Abstract: The present invention relates to methods for diagnosing, monitoring or prognosticating prostate cancer or the progression state of prostate cancer wherein said method determines the state of the prostate cancer, based on the expression level of phosphodiesterase 4D (PDE4D) variants. The invention further relates to a method of identifying an individual for eligibility for prostate cancer therapy. The invention also relates to products for the analysis of phosphodiesterase 4D (PDE4D) variants as well as pharmaceutical compositions modulating the activity and/or expression of PDE4D variants.

Abstract: A method for estimating heterogeneity of a tumour based on values for two or more genome mutation and/or gene expression related parameters for at least two spatially differentiated areas in a sample, the sample being a tissue sample of a tumour or a liquid sample obtained from a subject having the tumour, the method comprising the steps of determining a sample heterogeneity score for the heterogeneity of the sample based on variabilities of each measured value for the at least two spatially differentiated areas, estimating the heterogeneity of the tumour by extrapolating the score for the heterogeneity of the sample to the tumour, thereby providing a tumour heterogeneity score.

Abstract: The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.

Abstract: The present invention relates to a computer-implemented method for inferring activity of a PR cellular signaling pathway in a subject based on expression levels of three or more target genes of the PR cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a PR cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the PR cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a PR cellular signaling pathway in a subject, and to the use of such kits in performing the method.

Abstract: The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.

Abstract: A rotational position determination apparatus is configured to determine an entry rotational position, which defines a rotational position of an insertion device like a stent at an entry site, such that a navigation of the insertion device from the entry site to a target site along an inner path results in a rotational position of the insertion device at the target site being equal to a desired target rotational position based on a representation of the inner path and the desired target rotational position. If the insertion device is arranged in the determined entry rotational position at the entry site and then navigated to the target site, it is therefore not necessary to rotate the insertion device at the target site.

Abstract: A method for determining a risk score that indicates a risk that a clinical event will occur within a certain period of time. The risk score is based at least in part on a combination of inferred activities of two or more cellular signaling pathways in a tissue and/or cells and/or a body fluid of a subject. The cellular signaling pathways comprise a Wnt pathway, an ER pathway, an HH pathway, and/or an AR pathway. The risk score is defined such that the indicated risk that the clinical event will occur within the certain period of time decreases with an increasing PER and increases with an increasing max(PWnt, PHH), wherein PER, PWnt, and PHH denote the inferred activity of the ER pathway, the Wnt pathway, and the HH pathway, respectively.

Abstract: Methods are described for stratifying patient risk for patients with prostate cancer and for providing a treatment recommendation to a patient based on a phosphodiesterase 4D variant 7 (PDE4D7) risk score. A diagnostic kit and a computer program product for the analysis and determination of the PDE4D7 risk score are also described.

Abstract: Methods are described for stratifying patient risk for patients with prostate cancer and for providing a treatment recommendation to a patient based on a phosphodiesterase 4D variant 7 (PDE4D7) risk score. A diagnostic kit and a computer program product for the analysis and determination of the PDE4D7 risk score are also described.

Abstract: The present invention relates to systems for planning use of resources under consideration of time constraints. The present invention further relates to methods for scheduling use of resources under consideration of time constraints.

Abstract: A rotational position determination apparatus is configured to determine an entry rotational position, which defines a rotational position of an insertion device like a stent at an entry site, such that a navigation of the insertion device from the entry site to a target site along an inner path results in a rotational position of the insertion device at the target site being equal to a desired target rotational position based on a representation of the inner path and the desired target rotational position. If the insertion device is arranged in the determined entry rotational position at the entry site and then navigated to the target site, it is therefore not necessary to rotate the insertion device at the target site.

Abstract: A rotational position determination apparatus is configured to determine an entry rotational position, which defines a rotational position of an insertion device like a stent at an entry site, such that a navigation of the insertion device from the entry site to a target site along an inner path results in a rotational position of the insertion device at the target site being equal to a desired target rotational position based on a representation of the inner path and the desired target rotational position. If the insertion device is arranged in the determined entry rotational position at the entry site and then navigated to the target site, it is therefore not necessary to rotate the insertion device at the target site.

Abstract: The present invention pertains to methods for determining gene expression signatures for diagnosing patients with prostate cancer, e.g., to establish a prognosis for such patients, for determining the predisposition of said patient to develop aggressive or indolent disease, for example after primary treatment, and/or for identification and stratification of patients for available therapies. The invention also relates to products used in such methods, e.g. kits, software, and the like. The present invention further relates to therapies for use in the treatment of patients that have been diagnosed, identified, or stratified in any of the methods dis closed herein.

Abstract: The present invention relates to methods for diagnosing, monitoring or prognosticating prostate cancer or the progression state of prostate cancer wherein said method determines the state of the prostate cancer, based on the expression level of phosphodiesterase 4D (PDE4D) variants. The invention further relates to a method of identifying an individual for eligibility for prostate cancer therapy. The invention also relates to products for the analysis of phosphodiesterase 4D (PDE4D) variants as well as pharmaceutical compositions modulating the activity and/or expression of PDE4D variants.

Abstract: Methods are described for stratifying patient risk for patients with prostate cancer and for providing a treatment recommendation to a patient based on a phosphodiesterase 4D variant 7 (PDE4D7) risk score. A diagnostic kit and a computer program product for the analysis and determination of the PDE4D7 risk score are also described.

Abstract: The present application relates to a method for determining a risk score that indicates a risk that a clinical event will occur within a certain period of time. The risk score is based at least in part on a combination of inferred activities of two or more cellular signaling pathways in a tissue and/or cells and/or a body fluid of a subject. The cellular signaling pathways comprise a Wnt pathway, an ER pathway, an HH pathway, and/or an AR pathway. The risk score is defined such that the indicated risk that the clinical event will occur within the certain period of time decreases with an increasing PER and increases with an increasing max(PWnt, PHH), wherein PER, Pwnt, and PHH denote the inferred activity of the ER pathway, the Wnt pathway, and the HH pathway, respectively.

Abstract: The present invention relates to systems for planning use of resources under consideration of time constraints. The present invention further relates to methods for scheduling use of resources under consideration of time constraints.

Abstract: A medical system (10) which presents consumer health results includes a consumer questionnaire unit (14), a workflow assistant (20), a risk assessor (26), a guideline interpreter (28), and a display device (36). The consumer questionnaire unit (14) identifies consumer habits based on received responses to personal, medical, and lifestyle questions. The workflow assistant (20) iteratively identifies medical tests for the consumer based on a rule based evaluation of responses and received medical test results. The risk assessor (26) calculates a health risk to the consumer based on the identified habits and lifestyle behaviors and received medical test results, and determines body damage to the consumer based on received medical test results. The guideline interpreter (28) constructs a lifestyle advice display based on the identified consumer habits, the calculated health risk, the determined body damage, and lifestyle advice. The display device (36) displays the lifestyle advice display.

Abstract: The invention relates to a rotational position determination apparatus (15) for determining an entry rotational position, which defines a rotational position of an insertion device like a stent at an entry site (5), such that a navigation of the insertion device from the entry site to a target site (6) along an inner path (8) results in a rotational position of the insertion device at the target site being equal to a desired target rotational position based on a representation of the inner path and the desired target rotational position. If the insertion device is arranged in the determined entry rotational position at the entry site and then navigated to the target site, it is therefore not necessary to rotate the insertion device at the target site, i.e. it is not necessary to use a technically complex interventional device for rotating the insertion device at the target site.

Abstract: The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.