Patents by Inventor Marcello Allegretti

Marcello Allegretti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy
    Patent number: 12268671
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of chemotherapy-induced neuropathy, preferably in the treatment and/or prevention of chemotherapy-induced peripheral neuropathy (CIPN) or chemotherapy-induced optic neuropathy.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: April 8, 2025
    Assignee: DOMPÉ FARMACEUTICI S.P.A.
    Inventors: Laura Brandolini, Pier Adelchi Ruffini, Marcello Allegretti
  • IL-8 INIHIBITORS FOR USE IN THE TREATMENT OF SOME UROLOGICAL DISORDERS
    Publication number: 20250032461
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of interstitial cystitis/painful bladder syndrome (IC/PBS) and/or over active bladder (OAB), also including IC/PBS and/or OAB induced by anticancer therapy. Methods of treatment and/or prevention, combinations and kits comprising said IL-8 inhibitors are also covered therein.
    Type: Application
    Filed: October 17, 2024
    Publication date: January 30, 2025
    Inventors: Marcello ALLEGRETTI, Andrea ARAMINI, Maria Candida CESTA, Gianluca BIANCHINI, Laura BRANDOLINI, Patrizia ANGELICO
  • IL-8 INHIBITORS FOR USE IN THE TREATMENT AND/OR PREVENTION OF BACTERIAL SECONDARY INFECTIONS
    Publication number: 20250009719
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of secondary bacterial infections, preferably secondary respiratory infections.
    Type: Application
    Filed: September 23, 2024
    Publication date: January 9, 2025
    Inventors: Laura BRANDOLINI, Marcello Allegretti, Mauro Martins Teixeira
  • Composition containing branched-chain amino acids
    Patent number: 12186359
    Abstract: The present invention relates to compositions comprising branched-chain amino acids (BCAA) and the dipeptide L-Alanyl-L-alanine and their use for improving the performance and recovery during physical activity and for the prevention and/or treatment of muscle wasting associated to pathological or age-related conditions.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: January 7, 2025
    Assignee: DOMPÉ FARMACEUTICI S.P.A.
    Inventors: Marcello Allegretti, Andrea Aramini, Gianluca Bianchini
  • NGF ISOFORM FOR USE IN THE TREATMENT OF OCULAR PATHOLOGIES
    Publication number: 20240424060
    Abstract: The present invention relates to the field of treatment of ocular pathologies by administration of a NGF, which comprises more than 50% by weight of the NGF isoform of SEQ ID NO: 1. Said NGF is particularly useful in the treatment of ocular pathologies where the proliferation and survival effect of NGF is desired and where the proapoptotic effect of p75NTR is detrimental.
    Type: Application
    Filed: July 3, 2024
    Publication date: December 26, 2024
    Inventors: Andrea ARAMINI, Pier Giorgio AMENDOLA, Anna SIRICO, Gaetano D'ANNIBALLE, Franca CATTANI, Marcello ALLEGRETTI, Flavio MANTELLI
  • C5AR INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED IATROGENIC PAIN
    Publication number: 20240398731
    Abstract: The present invention relates to C5aR inhibitor compounds, preferably C5aR noncompetitive allosteric inhibitors, useful in the treatment and/or prevention of chemotherapy-induced iatrogenic pain (CIIP).
    Type: Application
    Filed: August 9, 2024
    Publication date: December 5, 2024
    Inventors: Laura BRANDOLINI, Thiago Mattar CUNHA, Marcello ALLEGRETTI, Andrea ARAMINI, Gianluca BIANCHINI
  • IL-8 inihibitors for use in the treatment of some urological disorders
    Patent number: 12150933
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of interstitial cystitis/painful bladder syndrome (IC/PBS) and/or over active bladder (OAB), also including IC/PBS and/or OAB induced by anticancer therapy. Methods of treatment and/or prevention, combinations and kits comprising said IL-8 inhibitors are also covered therein.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: November 26, 2024
    Assignee: DOMPÈ FARMACEUTICI S.P.A.
