Patents by Inventor Marcelino Bernardo
Marcelino Bernardo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11971302Abstract: A system for measurement of monochromatic attenuation for each wavelength of the spectrum, understood as such the attenuation at a wavelength of the spectrum with the spectral width provided by the measurement equipment, of the spectral attenuation in the spectral range of measurement, understood as such the set of monochromatic attenuations at all the wavelengths throughout the spectral range of measurement, and the total attenuation, understood as such the attenuation calculated by the integration of the spectral attenuation in the spectral range of measurement weighted with the solar spectrum.Type: GrantFiled: July 25, 2019Date of Patent: April 30, 2024Assignee: FUNDACIÓN CENER-CIEMATInventors: Carlos Fernández Peruchena, Ana Bernardos García, Marcelino Sánchez González, Carlos Heras Vila, Iñigo Salina Áriz, Rafael Alonso Esteban
-
Patent number: 9874622Abstract: A system and method for transporting a hyperpolarized substance is disclosed. A transport vessel for transporting such a hyperpolarized substance includes a vessel housing, a chamber formed within the vessel housing that is configured to receive a container holding a hyperpolarized substance, and an electromagnet configured to generate a magnetic containment field about the chamber when a current is supplied thereto, the magnetic containment field comprising a homogeneous magnetic field. The transport vessel also includes a non-magnetic power source to supply the current to the electromagnet and a control circuit configured to selectively interrupt the supply of current to the electromagnet so as to control generation of the magnetic containment field, with the transport vessel being magnetically inert when the supply of current to the electromagnet is interrupted by the control circuit.Type: GrantFiled: September 27, 2013Date of Patent: January 23, 2018Assignee: General Electric CompanyInventors: Timothy William Skloss, Jonathan Alan Murray, Jan Henrik Ardenkjaer-Larsen, Murali K. Cherukuri, Marcelino Bernardo, Nallathamby Devasahayam
-
Patent number: 9358306Abstract: The present disclosure relates to compositions and methods of killing cells. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein, such as a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm?2. The cell is also contacted with one or more therapeutic agents (such as an anti-cancer agent), for example about 0 to 8 hours after irradiating the cell, thereby killing the cell. Also provided are methods of imaging cell killing in real time, using fluorescence lifetime imaging. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.Type: GrantFiled: June 27, 2012Date of Patent: June 7, 2016Assignee: The United States of America, as rep. by the Secretary, Dept. of Health and Human ServicesInventors: Hisataka Kobayashi, Peter Choyke, Marcelino Bernardo
-
Publication number: 20150091573Abstract: A system and method for transporting a hyperpolarized substance is disclosed. A transport vessel for transporting such a hyperpolarized substance includes a vessel housing, a chamber formed within the vessel housing that is configured to receive a container holding a hyperpolarized substance, and an electromagnet configured to generate a magnetic containment field about the chamber when a current is supplied thereto, the magnetic containment field comprising a homogeneous magnetic field. The transport vessel also includes a non-magnetic power source to supply the current to the electromagnet and a control circuit configured to selectively interrupt the supply of current to the electromagnet so as to control generation of the magnetic containment field, with the transport vessel being magnetically inert when the supply of current to the electromagnet is interrupted by the control circuit.Type: ApplicationFiled: September 27, 2013Publication date: April 2, 2015Applicants: General Electric Company, The United States of America, As Represented By The Secretary, Department of Health and Human ServInventors: Timothy William Skloss, Jonathan Alan Murray, Jan Henrik Ardenkjaer-Larsen, Murali K. Cherukuri, Marcelino Bernardo, Nallathamby Devasahayam
-
Publication number: 20140120119Abstract: The present disclosure relates to compositions and methods of killing cells. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein, such as a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm?2. The cell is also contacted with one or more therapeutic agents (such as an anti-cancer agent), for example about 0 to 8 hours after irradiating the cell, thereby killing the cell. Also provided are methods of imaging cell killing in real time, using fluorescence lifetime imaging. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.Type: ApplicationFiled: June 27, 2012Publication date: May 1, 2014Applicant: The United States of America, as rep. by the Secretary, Dept. of Health and Human ServicesInventors: Hisataka Kobayashi, Peter Choyke, Marcelino Bernardo
-
Patent number: 8524239Abstract: The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm?2, thereby killing the cell. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.Type: GrantFiled: July 11, 2011Date of Patent: September 3, 2013Assignee: The United States of America as represented by the Secrectary, Department of Health and Human ServicesInventors: Hisataka Kobayashi, Peter Choyke, Makoto Mitsunaga, Marcelino Bernardo
-
Publication number: 20120010558Abstract: The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm?2, thereby killing the cell. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.Type: ApplicationFiled: July 11, 2011Publication date: January 12, 2012Inventors: Hisataka Kobayashi, Peter Choyke, Makoto Mitsunaga, Marcelino Bernardo