Patents by Inventor Marcellino Tibolla

Marcellino Tibolla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidylpyrrole derivatives active as kinase inhibitors
    Patent number: 7279575
    Abstract: Pyrimidylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: August 5, 2004
    Date of Patent: October 9, 2007
    Assignee: Pfizer Italia S.r.l.
    Inventors: Ermes Vanotti, Roberto D'Alessio, Marcellino Tibolla, Mario Varasi, Alessia Montagnoli, Corrado Santocanale, Paolo Orsini, Antonio Pillan
  • Tricyclic pyrazole derivatives, process for their preparation and their use as antitumor agents
    Publication number: 20050176796
    Abstract: Compounds which are tricyclic pyrazole derivatives and analogues thereof, as set forth in the specification, or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
    Type: Application
    Filed: February 18, 2003
    Publication date: August 11, 2005
    Inventors: Roberto D'Alessio, Alberto Bargiotti, Maria Brasca, Antonella Ermoli, Paolo Pevarello, Marcellino Tibolla
  • Pyrimidylpyrrole derivatives active as kinase inhibitors
    Publication number: 20050043323
    Abstract: Pyrimidylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: August 5, 2004
    Publication date: February 24, 2005
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Ermes Vanotti, Roberto D'Alessio, Marcellino Tibolla, Mario Varasi, Alessia Montagnoli, Corrado Santocanale, Paolo Orsini, Antonio Pillan
  • Pyridylpyrrole derivatives active as kinase inhibitors
    Publication number: 20050043346
    Abstract: Pyridylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: August 5, 2004
    Publication date: February 24, 2005
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Ermes Vanotti, Roberto D'Alessio, Marcellino Tibolla, Mario Varasi, Alessia Montagnoli, Corrado Santocanale, Katia Martina, Maria Menichincheri
  • BENZYLOXY PRODIGIOSINE COMPOUNDS
    Publication number: 20020049248
    Abstract: A compound which is a 2-(1H-pyrrol-2-yl)-5[(2H-pyrrol-2-ylidene)methyl]-1H-pyrrole of formula (I), wherein R1 is hydrogen or C1-C5 alkyl; R2 is a C1-C5 alkyl; or a pharmaceutically acceptable salt thereof, is useful as an immunomodulating agent and for treating adult-T-cell leukemia-lymphoma.
    Type: Application
    Filed: October 7, 1999
    Publication date: April 25, 2002
    Inventors: ROBERTO D'ALESSIO, ERMES VANOTTI, ALBERTO BARGIOTTI, MARCELLINO TIBOLLA, MARIO FERRARI, ANNA MARIA ISETTA, FRANCESCO COLOTTA
  • Benzyloxy prodigiosine compounds
    Patent number: 6369096
    Abstract: A compound, having utility as an immunomodulating agent, which is a prodigiosine of formula (I): wherein R1 is hydrogen or C1-C5 alkyl; and R2 is a C1-C5 alkyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: April 9, 2002
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Roberto D'Alessio, Ermes Vanotti, Alberto Bargiotti, Marcellino Tibolla, Mario Ferrari, Anna Maria Isetta, Francesco Colotta
  • Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation
    Patent number: 6071947
    Abstract: The present invention relates to substituted (1H-indol-2-yl)-5[(2H-pyrrol-2-ylidene) methyl]-1H-pyrrole compounds and their use as immunomodulating agents, to the preparation of the compounds and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: June 6, 2000
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Roberto D'Alessio, Marcellino Tibolla, Alberto Bargiotti, Anna Maria Isetta, Mario Ferrari, Francesco Colotta
  • Process for the preparation of 2,2'-bipyrrolyl-pyrromethene (prodigiosins) derivatives
    Patent number: 5847127
    Abstract: The present invention is related to a process for the preparation of 5-?2H-pyrrol-2-ylidene)methyl!-2,2'-bi-1H-pyrrole compounds and an intermediate compound.
    Type: Grant
    Filed: October 15, 1997
    Date of Patent: December 8, 1998
    Assignee: Pharmacia & UpJohn S.p.A.
    Inventors: Roberto D'Alessio, Arsenia Rossi, Marcellino Tibolla, Lucio Ceriani
  • Pyrrolydenemethyl-derivatives and process for their preparation
    Patent number: 5691334
    Abstract: New and known 5-?(2H-pyrrol-2-ylidene)methyl!-2,2'-bi-1H-pyrrole derivatives, having immunomodulating activity and, represented by the general formula (I) and the pharmaceutically acceptable salts thereof, are disclosed.
    Type: Grant
    Filed: August 21, 1995
    Date of Patent: November 25, 1997
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Gianfederico Doria, AnnaMaria Isetta, Marcellino Tibolla, MariaChiara Fornasiero, Mario Ferrari, Domenico Trizio
  • Substituted pyrido [1,2-a] pyrimidines useful as anti-allergic, anti-ulcer and anti-diabetic agents
    Patent number: 4341780
    Abstract: Substituted pyrido [1,2-a] pyrimidines and pharmaceutical compositions containing them, suitable for use as anti-allergy, anti-ulcer, and anti-diabetic agents.
    Type: Grant
    Filed: May 27, 1981
    Date of Patent: July 27, 1982
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Piero Sberze, Marcellino Tibolla, Maria L. Corno
  • 2-(Pyridyl-cyclopropyl)chromones
    Patent number: 4310589
    Abstract: The present invention relates to substituted 2-(pyridyl-cyclopropyl)-chromones, to a process for their preparation and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: September 12, 1980
    Date of Patent: January 12, 1982
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Maria L. Corno, Piero Sberze, Marcellino Tibolla
  • Substituted 6,7-methylene pyrido[1,2-a]pyrimidines useful as anti-allergic and anti-ulcer agents
    Patent number: 4310526
    Abstract: Substituted 6,7-methylen[1,2-a]pyrimidines and pharmaceutical compositions containing them, suitable for use as anti-allergic, anti-ulcer and anti-diabetic agents.
    Type: Grant
    Filed: April 10, 1980
    Date of Patent: January 12, 1982
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Piero Sberze, Marcellino Tibolla, Maria L. Corno
  • Substituted 2-cyclopropyl-chromones and pharmaceutical compositions and use thereof
    Patent number: 4160028
    Abstract: Substituted 2-cyclopropylchromones, process of preparation, pharmaceutical compositions and method of treating allergies are disclosed.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: July 3, 1979
    Assignee: Carlo Erba S.p.A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Maria L. Corno, Francesco Lauria, Piero Sberze, Marcellino Tibolla