Abstract: The present invention consists of a platform to obtain monoclonal antibodies that bind with high affinity processed tumor-specific forms of proteins. The platform is characterized by immunization methods that use as immunogenic material the processed target protein and domains thereof, expressed endogenously or in heterologous systems making use of various host cells, and screening methods that identify the antibodies that recognise and bind specifically and differentially the processed tumor-specific protein versus the same protein as expressed by normal tissues. As an example, the use of the platform is described to obtain specific antibodies for the processed tumor-specific form of Trop-2. The platform can be used to obtain targeted anticancer pharmaceutical products with an improved therapeutic index thanks to the reduction of on-target toxicity against normal tissues. The platform can also be used to obtain reagents for use in the diagnosis, prognosis and monitoring of tumors and metastases.

Abstract: An apparatus is provided for shearing a metallic belt from which electrodes of electric accumulators are formed. The apparatus includes a cutting device able to shear a metallic belt advancing along a sliding path, a first slider positioned upstream of the cutting device and a second slider positioned downstream of the cutting device. A handling system drives the first slider and the second slider cyclically with corresponding outward and return strokes, in order to change the length of the sliding path in such a way as to stop cyclically successive portions of the metallic belt at the cutting device, maintaining constant the advancement velocity of the metallic belt upstream and downstream of the cutting device.

Abstract: An apparatus is provided for shearing a metallic belt from which electrodes of electric accumulators are formed. The apparatus includes a cutting device able to shear a metallic belt advancing along a sliding path, a first slider positioned upstream of the cutting device and a second slider positioned downstream of the cutting device. A handling system drives the first slider and the second slider cyclically with corresponding outward and return strokes, in order to change the length of the sliding path in such a way as to stop cyclically successive portions of the metallic belt at the cutting device, maintaining constant the advancement velocity of the metallic belt upstream and downstream of the cutting device.

Abstract: A nozzle for the injection of solid fuel in dust form into a combustion chamber, to be installed in correspondence with the outlet of a burner coaxially to the longitudinal axis of the burner, comprising a stationary annular part divided into coal ducts of a circumferential width that decreases towards outlet section to form coal-dust-rich air streams, a central duct for a coal-dust-poor air stream sideways delimited by the coal ducts and having an outlet end, a central member that is axially mobile within the central duct, for varying the cross section of a central passage delimited by the stationary annular part at the outlet end. Air ducts for the coal-dust-poor air stream are formed between each pair of adjacent coal ducts in the stationary annular part communicating with the central duct and having a circumferential width increasing toward the outlet end.

Abstract: A low NOx burner comprising ducts for the primary (6), secondary (7) and tertiary air (14), arranged coaxially around its longitudinal axis, for supplying of the primary, secondary and tertiary air, respectively, to a combustion chamber (3), means for accumulation of the air (5), means to give vorticity to the primary, secondary and tertiary air (11, 15, 27) installed in the respective ducts, means for supply of fuel (23, 32, 43) arranged within said ducts to inject the fuel into said combustion chamber. The axial swirler for the secondary air (11) is formed by a plurality of blades each of which is made up of a stationary part (11a) and a mobile part (11b) connected to actuator means capable of moving it in an angular direction to give an air outlet angle of between 30.degree. and 60.degree.. The axial swirler for the tertiary air is conical in shape and has fixed blades. On the tertiary air duct a passage (16) is formed for supply of secondary and tertiary air.