Abstract: A system is disclosed for manufacturing a dental workpiece. The system may have a subtractive machine configured to manufacture a base of a dental device from a material blank, and an additive machine configured to manufacture a top of the dental device by adding material onto a surface of the base. The system may also have a controller in communication with the subtractive machine and the additive machine. The controller may be programmed to receive digital data corresponding to a mouth of a particular patient, and to control operation of the subtractive machine to customize the base based on the digital data.