Patents by Inventor Marcella Yu

Marcella Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-TGF-BETA ANTIBODIES AND THEIR USE
    Publication number: 20250026821
    Abstract: The invention provides an improved pan-TGF-? antibody for treatment of conditions that are mediated by TGF-?, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.
    Type: Application
    Filed: July 9, 2024
    Publication date: January 23, 2025
    Applicant: SANOFI
    Inventors: Gary Shapiro, Kevin Brower, Patrick Finn, Richard C. Gregory, Rao Koduri, Feng Liu, Natalia Malkova, Parminder Mankoo, Jack R. Pollard, Huawei Qiu, Joachim Theilhaber, Christopher Winter, Marcella Yu
  • Methods of Controlling the Formation of Disulfide Bonds in Protein Solutions
    Publication number: 20240392030
    Abstract: Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess. Also disclosed are protein solution parameters that allow for controlling the formation of disulfide bonds. In one example, the methods disclosed herein can be used to control the proportion of half antibody molecules in an antibody solution.
    Type: Application
    Filed: August 1, 2024
    Publication date: November 28, 2024
    Inventors: Kevin P. BROWER, Chris HWANG, Rao KODURI, Konstantin B. KONSTANTINOV, Veena WARIKOO, Jin YIN, Marcella YU
  • Anti-TGF-beta antibodies and their use
    Patent number: 12049496
    Abstract: The invention provides an improved pan-TGF-? antibody for treatment of conditions that are mediated by TGF-?, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: July 30, 2024
    Assignee: Sanofi
    Inventors: Gary Shapiro, Kevin Brower, Patrick Finn, Richard C. Gregory, Rao Koduri, Feng Liu, Natalia Malkova, Parminder Mankoo, Jack R. Pollard, Huawei Qiu, Joachim Theilhaber, Christopher Winter, Marcella Yu
  • CONCENTRATED PERFUSION MEDIUM
    Publication number: 20220340948
    Abstract: The invention relates to a serum-free cell culture perfusion medium comprising the medium components subgrouped into at least three separate aqueous concentrated feeds and a diluent, wherein the resulting serum-free cell culture perfusion medium is pH-adjusting to neutral pH upon mixing. Also provided is a method of preparing said serum-free cell culture perfusion medium. The invention further relates to methods of culturing mammalian cells or producing a protein of interest in perfusion culture using said serum-free cell culture perfusion medium that achieve high productivity at a low cell specific perfusion rate. The invention further relates to the use of the new and improved serum-free cell culture perfusion medium to control osmolality in a perfusion cell culture, wherein increasing osmolality results in an increase in total productivity and/or cell specific productivity by suppressing cell growth during cell culture, e.g., during production phase of perfusion cell culture.
    Type: Application
    Filed: September 25, 2020
    Publication date: October 27, 2022
    Inventors: Jonathan COFFMAN, Henry LIN, Todd LUMAN, Daisie OGAWA, Janani RAVIKRISHNAN, Hayden TESSMAN, Samet YILDIRIM, Marcella YU
  • ANTI-TGF-BETA ANTIBODIES AND THEIR USE
    Publication number: 20220195026
    Abstract: The invention provides an improved pan-TGF-? antibody for treatment of conditions that are mediated by TGF-?, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.
    Type: Application
    Filed: December 23, 2021
    Publication date: June 23, 2022
    Applicant: SANOFI
    Inventors: Gary Shapiro, Kevin Brower, Patrick Finn, Richard C. Gregory, Rao Koduri, Feng Liu, Natalia Malkova, Parminder Mankoo, Jack R. Pollard, Huawei Qiu, Joachim Theilhaber, Christopher Winter, Marcella Yu
  • Anti-TGF-beta antibodies and their use
    Patent number: 11242384
    Abstract: The invention provides an improved pan-TGF-? antibody for treatment of conditions that are mediated by TGF-?, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: February 8, 2022
    Assignee: SANOFI
    Inventors: Gary Shapiro, Kevin Brower, Patrick Finn, Richard C. Gregory, Rao Koduri, Feng Liu, Natalia Malkova, Parminder Mankoo, Jack R. Pollard, Huawei Qiu, Joachim Theilhaber, Christopher Winter, Marcella Yu
  • Methods and Systems for Processing a Cell Culture
    Publication number: 20210269477
    Abstract: Provided herein are methods of processing a cell culture and open circuit filtration systems.
    Type: Application
    Filed: May 14, 2021
    Publication date: September 2, 2021
    Applicant: Genzyme Corporation
    Inventors: Konstantin Konstantinov, Benjamin Wright, Jin Yin, Marcella Yu, Hang Zhou
  • ANTI-TGF-BETA ANTIBODIES AND THEIR USE
    Publication number: 20200399358
    Abstract: The invention provides an improved pan-TGF-? antibody for treatment of conditions that are mediated by TGF-?, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.
