Abstract: Disclosed herein is a method comprising a) forming a mixture comprising: i) an aromatic nitrogen-containing compound, ii) a saccharide; and iii) a silica precursor; b) adding an amount of water to the mixture to initiate a condensation reaction; and c) precipitating a plurality of amorphous silica-based nanoparticles. Also disclosed herein is a plurality of amorphous silica-based nanoparticles, scaffolds, and devices comprising the same, in addition to methods of using the same.

Abstract: Provided herein are methods and compositions for treating nephropathic conditions such as chronic kidney disease, as well as phosphate concentration disorders and myopathy related to phosphate concentration disorders. The methods and compositions include administering a therapeutically effective amount of L-BAIBA ((S)-?-aminoisobutyric acid) to a subject in need thereof.