Abstract: A method for cell stimulation by mechanical energy as well as a method for determining a subject specific set of treatment parameters for acoustic wave stimulation and a method for validating a set of treatment parameters for acoustic wave stimulation. The method for determining a subject specific set of treatment parameters includes generating subject specific data, which includes measuring a geometric property of a body portion, and determining a target field distribution in the body portion. The method for validating a set of treatment parameters for acoustic wave stimulation includes determining a target field distribution of an acoustic field in a body portion, receiving a related set of treatment parameters for at least one transducer, generating a subject specific 3D model of the body portion, and determining a difference between the target field distribution and a field distribution determined in the subject specific 3D model.

Abstract: A closure system (3) for closing an opening (25) of a container (2) comprises a stopper member (31), a cage member (32) and a lock activation formation (34). The stopper member (31) is made of an elastic material and has a plug portion (311) configured to fit into the opening (25) of the container (2) and a cover portion (312) configured to abut a boundary surface (24) adjacent to the opening (25) of the container (2). The cage member (32) is made of a shape-retentive material. The closure system (3) is configured to be in an assembled state in which the plug portion (311) of the stopper member (31) is fitted into the opening (25) of the container (2), the cover portion (312) of the stopper member (31) abuts the boundary surface (24) of the container (2) and the cage member (32) is mounted to the container (2).

Abstract: A closure system is disclosed for closing a container opening. The closure system includes a stopper member, a cage member for mounting to the container, and a spring member. The stopper member has a plug portion that tightly fits into the container opening and a cover portion that abuts a boundary surface adjacent to the container opening container. The stopper member plug portion is fitted into the container opening, the stopper member cover portion abuts the boundary surface of the container, and the cage member is mounted to the container to hold the stopper member, when the closure system is in an assembled state. The cage and spring members are arranged to position the spring member between the stopper member cover portion and the cage member such that the spring member pushes the cage member away from the cover portion when the closure system is in the assembled state.

Abstract: A closure system for closing a container opening is disclosed that includes a stopper member, a cage member for mounting to a container, a cover member reversibly mountable to the cage member, and an integrity visualization member. The stopper member has a plug portion to fit into the container opening and a cover portion to abut a boundary surface of the container opening. The plug portion of the stopper member is fitted into the opening of the container and the cage member is mounted to the container. The cage member applies a force to the cover portion to push the cover portion onto the boundary surface of the container opening. The cover member covers an aperture of the cage member when mounted to the cage member. The integrity visualization member indicates an integrity of the closure system and is positioned between the cover portion and the cage member.