    Type: Application
    Filed: July 16, 2020
    Publication date: December 24, 2020
    Inventors: Gary Shapiro, Kevin Brower, Patrick Finn, Richard C. Gregory, Rao Koduri, Feng Liu, Natalia Malkova, Parminder Mankoo, Jack R. Pollard, Huawei Qiu, Joachim Theilhaber, Christopher Winter, Marcella Yu
  • Methods of Controlling the Formation of Disulfide Bonds in Protein Solutions
    Publication number: 20200299402
    Abstract: Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess. Also disclosed are protein solution parameters that allow for controlling the formation of disulfide bonds. In one example, the methods disclosed herein can be used to control the proportion of half antibody molecules in an antibody solution.
    Type: Application
    Filed: April 8, 2020
    Publication date: September 24, 2020
    Inventors: Kevin P. Brower, Chris Hwang, Rao Koduri, Konstantin B. Konstantinov, Veena Warikoo, Jin Yin, Marcella Yu
  • Anti-TGF-? antibodies and their use
    Patent number: 10766955
    Abstract: The invention provides an improved pan-TGF-? antibody for treatment of conditions that are mediated by TGF-?, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: September 8, 2020
    Assignee: SANOFI
    Inventors: Gary Shapiro, Kevin Brower, Patrick Finn, Richard C. Gregory, Rao Koduri, Feng Liu, Natalia Malkova, Parminder Mankoo, Jack R. Pollard, Huawei Qiu, Joachim Theilhaber, Christopher Winter, Marcella Yu
  • Methods of controlling the formation of disulfide bonds in protein solutions
    Patent number: 10647777
    Abstract: Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess. Also disclosed are protein solution parameters that allow for controlling the formation of disulfide bonds. In one example, the methods disclosed herein can be used to control the proportion of half antibody molecules in an antibody solution.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: May 12, 2020
    Assignee: GENZYME CORPORATION
    Inventors: Kevin P. Brower, Chris Hwang, Rao Koduri, Konstantin B. Konstantinov, Veena Warikoo, Marcella Yu, Jin Yin
  • ANTI-TGF-BETA ANTIBODIES AND THEIR USE
    Publication number: 20180244763
    Abstract: The invention provides an improved pan-TGF-? antibody for treatment of conditions that are mediated by TGF-?, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.
    Type: Application
    Filed: January 19, 2018
    Publication date: August 30, 2018
    Applicant: SANOFI
    Inventors: Gary Shapiro, Kevin Brower, Patrick Finn, Richard C. Gregory, Rao Koduri, Feng Liu, Natalia Malkova, Parminder Mankoo, Jack R. Pollard, Huawei Qiu, Joachim Theilhaber, Christopher Winter, Marcella Yu
  • Methods of Controlling the Formation of Disulfide Bonds in Protein Solutions
    Publication number: 20160108127
    Abstract: Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess. Also disclosed are protein solution parameters that allow for controlling the formation of disulfide bonds. In one example, the methods disclosed herein can be used to control the proportion of half antibody molecules in an antibody solution.
    Type: Application
    Filed: March 25, 2015
    Publication date: April 21, 2016
    Inventors: Kevin P. Brower, Chris Hwang, Rao Koduri, Konstantin B. Konstantinov, Veena Warikoo, Jin Yin, Marcella Yu
  • METHODS AND SYSTEMS FOR PROCESSING A CELL CULTURE
    Publication number: 20150158907
    Abstract: Provided herein are methods of processing a cell culture and open circuit filtration systems.
    Type: Application
    Filed: February 20, 2015
    Publication date: June 11, 2015
    Inventors: Hang Zhou, Benjamin Wright, Marcella Yu, Jin Yin, Konstantin Konstantinov
  • CELL CULTURE METHODS TO MAKE ANTIBODIES WITH ENHANCED ADCC FUNCTION
    Publication number: 20110053223
    Abstract: The present invention concerns antibodies with enhanced antibody-dependent cell mediated cytotoxicity (ADCC) and method for preparation thereof.
    Type: Application
    Filed: August 6, 2010
    Publication date: March 3, 2011
    Inventors: Robert Bayer, Feng Li, Efren Pacis, Marcella Yu
  • ANTIBODIES WITH ENHANCED ADCC FUNCTION
    Publication number: 20110003338
    Abstract: The present invention concerns antibodies enhanced antibody-dependent cell mediated cytotoxicity (ADCC) and method for preparation thereof.
    Type: Application
    Filed: March 11, 2009
    Publication date: January 6, 2011
    Inventors: Robert Bayer, Reed J. Harris, Feng Li, Domingos Ng, Efren Pacis, Amy Shen, Marcella Yu