Patents by Inventor Marcella Marcellini

Marcella Marcellini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorocombretastatin and derivatives thereof
    Patent number: 7572778
    Abstract: The present invention is related to new derivatives of Combretastatin, of Formula obtained by total synthesis. The strategy developed for each of the compounds is to i) replace a halogen (i.e. fluorine atom) to hydrogen on olefinic bound; ii) replace an aromatic ring in a natural product with an amino-aromatic ring. Said compounds recognize and bind the tubulin site: are useful for treating pathological states which arise from or are exacerbated by cell proliferation—as anticancer and/or antiangiogenic activity, in a mammal—to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: August 11, 2009
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Giuseppe Giannini, Domenico Alloatti, Marcella Marcellini, Mauro Marzi, Teresa Riccioni, Maria Ornella Tinti
  • Fluorocombretastatin and derivatives thereof
    Publication number: 20060160778
    Abstract: The present invention is related to new derivatives of Combretastatin, of Formula obtained by total synthesis. The strategy developed for each of the compounds is to i) replace a halogen (i.e. fluorine atom) to hydrogen on olefinic bound; ii) replace an aromatic ring in a natural product with an amino-aromatic ring. Said compounds recognize and bind the tubulin site: are useful for treating pathological states which arise from or are exacerbated by cell proliferation—as anticancer and/or antiangiogenic activity, in a mammal—to pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: July 6, 2004
    Publication date: July 20, 2006
    Inventors: Giuseppe Giannini, Domenico Alloatti, Marcella Marcellini, Mauro Marzi, Teresa Riccioni, Maria Tinti