Abstract: Multi-sense point voltage regulator systems are provided for usage in conjunction with power-regulated devices, such as system-on-chip and microcontroller unit devices. In embodiments, the multi-sense point voltage regulator system includes a multiplexer selector circuit and a voltage regulator. The multiplexer selector circuit is configured to: (i) monitor a local voltages at multiple sense points within an integrated circuit (IC) die circuit structure; and (ii) generate a feedback voltage indicative of a lowest one of the monitored local voltages. The voltage regulator is configured to generate a regulated power supply output voltage as a function of a differential between the feedback voltage and the reference voltage, with the regulated power supply output voltage provided to the IC die circuit structure to drive operation thereof.