Patents by Inventor Marcia W. Patchan

Marcia W. Patchan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Determination of metal ions in solution by photoluminescence anisotropy
    Patent number: 6284544
    Abstract: Homogeneous fluorescence polarization (anisotropy) assays for detecting and quantifying metal ions in solution, based the metal-dependent binding of a fluorescent ligand to an unlabeled macromolecule, or the binding of a metal ion to a fluorescent labeled macromolecule. The metal-dependent binding of a fluorescent ligand to an unlabeled macromolecule (metallo-macromolecule) effects a measurable change in anisotropy as will the binding of metal ions to a fluorescent labeled macromolecule. Binding of the fluorescent ligand to the unlabeled macromolecule is metal dependent with the change in anisotropy being proportional to the concentration of bound metal ions. No binding of the fluorescent ligand to the macromolecule occurs in the absence of metal ions. Conversely, if the fluorescent label is first conjugated to a metallo-macromolecule and the metallo-macromolecule is subsequently stripped of its metal ion, it may then be used to transduce the binding of metal ions.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: September 4, 2001
    Assignees: University of Pennsylvania, University of Maryland
    Inventors: Richard B. Thompson, Daniel Elbaum, Vincent L. Feliccia, David Christianson, Marcia W. Patchan, Zhengfang Ge, Badri P. Maliwal
  • Enzyme-based fluorescence biosensor for chemical analysis
    Patent number: 6225127
    Abstract: This invention generally relates to the detection, determination, and quantitation of certain ions and small molecules involving the quenching of a fluorescent label attached to a macromolecule, often due to fluorescence energy transfer to a colored inhibitor or certain metal ions bound to the macromolecule.
    Type: Grant
    Filed: March 15, 1999
    Date of Patent: May 1, 2001
    Assignee: University of Maryland, Baltimore
    Inventors: Richard B. Thompson, Marcia W. Patchan, Zhenfang Ge
  • Enzyme-based fluorescence biosensor for chemical analysis
    Patent number: 5952236
    Abstract: This invention generally relates to the detection, determination, and quantitation of certain ions and small molecules involving the quenching of a fluorescent label attached to a macromolecule, often due to fluorescence energy transfer to a colored inhibitor or certain metal ions bound to the macromolecule.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: September 14, 1999
    Inventors: Richard B. Thompson, Marcia W. Patchan, Zhengfang Ge