Abstract: An abrasive article including a base having an annular shape defining a central opening; and a mounting assembly coupled to the base, wherein a portion of the mounting assembly is under a compressive force, and a grinding segment coupled to the mounting member.

Abstract: An abrasive article including a base having an annular shape defining a central opening; and a mounting assembly coupled to the base, wherein a portion of the mounting assembly is under a compressive force, and a grinding segment coupled to the mounting member.

Abstract: An abrasive article includes a carrier element, an abrasive component, and a bonding region between the abrasive component and the carrier element. The abrasive component includes abrasive particles bound in a metal matrix. The abrasive component further includes a network of interconnected pores substantially filled with an infiltrant. The infiltrant has an infiltrant composition containing at least one metal element. The bonding region includes a bonding metal having a bonding metal composition containing at least one metal element. The bonding region is a region distinct from the carrier element and is a separate phase from the carrier element. An elemental weight percent difference is the absolute value of the difference in weight content of each element contained in the bonding metal composition relative to the infiltrant composition. The elemental weight percent difference between the bonding metal composition and the infiltrant composition does not exceed 20 weight percent.

Abstract: The present invention relates to N-containing heterocyclic compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2, JAK3 or TYK2 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

Abstract: A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein A represents a variety of six membered nitrogen containing heterocyclic rings, Q is a bond, halogen, C1-4 alkyl, O, S, SO2, CO or CS and X1, X2, X3 and X4 are optionally substituted by 9 specific substituents or one can be nitrogen. Compositions comprising a carrier and at least one compound of formula (I) are also provided. Further provided are methods of treating tyrosine kinase-associated disease states by administering a compound of formula (I) and methods of suppressing the immune system of a subject by administering a compound of formula (I).

Abstract: An abrasive article including a base having an annular shape defining a central opening; and a mounting assembly coupled to the base, wherein a portion of the mounting assembly is under a compressive force, and a grinding segment coupled to the mounting member.

Abstract: A relief valve in a turbomachine is disclosed. The valve includes a gate designed to be mounted so as to pivot about a shaft for the opening and closing of an orifice for the passage of air, a seal, and an attachment device for attaching the seal to the peripheral edge of the gate. The gate and the attachment device are made of a plastic and formed of a single piece or secured to one another by welding or bonding.

Abstract: A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating tyrosine kinase-associated disease states in a subject using a compound of formula (I) is also described.

Abstract: The present invention relates to N-containing heterocyclic compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2, JAK3 or TYK2 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

Abstract: A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein A represents a variety of six membered nitrogen containing heterocyclic rings, Q is a bond, halogen, C1-4 alkyl, O, S, SO2, CO or CS and X1, X2, X3 and X4 are optionally substituted by 9 specific substituents or one can be nitrogen. Compositions comprising a carrier and at least one compound of formula (I) are also provided. Further provided are methods of treating tyrosine kinase-associated disease states by administering a compound of formula (I) and methods of suppressing the immune system of a subject by administering a compound of formula (I).

Abstract: Abrasive tip for abrasive tool and method for forming and replacing thereof are disclosed. The abrasive tip facilitates easy and quick attachment to an abrasive tool.

Abstract: An abrasive article includes a carrier element, an abrasive component, and a bonding region between the abrasive component and the carrier element. The abrasive component includes abrasive particles bound in a metal matrix. The abrasive component further includes a network of interconnected pores substantially filled with an infiltrant. The infiltrant has an infiltrant composition containing at least one metal element. The bonding region includes a bonding metal having a bonding metal composition containing at least one metal element. The bonding region is a region distinct from the carrier element and is a separate phase from the carrier element. An elemental weight percent difference is the absolute value of the difference in weight content of each element contained in the bonding metal composition relative to the infiltrant composition. The elemental weight percent difference between the bonding metal composition and the infiltrant composition does not exceed 20 weight percent.

Abstract: The present invention provides a method of detecting an analyte in a sample with probe-modified electrodes and measuring an electrocatalytic signal generated by a binding of an analyte in the sample to a probe.

Abstract: Relief valve in a turbomachine, comprising a gate (116) designed to be mounted so as to pivot about a shaft (120) for the opening and closing of an orifice for the passage of air, a seal (152) and means (158) for attaching the seal to the peripheral edge of the gate, the gate and the attachment means being made of a plastic and formed of a single piece or secured to one another by welding or bonding.

Abstract: A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein A represents a variety of six membered nitrogen containing heterocyclic rings, Q is a bond, halogen, C1-4 alkyl, O, S, SO2, CO or CS and X1, X2, X3 and X4 are optionally substituted by 9 specific substituents or one can be nitrogen. Compositions comprising a carrier and at least one compound of formula (I) are also provided. Further provided are methods of treating tyrosine kinase-associated disease states by administering a compound of formula (I) and methods of suppressing the immune system of a subject by administering a compound of formula (I).

Abstract: The development of color of a concentrate of alkarylsulphonic acids is reduced by adding to and dissolving in the freshly prepared concentrate up to 5% of its weight of an organic compound having at least one ether group therein, the partial vapor pressure of the compound thus dissolved in the concentrate being negligible at the temperatures at which the concentrate is stored or transported. Examples of suitable organic compounds are aliphatic or phenolic monoethers, e.g. diethylene glycol.

Abstract: Oligomerizing propylene using a Friedel Crafts catalyst at a temperature in the range -10.degree. to 80.degree. C and hydrogenating the oligomer so obtained to produce oils useful as hydraulic fluids.

Abstract: A modular gas and liquid contact member is formed of a plurality of extended surface sheet members with means associated with at least the peripheral margins thereof warping the sheets and maintaining the sheets in an undulated array. In a preferred form of the invention, the means for warping and maintaining the sheet members in the undulated array comprises a plurality of through bolts and spacers of varying lengths threaded on the through bolts and contacting opposed surfaces of adjacent sheet members.

Abstract: A hardening fiber composition for use in the processing of photographic silver halide elements is described which contains a 1-hydroxy-alkylidene diphosphonic acid the alkylidene group of which contains from 2 to 5 C-atoms.

Abstract: Blends of paraffinic oils and hydrogenated polycyclopentadiene or polymethylcyclopentadiene.