    Inventors: Marcello Allegretti, Andrea Aramini, Maria Candida Cesta, Gianluca Bianchini, Laura Brandolini, Patrizia Angelico
  • IL-8 inhibitors for use in the treatment and/or prevention of bacterial secondary infections
    Patent number: 12133843
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of secondary bacterial infections, preferably secondary respiratory infections.
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: November 5, 2024
    Assignee: DOMPÉ FARMACEUTICI S.P.A.
    Inventors: Laura Brandolini, Marcello Allegretti, Mauro Martins Teixeira
  • C5aR inhibitors for use in the treatment of chemotherapy-induced iatrogenic pain
    Patent number: 12102607
    Abstract: The present invention relates to C5aR inhibitor compounds, preferably C5aR noncompetitive allosteric inhibitors, useful in the treatment and/or prevention of chemotherapy-induced iatrogenic pain (CIIP).
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: October 1, 2024
    Assignee: Dompe' Farmaceutici S.P.A.
    Inventors: Laura Brandolini, Thiago Mattar Cunha, Marcello Allegretti, Andrea Aramini, Gianluca Bianchini
  • Prevention and treatment of diabetic nephropathy
    Patent number: 12097172
    Abstract: Embodiments herein disclose methods relating to diabetic nephropathy (DN); methods for preventing the onset and also for preventing the progressing of DN, as well as the treatment of DN in diabetic subjects comprising administering reparixin and/or ladarixin which are inhibitors of CXCL8 receptor CXCR1 and CXCR2 activation.
    Type: Grant
    Filed: February 24, 2022
    Date of Patent: September 24, 2024
    Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION, DOMPE FARMACEUTICI S.P.A.
    Inventors: Paolo Fiorina, Roberto Bassi, Andrea Vergani, Marcello Allegretti
  • C5AR1 INHIBITORS FOR TREATING HYPERSENSITIVITY REACTIONS TO TAXANES
    Publication number: 20240180888
    Abstract: The present invention relates to the use of a C5aR1 inhibitor for the prevention or treatment of a hypersensitivity reaction (HSR) to a taxane in an individual.
    Type: Application
    Filed: March 17, 2022
    Publication date: June 6, 2024
    Inventors: Marcello ALLEGRETTI, Andrea ARAMINI, Piergiorgio AMENDOLA, Laura BRANDOLINI, Maria Candida CESTA, Anna SIRICO
  • COMBINATION THERAPY FOR COVID-19 VACCINATION
    Publication number: 20240180889
    Abstract: The present invention relates to the combination of a Selective Estrogen Receptor Modulator (SERM) and a COVID-19 vaccine.
    Type: Application
    Filed: March 31, 2022
    Publication date: June 6, 2024
    Inventors: Marcello ALLEGRETTI, Andrea Rosario BECCARI, Maria Candida CESTA, Elisabetta Maria Ester MAURI, Carmine TALARICO
  • CXCL8 INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF FOR USE IN THE TREATMENT OF SEIZURES
    Publication number: 20240156757
    Abstract: The present invention relates to a CXCL8 inhibitor and a pharmaceutical composition thereof, for use in the prevention or treatment of seizures.
    Type: Application
    Filed: March 3, 2022
    Publication date: May 16, 2024
    Inventors: Marcello ALLEGRETTI, Laura BRANDOLINI, Annamaria VEZZANI, Rossella DI SAPIA, Teresa RAVIZZA, Silvia Maria BALOSSO
  • NGF ISOFORM FOR USE IN THE TREATMENT OF OCULAR PATHOLOGIES
    Publication number: 20240091311
    Abstract: The present invention relates to the field of treatment of ocular pathologies by administration of a NGF, which comprises more than 50% by weight of the NGF isoform of SEQ ID NO: 1. Said NGF is particularly useful in the treatment of ocular pathologies where the proliferation and survival effect of NGF is desired and where the proapoptotic effect of p75NTR is detrimental.
