Abstract: A method processes data for evaluating quality level of an original dataset. The original dataset is obtained from an automated sequencing of a chain of nucleotides and represents a plurality of total mapped reads. The method includes sampling of a plurality of total mapped reads of the original dataset to produce a subset of mapped reads. The method also includes computing a dispersion indicator for the subset. The dispersion indicator represents divergence between an actual read count intensity and a theoretical read count intensity. The actual read count corresponds to the number of sampled mapped reads. The theoretical read count corresponds to a theoretical number of sampled mapped reads, which does not depend on the current sampling.