of biological origin, in particular as a stationary phase in ion-exchange and affinity chromatography, especially for carrying out the fractionation of protein mixtures.Type: GrantFiled: March 21, 1990Date of Patent: May 28, 1991Assignee: Centre National de la Recherche ScientifiqueInventors: Didier Letourneur, Colette Douzon, Veronique Migonney, Daniel A. Muller, Marcel Jozefowicz
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Patent number: 4950712Abstract: These resins derived from a crosslinked styrene (co)-polymer, or from a crosslinked dextran, comprise a (co)-polymer chain which is substituted with one or more groups, which may be identical or different, belonging to the following categories: --Z--A.sub.1 ; --Z--A.sub.2 ; --Z--A.sub.1 --Z'--A.sub.2 ; --Z--A.sub.1 --A.sub.3 --A.sub.2 ; --Z--A.sub.1 --A.sub.4, where Z=spacer chain, Z'=linking chain, A.sub.1 =phosphate residue, A.sub.2 =residue of purine or pyrimidine base, A.sub.3 =sugar residue and A.sub.4 =residue of a molecule participating in the polar structure of various phospholipids. These resins are applicable for the analysis and purification of molecules of biological origin, in particular as a stationary phase in ion-exchange and affinity chromatography, especially for carrying out the fractionation of protein mixtures.Type: GrantFiled: August 22, 1988Date of Patent: August 21, 1990Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Didier Letourneur, Colette Douzon, Veronique Migonney, Daniel A. Muller, Marcel Jozefowicz
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Patent number: 4945054Abstract: The present invention relates to a process for separating and purifying proteases and antiproteases. This process is characterized in that there are placed in contact an insoluble cross-linked polymer including in its chain the group --SO.sub.3 R.sub.1 -- and/or the group --SO.sub.2 R.sub.2 -- in which R.sub.1 denotes a hydrogen atom or metal and R.sub.2 denotes the remainder of an amino acid linked to the --SO.sub.2 -- bridge through its amine --NH--, function, with the solution containing proteases and antiproteases or their complex; separating the polymer which has absorbed the desired protein, washing it carefully with the buffer, desorbing the absorbed protein by a solution of a polycationic compound in the case of T or by an albumin solution in the case of AT or of the complex T-AT, and isolating the protein, if desired, by known means, such as, especially, freeze drying. The invention is useful for studying the mechanism of blood coagulation.Type: GrantFiled: May 17, 1983Date of Patent: July 31, 1990Assignee: Commissariat a l'Energie AtomiqueInventors: Christine Fougnot, Marcel Jozefowicz, Robert D. Rosenberg