Patents by Inventor Marcia S. Osburne

Marcia S. Osburne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacillus subtilis siderophore genes
    Patent number: 5554507
    Abstract: An isolated nucleic acid sequence is described having at least one siderophore biosynthetic gene from Bacillus subtilis encoding enzymes homologous to enterobactin enzymes EntA, EntB, EntC, EntE, and combinations thereof. Vectors containing the isolated nucleic acid sequence, host cells transformed wth the isolated nucleic acid sequence, and a method for identifying compounds having antibiotic activity against microorganisms with an enterobactin-type siderophore are also described.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: September 10, 1996
    Assignee: American Cyanamid Company
    Inventors: Trudy H. Grossman, Marcia S. Osburne
  • Assay for detection of bacterial iron transport inhibitors
    Patent number: 5338664
    Abstract: The present invention relates to a method for identifying a TonB inhibitor in a test sample comprising:(a) growing a TonB.sup.+ microorganism in the presence of the test sample and a lethal agent, the activity of which is mediated by TonB;(b) identifying as positive a test sample with which the lethal activity of the agent is not observed;(c) growing on a low-iron medium a TonB.sup.+ microorganism in the presence of the test sample identified as positive in (b);(d) confirming as positive a test sample with which growth inhibition of the microorganism is observed on a low-iron medium.
    Type: Grant
    Filed: December 4, 1992
    Date of Patent: August 16, 1994
    Assignee: American Cyanamid Company
    Inventors: Margareta K. Tuckman, Marcia S. Osburne