Patents by Inventor Marco Antonio Santini

Marco Antonio Santini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable pharmaceutical compositions with docetaxel
    Patent number: 8304450
    Abstract: The invention relates to pharmaceutical compositions comprising anhydrous(2R,3S)4-acetoxy-2-a-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I)(docetaxel) and 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1,7?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il (2R,3S)3-benzoylamino-2-hydroxy-3-phenylpropionate (II) (paclitaxel), methods for treating neoplastic tumors using anhydrous docetaxel and paclitaxel, and a process for the preparation of the anhydrous docetaxel and paclitaxel.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: November 6, 2012
    Assignees: Quiral Quimica Do Brasil S.A., Biorganica Ltda.
    Inventors: Marco Antônio Santini, Antônio Machado, Aurélio Maranduba, Eneida Guimarães, Marcio Santiago Junior, Maria Silva
  • Process for the preparation of concentrated, sterile injectable solutions containing docetaxel
    Patent number: 7838551
    Abstract: This invention describes a process for the production of ANHYDROUS active pharmaceutical ingredients (APIs); a process for the preparation of HYDRATED active pharmaceutical ingredients, a process for the preparation of sterile and stable injectable solutions, and their use, more specifically, APIs which are taxane derivatives, especially (2R,3S) 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxy carbonylamino-2-hydroxy-3-phenylpropionate (I); 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1,7?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-benzoylamino-2-hydroxy-3-phenylpropionate (II), and particularly 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1, 7-?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate tri-hydrate (III).
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: November 23, 2010
    Assignees: Quiral Quimica do Basil S.A., Biorganica LTDA.
    Inventors: Marco Antônio Santini, Antônio Machado, Aurélio Maranduba, Eneida Guimarães, Marcio Santiago Junior, Maria Silva
  • PROCESS FOR THE PREPARATION OF ANHYDROUS AND HYDRATED ACTIVE PHARMACEUTICAL INGREDIENTS (APIS); STABLE PHARMACEUTICAL COMPOSITIONS PREPARED FROM THE SAME AND USES OF SAID COMPOSITIONS
    Publication number: 20090069409
    Abstract: The invention relates to pharmaceutical compositions comprising anhydrous(2R,3S)4-acetoxy-2-a-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I)(docetaxel) and 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1,7?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il (2R, 3S)3-benzoylamino-2-hydroxy-3-phenylpropionate (II) (paclitaxel), methods for treating neoplastic tumors using anhydrous docetaxel and paclitaxel, and a process for the preparation of the anhydrous docetaxel and paclitaxel.
    Type: Application
    Filed: August 7, 2008
    Publication date: March 12, 2009
    Applicants: QUIRAL QUIMICA DO BRASIL, BIORGANICA LTDA.
    Inventors: Marco Antonio SANTINI, Antonio Machado, Aurelio Maranduba, Eneida Guimaraes, Marcio Santiago Junior, Maria Silva
  • Process For The Preparation Of Anhydrous And Hydrated Active Pharmaceutical Ingredients (Apis); Stable Pharmaceutical Compositions Prepared From The Same And Uses Of Said Compositions
    Publication number: 20080051450
    Abstract: This invention describes a process for the production of ANHYDROUS active pharmaceutical ingredients (APIs); a process for the preparation of HYDRATED active pharmaceutical ingredients, a process for the preparation of sterile and stable injectable solutions, and their use, more specifically, APIs which are taxane derivatives, especially (2R,3S) 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I); 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1, 7?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-benzoylamino-2-hydroxy-3-phenylpropionate (II), and particularly 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate tri-hydrate (III).
    Type: Application
    Filed: December 10, 2004
    Publication date: February 28, 2008
    Applicant: BIORGANICA LTDA.
    Inventors: Marco Antonio Santini, Antonio Machado, Aurelio Maranduba, Eneida Guimaraes, Marcio Santiago, Maria Silva