Patents by Inventor Marcio Voloch

Marcio Voloch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for purifying adenoviruses
    Patent number: 7393631
    Abstract: Methods for purifying adenoviruses from a contaminated sample using a hydroxyapatite medium are provided. Sodium chloride concentrations present in buffers used throughout the method are at least 150 mM to prevent the adenovirus from irreversibly binding to the hydroxyapatite. Levels of contaminants and empty adenovirus capsids from samples purified by conventional purification techniques are further reduced to provide a highly pure adenovirus preparation.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: July 1, 2008
    Assignee: Schering Corporation
    Inventors: Susan V. Cannon-Carlson, Collette Cutler, Gary J. Vellekamp, Marcio Voloch
  • Method for purifying adenoviruses
    Publication number: 20060105456
    Abstract: Methods for purifying adenoviruses from a contaminated sample using a hydroxyapatite medium are provided. Sodium chloride concentrations present in buffers used throughout the method are at least 150 mM to prevent the adenovirus from irreversibly binding to the hydroxyapatite. Levels of contaminants and empty adenovirus capsids from samples purified by conventional purification techniques are further reduced to provide a highly pure adenovirus preparation.
    Type: Application
    Filed: January 5, 2006
    Publication date: May 18, 2006
    Inventors: Susan Cannon-Carlson, Collette Cutler, Gary Vellekamp, Marcio Voloch
  • Methods for producing cell lines stable in serum-free medium suspension culture
    Publication number: 20050153419
    Abstract: The present invention provides methods for adapting cells, such as A549 cells, to growth in serum-free and animal material-free medium suspension culture. The present invention provides methods for preparing viruses, such as adenovirus, from the A549 cells adapted for growth in serum-free and animal material-free medium in suspension culture.
    Type: Application
    Filed: December 21, 2004
    Publication date: July 14, 2005
    Inventors: Zhong Liu, Robert Longley, Marc Santoro, Marcio Voloch
  • Method for purifying adenoviruses
    Publication number: 20020064860
    Abstract: Methods for purifying adenoviruses from a contaminated sample using a hydroxyapatite medium are provided. Sodium chloride concentrations present in buffers used throughout the method are at least 150 mM to prevent the adenovirus from irreversibly binding to the hydroxyapatite. Levels of contaminants and empty adenovirus capsids from samples purified by conventional purification techniques are further reduced to provide a highly pure adenovirus preparation.
    Type: Application
    Filed: November 16, 2001
    Publication date: May 30, 2002
    Applicant: Schering Corporation
    Inventors: Susan V. Cannon-Carlson, Collette Cutler, Gary J. Vellekamp, Marcio Voloch
  • Methods for conversion of protein isoforms
    Patent number: 6281337
    Abstract: The present invention provides methods for isolating adjunct isoforms of proteins and converting them to the desired protein. In preferred embodiments, the present invention contemplates the use of acid solutions or zinc solutions to cleave a chemical group from a desired protein. In further preferred embodiments, the present invention contemplates the oxidation of reduced sulfhydryl groups with cleavage of chemical groups to form a functional desired protein.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: August 28, 2001
    Assignee: Schering Corporation
    Inventors: Susan Cannon-Carlson, Andres Frei, Seoju Lee, Roland Mengisen, Marcio Voloch, David C. Wylie