Patents by Inventor Marcian Van Dort

Marcian Van Dort has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of MEK/PI3K, JAK/MEK, JAK/PI3K/mTOR and MEK/PI3K/mTOR biological pathways and methods for improving lymphatic uptake, bioavailability, and solubility of therapeutic compounds
    Patent number: 11311624
    Abstract: Inhibitors of mTOR, MEK, JAK and PI3K and compositions containing the same are disclosed. Methods of using the inhibitors in the treatment of a variety of diseases and conditions wherein inhibition of one or more of mTOR, MEK, JAK and PI3K provides a benefit also are disclosed. Methods of using chemical attachment moieties and linkers for the purposes of modifying compound solubility and/or lymphatic absorption are also disclosed.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: April 26, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Brian D. Ross, Marcian Van Dort
  • Multifunctional inhibitors of MEK/PI3K and mTOR/MEK/PI3K biological pathways and therapeutic methods using the same
    Patent number: 10919877
    Abstract: Multifunctional inhibitors of mTOR, MEK, and PI3K and compositions containing the same are disclosed. Methods of using the multifunctional inhibitors in the treatment of diseases and conditions wherein inhibition of one or more of mTOR, MEK, and PI3K provides a benefit, like cancers, also are disclosed.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: February 16, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Brian D. Ross, Marcian Van Dort
  • INHIBITORS OF MEK/PI3K, JAK/MEK, JAK/PI3K/mTOR AND MEK/PI3K/mTOR BIOLOGICAL PATHWAYS AND METHODS FOR IMPROVING LYMPHATIC UPTAKE, BIOAVAILABILITY, AND SOLUBILITY OF THERAPEUTIC COMPOUNDS
    Publication number: 20200164081
    Abstract: Inhibitors of mTOR, MEK, JAK and PI3K and compositions containing the same are disclosed. Methods of using the inhibitors in the treatment of a variety of diseases and conditions wherein inhibition of one or more of mTOR, MEK, JAK and PI3K provides a benefit also are disclosed. Methods of using chemical attachment moieties and linkers for the purposes of modifying compound solubility and/or lymphatic absorption are also disclosed.
    Type: Application
    Filed: August 8, 2018
    Publication date: May 28, 2020
    Inventors: Brian D. Ross, Marcian Van Dort
  • MULTIFUNCTIONAL INHIBITORS OF MEK/PI3K AND mTOR/MEK/PI3K BIOLOGICAL PATHWAYS AND THERAPEUTIC METHODS USING THE SAME
    Publication number: 20190224207
    Abstract: Multifunctional inhibitors of mTOR, MEK, and PI3K and compositions containing the same are disclosed. Methods of using the multifunctional inhibitors in the treatment of diseases and conditions wherein inhibition of one or more of mTOR, MEK, and PI3K provides a benefit, like cancers, also are disclosed.
    Type: Application
    Filed: July 6, 2017
    Publication date: July 25, 2019
    Inventors: Brian D. Ross, Marcian Van Dort
  • Dual MEK/PI3K inhibitors and therapeutic methods using the same
    Patent number: 9611258
    Abstract: Dual inhibitors of MEK and PI3K and compositions containing the same are disclosed. Methods of using the dual MEK/PI3K inhibitors in the treatment of diseases and conditions wherein inhibition of MEK and PI3K provides a benefit, like cancers, also are disclosed.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: April 4, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Brian D. Ross, Marcian Van Dort, Christopher Whitehead
  • DUAL MEK/PI3K INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
    Publication number: 20160002212
    Abstract: Dual inhibitors of MEK and PI3K and compositions containing the same are disclosed. Methods of using the dual MEK/PI3K inhibitors in the treatment of diseases and conditions wherein inhibition of MEK and PI3K provides a benefit, like cancers, also are disclosed.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 7, 2016
    Inventors: Brian D. Ross, Marcian Van Dort, Christopher Whitehead
  • Iodinated clonidine derivatives as radioactive imaging tracers
    Patent number: 4883649
    Abstract: Iodinated clonidine derivatives useful, inter alia, as a probe for identification and characterization of .alpha..sub.2 -adrenergic receptor sites and as tracers for imaging techniques such as positron emission tomography or computer assisted tomography. Binding competition studies have indicated that p-iodoclonidine, for example, is a particularly efficacious binder for .alpha..sub.2 -adrenergic sites.
    Type: Grant
    Filed: October 13, 1988
    Date of Patent: November 28, 1989
    Assignee: The University of Michigan
    Inventors: Raymond E. Counsell, Marcian Van Dort, Richard Neubig