Patents by Inventor Marcelo B. Sztein

Marcelo B. Sztein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using Zot to inhibit lymphocyte proliferation in an antigen-specific manner
    Patent number: 6733762
    Abstract: Methods of using Zot or zonulin as an antigen specific inhibitor of APC activity and lymphocyte proliferation, being primarily useful in the field of immunoregulation and immunotherapy as described. Specifically, Zot and zonulin inhibit antigen presenting cell-mediated antigen-specific lymphocyte proliferation in a dose dependent manner. This effect is associated with the presence of a macrophage surface receptor to which Zot binds in a specific and saturable way. This down-regulation of the immune response is, at least in part, associated with a decreased uptake of antigen.
    Type: Grant
    Filed: May 3, 2001
    Date of Patent: May 11, 2004
    Assignee: University of Maryland, Baltimore
    Inventors: Alessio Fasano, Marcelo B. Sztein, Ruiliang Lu, Michael K. Tanner
  • Attenuated mutants of salmonella which constitutively express the Vi antigen
    Patent number: 6190669
    Abstract: Attenuated Salmonella mutants which constitutively express the Vi antigen are disclosed, as well as vaccines against typhoid fever containing the same, live vector vaccines containing the same, and DNA-mediated vaccines containing the same.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: February 20, 2001
    Assignee: University of Maryland, Baltimore
    Inventors: Fernando R. Noriega, Marcelo B. Sztein, Myron M. Levine