Patents by Inventor Marcin Tomasz Kortylewski

Marcin Tomasz Kortylewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CTLA-4 aptamer siRNA species
    Patent number: 10711272
    Abstract: Provided herein are, inter alia, nucleic acid compounds useful for targeting CTLA-4-expressing cells and modulating cell activity of the CTLA-4-expressing cells. The compositions provided herein may be part of pharmaceutical compositions and may be used for treatment of cancer, inflammatory diseases, infectious diseases or metabolic diseases.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: July 14, 2020
    Assignee: City of Hope
    Inventors: Hua Yu, Andreas Herrmann, Marcin Tomasz Kortylewski
  • STAT3 INHIBITORS AND USES THEREOF
    Publication number: 20180312843
    Abstract: Described herein, inter alia, are STAT-binding nucleic acids-including compositions and methods of using the same.
    Type: Application
    Filed: May 18, 2018
    Publication date: November 1, 2018
    Inventors: Marcin Tomasz Kortylewski, Piotr Marek Swiderski
  • COMPOUNDS AND COMPOSITIONS INCLUDING PHOSPHOROTHIOATED OLIGODEOXYNUCLEOTIDE, AND METHODS OF USE THEREOF
    Publication number: 20180312837
    Abstract: The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a modified anti-microRNA sequence, compositions of such a compound, and method of treatment of a disease, and method of suppressing microRNA activity by the disclosed compound or composition.
    Type: Application
    Filed: October 14, 2016
    Publication date: November 1, 2018
    Inventors: Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Guido Marcucci, Bin Zhang, Ya-Huei Kuo
  • COMPOUNDS AND COMPOSITIONS INCLUDING PHOSPHOROTHIOATED OLIGODEOXYNUCLEOTIDE, AND METHODS OF USE THEREOF
    Publication number: 20180185497
    Abstract: The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short-activating RNA (saRNA) or an antisense oligonucleotide sequence (ASO), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating immune response), method of immune stimulation, method of activating CEBPA, and method of reducing activity of STAT transcription factor, by one of the disclosed compounds or compositions.
    Type: Application
    Filed: June 30, 2016
    Publication date: July 5, 2018
    Applicant: City of Hope
    Inventors: Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Dayson Friaca Moreira
  • STAT3 inhibitors and uses thereof
    Patent number: 9976147
    Abstract: Described herein, inter alia, are STAT-binding nucleic acids-including compositions and methods of using the same.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: May 22, 2018
    Assignee: City of Hope
    Inventors: Marcin Tomasz Kortylewski, Piotr Marek Swiderski
  • STAT3 INHIBITORS AND USES THEREOF
    Publication number: 20160333350
    Abstract: Described herein, inter alia, are STAT-binding nucleic acids-including compositions and methods of using the same.
    Type: Application
    Filed: May 20, 2016
    Publication date: November 17, 2016
    Inventors: Marcin Tomasz Kortylewski, Piotr Marek Swiderski
  • CTLA-4 APTAMER SIRNA SPECIES
    Publication number: 20150203848
    Abstract: Provided herein are, inter alia, nucleic acid compounds useful for targeting CTLA-4-expressing cells and modulating cell activity of the CTLA-4-expressing cells. The compositions provided herein may be part of pharmaceutical compositions and may be used for treatment of cancer, inflammatory diseases, infectious diseases or metabolic diseases.
    Type: Application
    Filed: January 21, 2015
    Publication date: July 23, 2015
    Inventors: Hua Yu, Andreas Herrmann, Marcin Tomasz Kortylewski