Patents by Inventor Marcel Wuethrich

Marcel Wuethrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide MHCII tetramers to detect endogenous calnexin specific CD4 T cells
    Patent number: 11789019
    Abstract: The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: October 17, 2023
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Bruce Steven Klein, Marcel Wuethrich
  • Vaccine Adjuvant
    Publication number: 20210205445
    Abstract: A Dectin-2 ligand vaccine adjuvant and a method of making and using the Dectin-2 ligand vaccine adjuvant in a vaccine to immunize a patient are disclosed. Also discloses is a vaccine composition comprising a Bl-Eng2 antigen and methods of using the vaccine composition to immunize a subject against a fungal infection.
    Type: Application
    Filed: February 26, 2021
    Publication date: July 8, 2021
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Bruce Steven Klein, Huafeng Wang, Marcel Wuethrich, Tristan Theodore Brandhorst
  • Method of treating fungal infection
    Patent number: 10806776
    Abstract: A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: October 20, 2020
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Bruce Steven Klein, Theodore Tristan Brandhorst, Thomas Sullivan, Marcel Wuethrich
  • Peptide MHCII Tetramers to Detect Endogenous Calnexin Specific CD4 T Cells
    Publication number: 20190361022
    Abstract: The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).
    Type: Application
    Filed: August 1, 2019
    Publication date: November 28, 2019
    Inventors: Bruce Steven Klein, Marcel Wuethrich
  • Peptide MHCII tetramers to detect endogenous calnexin specific CD4 T cells
    Patent number: 10416158
    Abstract: The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: September 17, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bruce Steven Klein, Marcel Wuethrich
  • METHOD OF TREATING FUNGAL INFECTION
    Publication number: 20190000942
    Abstract: A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.
    Type: Application
    Filed: May 2, 2018
    Publication date: January 3, 2019
    Inventors: Bruce Steven Klein, Theodore Tristan Brandhorst, Thomas Sullivan, Marcel Wuethrich
  • Method of treating fungal infection
    Patent number: 9993534
    Abstract: A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: June 12, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bruce Steven Klein, Theodore Tristan Brandhorst, Thomas Sullivan, Marcel Wuethrich
  • Vaccine Adjuvant
    Publication number: 20180110853
    Abstract: A Dectin-2 ligand vaccine adjuvant and a method of making and using the Dectin-2 ligand vaccine adjuvant in a vaccine to immunize a patient are disclosed. Also discloses is a vaccine composition comprising a Bl-Eng2 antigen and methods of using the vaccine composition to immunize a subject against a fungal infection.
    Type: Application
    Filed: October 18, 2017
    Publication date: April 26, 2018
    Inventors: Bruce Steven Klein, Huafeng Wang, Marcel Wuethrich, Tristan Theodore Brandhorst
  • Peptide MHCII Tetramers to Detect Endogenous Calnexin Specific CD4 T Cells
    Publication number: 20150301044
    Abstract: The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).
    Type: Application
    Filed: March 10, 2015
    Publication date: October 22, 2015
    Inventors: Bruce Steven Klein, Marcel Wuethrich
  • Method of Treating Fungal Infection
    Publication number: 20140271720
    Abstract: A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Bruce Steven Klein, Theodore Tristan Brandhorst, Thomas Sullivan, Marcel Wuethrich
  • Global regulator of morphogenesis and pathogenicity in dimorphic fungi and uses thereof
    Patent number: 7888120
    Abstract: A method of screening a compound for anti-fungal properties comprising the steps of exposing a test compound to a fungal histidine kinase, and determining whether kinase activity is inhibited, wherein inhibition of kinase activity indicates that the compound has anti-fungal properties is disclosed.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: February 15, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bruce S. Klein, Julie C. Nemecek, Marcel Wuethrich
  • GLOBAL REGULATOR OF MORPHOGENESIS AND PATHOGENICITY IN DIMORPHIC FUNGI AND USES THEREOF
    Publication number: 20080038201
    Abstract: A method of screening a compound for anti-fungal properties comprising the steps of exposing a test compound to a fungal histidine kinase, and determining whether kinase activity is inhibited, wherein inhibition of kinase activity indicates that the compound has anti-fungal properties is disclosed.
    Type: Application
    Filed: April 12, 2007
    Publication date: February 14, 2008
    Inventors: Bruce Klein, Julie Nemecek, Marcel Wuethrich
  • Attenuated vaccine for Blastomyces dermatitidis
    Patent number: 6248322
    Abstract: Disclosed herein are attenuated forms of the B. dermatitidis fungus. The fungus remains replication competent but is unable to express the WI-1 protein. One can administer this fungus to a dog, human, or other mammal to vaccinate them against the wild type fungus. Preferably, the administration is by subcutaneous injection.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: June 19, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bruce S. Klein, Theodore T. Brandhorst, Marcel Wüthrich