Publication number: 20050209253
Abstract: An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. [Solution] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.
Type:
Application
Filed:
December 24, 2003
Publication date:
September 22, 2005
Inventors:
Atsuro Nakazato, Taketoshi Okubo, Dai Nozawa, Mikato Yamaguchi, Tomoko Tamita, Ludo Kennis, Marcel De Bruyn, Jean-Pierre Bongartz, Frans Van Den Keybus, Yves Van Roosbroeck, Marcel Luyckx, Robert Hendrickx