    Type: Application
    Filed: February 4, 2022
    Publication date: March 21, 2024
    Inventors: Andrea ARAMINI, Pier Giorgio AMENDOLA, Anna SIRICO, Gaetano D'ANNIBALLE, Franca CATTANI, Marcello ALLEGRETTI, Flavio MANTELLI
  • PHARMACEUTICAL PACKAGES COMPRISING POLYPROPYLENE CONTAINERS AND NGF AQUEOUS FORMULATIONS PACKAGED THEREIN
    Publication number: 20230390156
    Abstract: The present invention relates to a pharmaceutical package comprising a plastic container and an aqueous formulations of nerve growth factor (NGF), in which at least the surface of the container in contact with the NGF aqueous formulation is made of particular polypropylenes (PPs), characterized by certain thermal properties and crystallinity. Advantageously said containers show a NGF adhesion significantly lower than that of siliconized glass or of other polypropylenes. It is thus possible to store aqueous formulations of NGF in less severe conditions, avoiding additional coating treatments to the containers and additives while keeping the NGF titer constant.
    Type: Application
    Filed: October 27, 2021
    Publication date: December 7, 2023
    Inventors: Marcello ALLEGRETTI, Lucia APPARENTE, Marco Maria GENTILE, Simone MATTIOLI
  • CO-CRYSTAL OF KETOPROFEN, LYSINE AND GABAPENTIN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE
    Publication number: 20230357121
    Abstract: The present invention relates to a new co-crystal of Ketoprofen, Lysine and Gabapentin, to pharmaceutical compositions and to their use in the prevention, reduction or treatment of pain and/or inflammation.
    Type: Application
    Filed: May 4, 2021
    Publication date: November 9, 2023
    Inventors: Andrea ARAMINI, Marcello ALLEGRETTI, Gianluca BIANCHINI, Samuele LILLINI, Mara TOMASSETTI
  • CO-CRYSTAL OF GABAPENTIN, KETOPROFEN AND LYSINE, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE
    Publication number: 20230181507
    Abstract: The present invention relates to a new co-crystal of Gabapentin, Ketoprofen and Lysine, to pharmaceutical compositions and to their use in the prevention, reduction or treatment of pain and/or inflammation.
    Type: Application
    Filed: April 21, 2021
    Publication date: June 15, 2023
    Inventors: Andrea ARAMINI, Marcello ALLEGRETTI, Gianluca BIANCHINI, Samuele LILLINI, Mara TOMASSETTI
  • SYNERGISTIC ADMIXTURES OF GABAPENTIN AND KETOPROFEN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE
    Publication number: 20230165820
    Abstract: The present invention relates to a synergistic admixture of Gabapentin and Ketoprofen, preferably Ketoprofen Lysine, to a pharmaceutical composition comprising said admixtures and to the use of said admixtures or pharmaceutical compositions in the treatment of acute or chronic pain, in particular in the treatment of neuropathic or inflammatory pain.
    Type: Application
    Filed: April 21, 2021
    Publication date: June 1, 2023
    Inventors: Andrea ARAMINI, Marcello ALLEGRETTI, Gianluca BIANCHINI, Samuele LILLINI, Mara TOMASSETTI, Laura BRANDOLINI
  • CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF COVID-19
    Publication number: 20230141355
    Abstract: The present invention relates to CXCL8 inhibitors for use in the treatment of COVID-19 patients with pneumonia.
    Type: Application
    Filed: March 24, 2021
    Publication date: May 11, 2023
    Inventors: Marcello ALLEGRETTI, Flavio MANTELLI, Lorenzo PIEMONTI
  • CXCL8 (INTERLEUKIN-8) ACTIVITY INHIBITOR AND CORTICOSTEROID COMBINATION AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Publication number: 20230108050
    Abstract: The present invention relates to a combination of a CXCL8 activity inhibitor and a corticosteroid, and a pharmaceutical composition thereof, for use in the treatment of corticosteroid-insensitive asthma as well as to a method for treating corticosteroid-insensitive asthma by administration of said pharmaceutical composition.
    Type: Application
    Filed: February 18, 2021
    Publication date: April 6, 2023
    Inventors: Remo De Castro RUSSO, Mauro Martins TEIXEIRA, Marcello ALLEGRETTI, Laura BRANDOLINI