Abstract: Images and quantitative analytical data are displayed in an interactive manner to a user to facilitate efficient and effective diagnosis, treatment, and assessment of an abnormality or pathology. Images acquired over time, which may be acquired with scanners of various modalities, are registered, displayed in a single image, and comparatively quantified to provide historical analysis of a given abnormality or pathology. The historical images and quantitative data may then be analyzed to determine the effectiveness of an applied treatment and provide additional guidance for a to-be implemented treatment. The images may include anatomical images or functional images. The quantitative data may be displayed in an interactive tabular format or displayed graphically through histograms, charts, graphs, and the like.