Patents by Inventor Marcelle Van Mechelen

Marcelle Van Mechelen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDES AND METHODS FOR THE TREATMENT OF MULTIPLE SCLEROSIS
    Publication number: 20230340061
    Abstract: The invention relates to immunogenic peptides derived from Myelin Oligodendrocyte Glycoprotein (MOG) for use in the treatment of demyelinating disorders and to the generation of cytolytic CD4+ T cells or NKT cells against antigen presenting cells that present the wild-type MOG epitope sequence.
    Type: Application
    Filed: May 6, 2021
    Publication date: October 26, 2023
    Inventors: Jean-Marie SAINT-REMY, Luc VANDER ELST, Vincent CARLIER, Milos ERAK, Jean VAN RAMPELBERGH, Marcelle VAN MECHELEN, David WALGRAFFE, Geoffrey GLOIRE
  • COMBINATION TREATMENT FOR FUMARATE-RELATED DISEASES
    Publication number: 20230172894
    Abstract: The present invention relates to a pharmaceutical preparation (combination or pharmaceutical composition or kit-of-parts) comprising one or more dose units of a fumarate compound and an immunogenic or tolerogenic peptide comprising an oxidoreductase motif and an NKT cell epitope or an MHC class II T cell epitope of an (auto)antigen involved in fumarate related diseases or disorders. The present invention further relates to medical uses of this pharmaceutical preparation.
    Type: Application
    Filed: May 6, 2021
    Publication date: June 8, 2023
    Inventors: Jean-Marie SAINT-REMY, Luc VANDER ELST, Vincent CARLIER, Milos ERAK, Jean VAN RAMPELBERGH, Marcelle VAN MECHELEN, David WALGRAFFE, Geoffrey GLOIRE, Jean SMAL
  • Epitopes or mimotopes derived from the C-epsilon-3 or C-epsilon-4 domains of IgE, antagonists thereof, and their therapeutic uses
    Publication number: 20050214285
    Abstract: The present invention relates to the provision of novel medicaments for the treatment, prevention or amelioration of allergic disease. In particular, the novel medicaments are isolated peptides incorporating epitopes or mimotopes of surface exposed regions of the C?2 domain of IgE. The inventors have found that these novel regions may be the target for both passive and active immunoprophylaxis or immunotherapy. The invention further relates to methods for production of the medicaments, pharmaceutical compositions containing them and their use in medicine. Also forming an aspect of the present invention are ligands, especially monoclonal antibodies, which are capable of binding the surface exposed IgE regions of the present invention, and their use in medicine as passive immunotherapy or in immunoprophylaxis.
    Type: Application
    Filed: December 7, 2004
    Publication date: September 29, 2005
    Inventors: Michael Dyson, Martin Friede, Judith Greenwood, Ellen Hewitt, Alan Lamont, Sean Mason, Roger Randall, William Turnell, Marcelle Van Mechelen, Carlotta y de Bassols
  • Epitopes or mimotopes derived from the C-epsilon-3 or C-epsilon-4 domains of IgE, antagonists thereof, and their therapeutics uses
    Publication number: 20050152892
    Abstract: The present invention relates to the provision of novel medicaments for the treatment, prevention or amelioration of allergic disease. In particular, the novel medicaments are epitopes or mimotopes derived from the C?3 or C?4 domains of IgE. These novel regions may be the target for both passive and active immunoprophylaxis or immunotherapy. The invention further relates to methods for production of the medicaments, pharmaceutical compositions containing them and their use in medicine. Also forming an aspect of the present invention are ligands, especially monoclonal antibodies, which are capable of binding the IgE regions of the present invention, and their use in medicine as passive immunotherapy or immunoprophylaxis.
    Type: Application
    Filed: December 3, 2004
    Publication date: July 14, 2005
    Inventors: Martin Friede, Sean Mason, William Turnell, Marcelle Van Mechelen, Carlotta de Bassols
  • Method to enhance an immune response of nucleic acid vaccination
    Publication number: 20030072768
    Abstract: This invention provides a method to enhance an immune response of nucleic acid vaccination by simultaneous administration of a polynucleotide and a polypeptide of interest.
    Type: Application
    Filed: November 12, 2002
    Publication date: April 17, 2003
    Applicant: SmithKline Beecham Biologicals, s.a.
    Inventors: Wilfried Dalemans, Marcelle Van Mechelen, Claudine Bruck, Martin Friede
  • Method to enhance an immune response of nucleic acid vaccination
    Patent number: 6500432
    Abstract: This invention provides a method to enhance an immune response of nucleic acid vaccination by simultaneous administration of a polynucleotide and a polypeptide of interest.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: December 31, 2002
    Assignee: SmithKline Beecham Biologicals, S.A.
    Inventors: Wilfried Dalemans, Marcelle Van Mechelen, Claudine Bruck, Martin Friede