Abstract: The present invention relates to synergistic combinations of DNA-alkylating ADCs and ATR inhibitors.

Abstract: Mono or bi-specific antibodies, antibody fragments, or fusion proteins thereof, are capable of binding to the VHL ligand degrading moiety (degron) of a proteolysis targeting chimera (PROTAC) and, optionally, to a target protein. Complexes (PAX) of such antibodies, antibody fragments, fusion proteins thereof, and PROTACS are also capable of. Methods for their production can be performed, and these antibodies have medical and non-medical uses.

Abstract: The present invention relates to antibodies comprising tags that can be covalently conjugated to the primary amino group of a linker in the presence of a microbial transglutaminase. Also provided by the invention are methods for producing an antibody-linker-conjugate by mixing an antibody with a linker and a microbial transglutaminase. Also provided are antibody-linker conjugates and antibody-drug-conjugates producible according to the inventive method and a kit of parts comprising a buffer and a microbial transglutaminase.

Abstract: An overpack cask for reversibly receiving, handling and transporting a repository container for spent nuclear material is disclosed, and the overpack cask comprises a tubular cask shell defining a receiving cavity for reversibly receiving a repository container therein, a first cask cover providing a sealing closure of the receiving cavity at a first axial end of the tubular cask shell and a second cask cover providing a sealing closure of the receiving cavity at a second axial end of the tubular cask shell opposite to the first axial end. At least the first cask cover is removable from the tubular cask shell to uncover a first opening of the tubular cask shell at the first axial end for loading and/or unloading a repository container into and from the receiving cavity, respectively.

Abstract: A device for the calorimetric determination of the decay heat power of fuel elements has a calorimeter container with a coolant inlet and a coolant outlet, a line system with a coolant removal line and a coolant supply line, a feed pump, a flow measuring device, a first temperature measuring device at the coolant inlet, a second temperature measuring device at the coolant outlet, and a closing cover.

Abstract: The present invention relates to synergistic combinations of DNA-alkylating ADCs and ATR inhibitors.

Abstract: The burner includes a swirl chamber. The swirl chamber has a substantially conical shape defining a central axis. The swirl chamber is defined by a plurality of wall elements. A combination of nozzles at the pressure, suction side and trailing edge of the wall element are placed for fuel injection. The wall elements define slots between each other. The slots have different widths (w) in consecutive planes in the axial direction, wherein said planes are perpendicular to the central axis.

Abstract: This invention relates to a premix burner for operating a heat generator, the burner at least having a swirl generator, a mixing section downstream of the swirl generator and a transition piece for transferring the swirl flow from the swirl generator into the mixing section. The invention further refers to a transition piece for such a premix burner. The transition piece includes an inlet, connected to the swirl generator, an outlet, connected to the mixing tube, and a continuing flow limiting interior contour between said inlet and said outlet, wherein at least in an inlet section said interior contour is curved radially inwards towards the inner diameter of the mixing tube and wherein at the outlet the interior contour is flush with an interior flow limiting contour of the mixing tube.

Abstract: The invention relates to a gas turbine power plant, having a gas turbine, a waste heat steam generator following the gas turbine, an exhaust gas recooler, an exhaust gas blower, a carbon dioxide separation plant which separates the carbon dioxide contained in the exhaust gases from these and discharges it to a carbon dioxide outlet. A bypass chimney is arranged in the gas turbine power plant between the outlet of the waste heat steam generator and the exhaust gas blower and is connected to a fail-safe open connection both in the throughflow direction from the exhaust gas line to the bypass chimney and in the throughflow direction from the bypass chimney to the exhaust gas line. The invention relates, further, to a method for operating a gas turbine power plant of this type, in which the exhaust gas blower is regulated.

Abstract: This invention relates to a premix burner for operating a heat generator, the burner at least having a swirl generator, a mixing section downstream of the swirl generator and a transition piece for transferring the swirl flow from the swirl generator into the mixing section. The invention further refers to a transition piece for such a premix burner. The transition piece includes an inlet, connected to the swirl generator, an outlet, connected to the mixing tube, and a continuing flow limiting interior contour between said inlet and said outlet, wherein at least in an inlet section said interior contour is curved radially inwards towards the inner diameter of the mixing tube and wherein at the outlet the interior contour is flush with an interior flow limiting contour of the mixing tube.

Abstract: A burner arrangement includes a tubular mixing tube extending along an axis and configured to mix fuel and air, the mixing tube opening into a combustion chamber in a direction of flow; and a film air ring disposed in the mixing tube and arranged concentrically to the axis, the film air ring configured to prevent a backfiring of the fuel disposed in the mixing tube and to generate or reinforce an air film near the wall, wherein the film air ring has at least one annular gap concentric to the axis and configured to inject air.

Abstract: A burner arrangement includes a tubular mixing tube extending along an axis and configured to mix fuel and air, the mixing tube opening into a combustion chamber in a direction of flow; and a film air ring disposed in the mixing tube and arranged concentrically to the axis, the film air ring configured to prevent a backfiring of the fuel disposed in the mixing tube and to generate or reinforce an air film near the wall, wherein the film air ring has at least one annular gap concentric to the axis and configured to inject air.