Patents by Inventor Marcel R. Pirio
Marcel R. Pirio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7179660Abstract: A polysaccharide coated carrier having a coating of at least two successive layers of polysaccharide. The first polysaccharide layer spontaneously associates with a second polysaccharide layer and, optionally, the carrier. Each successive layer of polysaccharide spontaneously associates with a preceding layer. Spontaneous association occurs due to the presence of oppositely charged functional groups on each layer of polysaccharide or due to a spontaneous reaction between the functional groups the layers. The carrier may be any surface such as a tube, microtitration plate, bead, particle or the like and is suitable for use in diagnostic or therapeutic methods.Type: GrantFiled: March 6, 2000Date of Patent: February 20, 2007Assignee: Dade Behring Marburg GmbHInventors: Hrair Kirakossian, John S. Pease, Carsten Schelp, Marcel R. Pirio, Uwe Stöhr, Andreas Wiegand
-
Patent number: 6326159Abstract: Receptors are disclosed that are antibodies that exhibit a binding affinity for an immune complex of a monoepitopic antigen and an antibody for such antigen that is substantially greater than the binding affinity for the monoepitopic antigen or the antibody for the monoepitopic antigen apart from the immune complex. Normally, the monoepitopic antigen has a molecular weight less than 1500 and is an organic compound. The antibodies of the present invention find use in a method for determining a monoepitopic antigen in a sample suspected of containing such antigen. The method comprises forming an immune sandwich complex comprising the monoepitopic antigen or an analog thereof, a first monoclonal antibody that binds to the monoepitopic antigen, and a second monoclonal antibody that is an antibody of the present invention and detecting the immune sandwich complex.Type: GrantFiled: September 2, 1994Date of Patent: December 4, 2001Assignee: Dade Behring Marburg GmbHInventors: Edwin F. Ullman, John Jelesko, Marcel R. Pirio, Thomas D. Kempe
-
Patent number: 5223441Abstract: Receptors are disclosed that are antibodies that exhibit a binding affinity for an immune complex of a monoepitopic antigen and an antibody for such antigen that is substantially greater than the binding affinity for the monoepitopic antigen or the antibody for the monoepitopic antigen apart from the immune complex. In one embodiment the receptors are antibodies prepared against an affinity-labeled complex of an antigen and an antibody for the antigen. Normally, the monoepitopic antigen has a molecular weight less than 1500 and is an organic compound. The antibodies of the present invention find use in a method for determining a monoepitopic antigen in a sample suspected of containing such antigen. The method comprises forming an immune sandwich complex comprising the monoepitopic antigen or an analog thereof, a first monoclonal antibody that binds to the monoepitopic antigen, and a second monoclonal antibody that is an antibody of the present invention and detecting the immune sandwich complex.Type: GrantFiled: October 9, 1986Date of Patent: June 29, 1993Assignee: Syntex (U.S.A.) Inc.Inventors: Edwin F. Ullman, John Jelesko, Marcel R. Pirio, Thomas D. Kempe
-
Patent number: 4772697Abstract: Tricyclic antidepressant functionalized compounds are provided for conjugation through a side chain to antigenic compounds, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies and together with the enzyme conjugates find particular use in immunoassays for the determination or detection of the total amount of tricyclic antidepressants present in a sample.Type: GrantFiled: August 21, 1986Date of Patent: September 20, 1988Assignee: Syntex (U.S.A.) Inc.Inventors: Christine G. Collins, Marcel R. Pirio, Prithipal Singh
-
Patent number: 4629691Abstract: Tricyclic antidepressant functionalized compounds are provided for conjugation through a side chain to antigenic compounds, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies and together with the enzyme conjugates find particular use in immunoassays for the determination or detection of the total amount of tricyclic antidepressants present in a sample.Type: GrantFiled: August 12, 1983Date of Patent: December 16, 1986Assignee: Syntex (U.S.A.) Inc.Inventors: Christine G. Collins, Marcel R. Pirio, Prithipal Singh
-
Patent number: 4551275Abstract: Desmethylimipramine functionalized compounds are provided for conjugation to antigenic compounds, particularly poly(amino acids) and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of desmethylimipramine, while the enzyme conjugate finds use in an enzyme assay for the determination of desmethylimipramine.Type: GrantFiled: March 23, 1984Date of Patent: November 5, 1985Assignee: Syntex (U.S.A.) Inc.Inventors: Marcel R. Pirio, Prithipal Singh
-
Patent number: 4329502Abstract: Compounds are provided which can be used in the preparation of reagents useful for quantitatively determining the presence of b-adrenergic blocking agents. These compounds contain a derivative of the blocking agent which is linked to an antigen or enzyme, the antigen conjugates being useful for preparing antibodies, and the enzyme conjugates being useful as detectors in an immunoassay as well. Additionally carboxylic acids, esters and aldehydes which are derivatives of the blocking agents are provided which are useful in preparing the above conjugates.Type: GrantFiled: August 7, 1980Date of Patent: May 11, 1982Assignee: Syva CompanyInventors: Prithipal Singh, Marcel R. Pirio
-
Patent number: 4275160Abstract: Imipramine functionalized compounds are provided for conjugation to antigenic compounds, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of imipramine, while the enzyme conjugate finds use in a homogeneous enzyme assay for the determination of imipramine.Type: GrantFiled: July 6, 1979Date of Patent: June 23, 1981Assignee: Syva CompanyInventors: Prithipal Singh, Marcel R. Pirio
-
Patent number: 4241177Abstract: Compounds are provided which can be used in the preparation of reagents useful for quantitatively determining the presence of .beta.-adrenergic blocking agents. These compounds contain a derivative of the blocking agent which is linked to an antigen or enzyme, the antigen conjugates being useful for preparing antibodies, and the enzyme conjugates being useful as detectors in an immunoassay as well. Additionally carboxylic acids, esters and aldehydes which are derivatives of the blocking agents are provided which are useful in preparing the above conjugates.Type: GrantFiled: August 28, 1978Date of Patent: December 23, 1980Assignee: Syva CompanyInventors: Prithipal Singh, Marcel R. Pirio
-
Patent number: 4235969Abstract: Compounds are provided for use in the preparation of reagents which can be used in immunoassays for the determination of benzamides of N,N-dialkylethyleneamines. A linking group is provided, at a particular site of the drug, which provides a link between the above compounds and an antigen, with the resulting conjugate being employed for the preparation of antibodies. The antibodies find particular use in competitive protein binding assays. Conjugates to enzymes are prepared which find particular use in homogeneous enzyme immunoassays.Type: GrantFiled: May 8, 1978Date of Patent: November 25, 1980Assignee: Syva CompanyInventors: Prithipal Singh, Marcel R. Pirio