Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: A controllable optical lens system, comprises a chamber housing first and second fluids, the interface between the fluids defining a lens surface. An electrode arrangement controls the shape of the lens surface and has first and second electrodes. A parameter is determined by the system dependent on the electrical resistance through at least one of the lens fluids between the first and second electrodes. Thus, the series resistance through a lens fluid is used as a measure of meniscus position.

Abstract: A controllable optical lens system, comprises a chamber housing first and second fluids, the interface between the fluids defining a lens surface. An electrode arrangement controls the shape of the lens surface and has first and second electrodes. A parameter is determined by the system dependent on the electrical resistance through at least one of the lens fluids between the first and second electrodes. Thus, the series resistance through a lens fluid is used as a measure of meniscus position.

Abstract: A controllable optical lens comprises a chamber housing first and second fluids, the interface between the fluids defining a lens surface. An electrode arrangement controls the shape of the lens surface and is also for sensing the shape of the lens surface. The electrode arrangement comprising a plurality of electrode segments at different angular orientations about an optical axis of the lens. Surface characteristics are sensed at a plurality of angular orientations from the plurality of electrode segments, and in this way the local shape characteristics of the lens at different angular positions around the lens can be determined. In this way, asymmetry can be detected.

Abstract: A controllable optical lens system, comprises a chamber housing first and second fluids, the interface between the fluids defining a lens surface. An electrode arrangement controls the shape of the lens surface and has first and second electrodes. A parameter is determined by the system dependent on the electrical resistance through at least one of the lens fluids between the first and second electrodes. Thus, the series resistance through a lens fluid is used as a measure of meniscus position.

Abstract: The present invention discloses an optical device comprising a container enclosing an insulating liquid (A) and an electrically susceptible liquid (B), the insulating liquid (A) and the electrically susceptible liquid (B) being immiscible and being in contact with each other via an interface (14), at least one of the liquids (A; B) being at least partially placed in a light path through the container. The optical device further comprises heating means (2, 12, 20) that preferably are responsive to a temperature sensor (30) for heating the insulating liquid (A) and the electrically susceptible liquid (B). Consequently, an optical device is obtained in which the influence of the temperature dependence of the physical properties of the insulating liquid (A) and the electrically susceptible liquid (B) on the behavior of the optical device is reduced, thus yielding an optical device with improved optical characteristics at low temperatures.