Patents by Inventor Marco Berna

Marco Berna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Slow-release solid oral compositions
    Patent number: 10702482
    Abstract: The present invention relates to a slow-release solid oral nutraceutical and/or pharmaceutical composition comprising: a core containing a donor of methyl groups and at least one pharmaceutically acceptable excipient, and an outer coating containing shellac and/or a pharmaceutically acceptable salt thereof, magnesium stearate, and at least one pharmaceutically acceptable excipient. The coating of said solid oral composition allows the donor of methyl groups, preferably SAMe and/or a pharmaceutically acceptable salt thereof, to cross intact the gastric barrier and release the same in a continuous and complete manner along the entire digestive tract.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: July 7, 2020
    Assignee: GNOSIS SPA
    Inventors: Daniele Giovannone, Niccolò Miraglia, Marco Berna
  • SALT OF (SS)-ADENOSYL METHIONINE WITH INOSITOL HEXAPHOSPHATE, AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20200165287
    Abstract: The invention relates to the salt of (SS)-adenosyl methionine with myo-inositol 1,2,3,4,5,6 hexakisphosphate, and pharmaceutical, nutraceutical or veterinary formulations containing it.
    Type: Application
    Filed: July 3, 2018
    Publication date: May 28, 2020
    Applicant: GNOSIS S.p.A.
    Inventors: Auro Roberto TAGLIANI, Daniele GREGORI, Davide BIANCHI, Marco BERNA, Federica COLZANI
  • SALT OF (SS)-ADENOSYL METHIONINE WITH INOSITOL HEXAPHOSPHATE, AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20190010182
    Abstract: The invention relates to the salt of (SS)-adenosyl methionine with myo-inositol 1,2,3,4,5,6 hexakisphosphate, and pharmaceutical, nutraceutical or veterinary formulations containing it.
    Type: Application
    Filed: October 9, 2017
    Publication date: January 10, 2019
    Applicant: GNOSIS S.p.A.
    Inventors: Auro Roberto TAGLIANI, Daniele GREGORI, Davide BIANCHI, Marco BERNA, Federica COLZANI
  • SLOW-RELEASE SOLID ORAL COMPOSITIONS
    Publication number: 20160287519
    Abstract: The present invention relates to a slow-release solid oral nutraceutical and/or pharmaceutical composition comprising: a core containing a donor of methyl groups and at least one pharmaceutically acceptable excipient, and an outer coating containing shellac and/or a pharmaceutically acceptable salt thereof, magnesium stearate, and at least one pharmaceutically acceptable excipient. The coating of said solid oral composition allows the donor of methyl groups, preferably SAMe and/or a pharmaceutically acceptable salt thereof, to cross intact the gastric barrier and release the same in a continuous and complete manner along the entire digestive tract.
    Type: Application
    Filed: November 6, 2014
    Publication date: October 6, 2016
    Applicant: GNOSIS SPA
    Inventors: Daniele GIOVANNONE, Niccolò MIRAGLIA, Marco BERNA
  • STERILE S-ADENOSYL METHIONINE WITH A HIGH CONTENT OF ACTIVE ISOMER FOR INJECTABLE SOLUTIONS, AND PROCEDURE FOR OBTAINING IT
    Publication number: 20160271063
    Abstract: S-adenosyl methionine, and the salts and complexes thereof, in the form of a spray-dried sterile powder which has a pharmacologically active enantiomer content exceeding 70% and a water residue below 2.5% by weight.
    Type: Application
    Filed: March 19, 2014
    Publication date: September 22, 2016
    Applicant: Gnosis S.p.A.
    Inventors: Marco Berna, Auro Tagliani, Daniele Gregori
  • Stable salts of S-adenosylmethionine and process for the preparation thereof
    Patent number: 8258115
    Abstract: The present invention refers to new salts of S-adenosyknethionine (SAMe) with improved stability and containing at least 70% by weight of SAMe.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: September 4, 2012
    Assignee: Gnosis SpA
    Inventors: Ermanno Valoti, Daniele Giovannone, Marco Berna
  • STABLE SALTS OF S-ADENOSYLMETHIONINE AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20100184715
    Abstract: The present invention refers to new salts of S-adenosyknethionine (SAMe) with improved stability and containing at least 70% by weight of SAMe.
    Type: Application
    Filed: October 22, 2007
    Publication date: July 22, 2010
    Applicant: GNOSIS SPA
    Inventors: Ermanno Valoti, Daniele Giovannone, Marco Berna
  • Process for the preparation of pharmaceutically acceptable salts of (R,S)-S-adenosyl-L-methionine
    Patent number: 6958233
    Abstract: The present invention relates to a process for the preparation of pharmaceutically acceptable salts of (R,S)-S-adenosyl-L-methionine and allows to obtain the salified (R)-(+)-S-adenosyl-L-methionine diasteroisomer in amounts lower than or equal to 3% with respect to the salified (S)-(+)-S-adenosyl-L-methionine diastereoisomer; the salts that can be obtained by the process of the invention keep their configuration stable in time.
    Type: Grant
    Filed: May 13, 2002
    Date of Patent: October 25, 2005
    Assignee: Chementecno S.r.l.
    Inventors: Marco Berna, Lino Sivieri, Gianni Santambrogio, Ermanno Valoti
  • Process for the preparation of pharmaceutically acceptable salts of (R,S)-S-adenosyl-L-methionine
    Publication number: 20020173012
    Abstract: The present invention relates to a process for the preparation of pharmaceutically acceptable salts of (SS,RS)-S-adenosyl-L-methionine and allows to obtain the salified (RS)-(+)-S-adenosyl-L-methionine diastereoisomer in amounts lower than or equal to 3% with respect to the salified (SS)-(+)-S-adenosyl-L-methionine diastereoisomer; the salts that can be obtained by the process of the invention keep their configuration stable in time.
    Type: Application
    Filed: May 13, 2002
    Publication date: November 21, 2002
    Inventors: Marco Berna, Lino Sivieri, Gianni Santambrogio, Ermanno Valoti
  • Process for the preparation of pharmaceutically acceptable salts of (SS,RS) -s-adenosyl-l-methionine
    Publication number: 20020010147
    Abstract: The present invention relates to a process for the preparation of pharmaceutically acceptable salts of (SS,RS)-S-adenosyl-L-methionine and allows to obtain the salified (RS)-(+)-S-adenosyl-L-methionine diastereoisomer in amounts lower than or equal to 3% with respect to the salified (SS)-(+)-S-adenosyl-L-methionine diastereoisomer; the salts that can be obtained by the process of the invention keep their configuration stable in time.
    Type: Application
    Filed: April 11, 2001
    Publication date: January 24, 2002
    Applicant: CHEMENTECNO S.R.L.
    Inventors: Marco Berna, Lino Sivieri, Gianni Santambrogio, Ermanno Valoti