Abstract: An oncological, FAP-targeting pharmaceutical has the chemical structure: FAPi-R1-FAPs-CT with R1=formula (1) or formula (II) or formula (III), in which FAPi denotes an FAP inhibitor, FAPs denotes an FAP substrate, CT denotes a cytotoxin, MG denotes a labeling group for a radioisotope, TL denotes a tris linker, and L1, L2, L3, L4, L5, L6 denote bivalent linkers.

Abstract: The invention relates to a radiotracer labeling precursor includes a first target vector (TV1), a second target vector (TV2), a labeling group (MG) for complexation or covalent binding of a radioisotope, a first spacer (S1), a second spacer (S2), a third spacer (S3) and a trislinker (TL), as illustrated in the structure below:

Abstract: A device for calibrating a laser beam system includes a calibration member having a surface positioned at a predetermined distance from the base datum of the unit. Further, the system includes a mechanism for focusing the beam to a focal point and for moving the focal point relative to the surface of the calibration member. When the focal point reaches the surface of the calibration member, Laser Induced Optical Breakdown (LIOB) is induced. Thereafter, the position of the location of LIOB may be measured relative to the base datum to calibrate the laser beam. Further, patterns may be applied to the calibration member using LIOB to calibrate tilt/decenter of the beam and to determine the energy density and uniformity in the focal spot of the laser beam.

Abstract: In a fishing hook assembly of the type in which, in a first set condition, limbs of the assembly presenting hooks are restrained by a latch member which when actuated by a fish striking the assembly permits the limbs to move under the influence of resilient urging thereof to a second released condition in which the fish is snared by the hooks the actuation of the latch member is a pivotal movement thereof about an intermediate axis with the trigger of the latch member being moved towards the plane of movement of the hooks.