Patents by Inventor Marcel Loetscher

Marcel Loetscher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100061983
    Abstract: The present invention relates to proteins or polypeptides, referred to herein as isolated and/Or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.
    Type: Application
    Filed: September 21, 2007
    Publication date: March 11, 2010
    Applicants: Millennium Pharmaceuticals, Inc., Theodor-Kocher Institute
    Inventors: Marcel Loetscher, Bernhard Moser, Shixin Qin, Charles R. Mackay
  • Patent number: 7407655
    Abstract: The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: August 5, 2008
    Assignees: Millennium Pharmaceuticals, Inc., Theodor-Kocher Institute
    Inventors: Marcel Loetscher, Bernhard Moser, Shixin Qin, Charles R. Mackay
  • Patent number: 7029862
    Abstract: The invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: April 18, 2006
    Assignee: Theodor-Kocher Institute
    Inventors: Marcel Loetscher, Bernhard Moser
  • Patent number: 6833439
    Abstract: The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: December 21, 2004
    Assignee: Theodor-Kocher-Institute
    Inventors: Marcel Loetscher, Bernhard Moser
  • Patent number: 6686175
    Abstract: The invention relates to isolated and/or recombinant nucleic acids encoding a mammalian (e.g., human) CXCR3 protein and variants thereof, including antisense nucleic acid, recombinant nucleic acid constructs, such as plasmids or retroviral vectors, comprising a nucleic acid which encodes a protein of the present invention or variant thereof, and to host cells comprising a nucleic acid or construct, useful in the production of recombinant proteins. The invention also relates to a method for producing a mammalian (e.g., human) CXCR3 protein.
    Type: Grant
    Filed: July 25, 2000
    Date of Patent: February 3, 2004
    Assignee: Theodor-Kocher Institute
    Inventors: Marcel Loetscher, Bernhard Moser
  • Publication number: 20030158392
    Abstract: The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.
    Type: Application
    Filed: September 20, 2002
    Publication date: August 21, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Marcel Loetscher, Bernhard Moser, Shixin Qin, Charles R. Mackay
  • Patent number: 6184358
    Abstract: The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen. Another aspect of the invention relates to isolated and/or recombinant nucleic acids encoding a mammalian (e.g., human) CXCR3 protein and variants thereof, including antisense nucleic acid, recombinant nucleic acid constructs, such as plasmids or retroviral vectors, comprising a nucleic acid which encodes a protein of the present invention or variant thereof, and to host cells comprising a nucleic acid or construct, useful in the production of recombinant proteins.
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: February 6, 2001
    Assignees: Millennium Pharmaceuticals, Inc., Theodor-Kocher Institute
    Inventors: Marcel Loetscher, Bernhard Moser, Shixin Qin, Charles R. Mackay
  • Patent number: 6140064
    Abstract: The present invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.
    Type: Grant
    Filed: September 10, 1996
    Date of Patent: October 31, 2000
    Assignee: Theodor-Kocher Institute
    Inventors: Marcel Loetscher, Bernhard Moser