Patents by Inventor Marco CAPOGROSSO
Marco CAPOGROSSO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240399152Abstract: Disclosed herein are methods for treating impairment of a limb in a subject. Particular methods comprise applying a therapeutically effective amount of an electrical stimulus to dorsal roots, dorsal rootlets, or dorsal root ganglia, of sensory neurons innervating the limb of the subject, wherein the impairment is a motor impairment and/or a proprioception impairment due to neurological disorder or injury, the electrical stimulus is applied with one or more electrodes controlled by a neurostimulator, and the one or more electrodes are implanted in the epidural space at the dorsolateral aspect of the spinal cord and proximate to the dorsal roots or dorsal rootlets of the sensory neurons innervating the limb of the subject, or the one or more electrodes are implanted proximate to dorsal root ganglia of sensory neurons innervating the limb of the subject.Type: ApplicationFiled: September 9, 2022Publication date: December 5, 2024Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, CARNEGIE MELLON UNIVERSITYInventors: Marc Philip Powell, Marco Capogrosso, Douglas J. Weber, Nikhil Verma, Peter C. Gerszten, Elvira Pirondini, Erynn Sorensen, Erick Fabrizio Carranza Urquizo, Lee Fisher
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Publication number: 20240225860Abstract: Methods are disclosed for stimulating asynchronous and stochastic neural activity in a subject in need thereof. In some embodiments, the methods are used to provide asynchronous and stochastic neural activity in a limb of a subject with an amputation of the limb, for example, in a method of controlling the prosthetic limb of the subject.Type: ApplicationFiled: May 3, 2022Publication date: July 11, 2024Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, The Regents of the University of MichiganInventors: Beatrice Barra, Lee Erik Bartholomew Fisher, Marco Capogrosso, Ehsan Mirzakhalili, Scott Lempka
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Patent number: 11992684Abstract: The present invention relates to systems and methods for planning and/or providing neuromodulation One example system includes a stimulation related basic data storage module for storing stimulation related basic data, a stimulation related response data storage module for storing the stimulation related response data, a transfer module configured such that the stimulation related basic data are linked with and/or translated into the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, and an analysis module configured and arranged such that the digital characteristic map is analyzed automatically.Type: GrantFiled: November 29, 2018Date of Patent: May 28, 2024Assignees: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), ONWARD MEDICAL N.V.Inventors: Karen Minassian, Fabien Wagner, Marco Capogrosso, Gregoire Courtine, Robin Brouns, Jurriaan Bakker, Andre Kleibeuker, Bert Bakker, Vincent Delattre
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Patent number: 11571565Abstract: The present invention relates to an electrode array for neuromodulation, comprising a first electrode section with more than two electrodes being arranged parallel and densely packed in the first electrode section, further comprising a second electrode section with more electrodes than in the first electrode section, the electrodes in the second electrode section being arranged symmetrically with respect to the longitudinal axis and transversal offset to each other. Furthermore, the present invention relates to a lead paddle and a neuromodulation system.Type: GrantFiled: May 30, 2019Date of Patent: February 7, 2023Assignee: Onward Medical N.V.Inventors: Marco Capogrosso, Fabien Wagner, Gregoire Courtine, Vincent Delattre, Karen Minassian, Bert Bakker, Jocelyne Bloch, Nathan Greiner, Damien Ganty, Sjaak Deckers, Edoardo Paoles
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Patent number: 11511116Abstract: The present invention relates to systems and methods for planning and/or providing neuromodulation. An example system includes a first data input module for stimulation related basic data, a second data input module for stimulation related response data, a transfer module configured and arranged such that the stimulation related basic data received by the data input module are linked and/or translated into and/or with the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, and a mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, which describes an interrelation between the stimulation related basic data and the stimulation related response data and the transfer data.Type: GrantFiled: November 29, 2018Date of Patent: November 29, 2022Assignees: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), ONWARD Medical N.V.Inventors: Fabien Wagner, Karen Minassian, Marco Capogrosso, Gregoire Courtine, Robin Brouns, Jurriaan Bakker, Andre Kleibeuker, Bert Bakker, Vincent Delattre
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Patent number: 11420056Abstract: The present invention relates to methods and systems for planning and/or providing neuromodulation. An example system comprises a neurostimulator comprising a least one electrode, functional mapping module configured and arranged such that based on stimulation related basic data and stimulation related response data and transfer data a digital characteristic functional map is generated and/or provided, which describes the interrelation between the stimulation related basic data and the stimulation related response data and the transfer data, and analysis module configured and arranged such that the digital characteristic functional map may be analyzed in connection with neurostimulation provided by the neurostimulator such that the provided neurostimulation and its response may be analyzed on the basis of the functional map and that on the basis of this analysis a placement analysis of a placement of the electrode is provided.Type: GrantFiled: November 29, 2018Date of Patent: August 23, 2022Assignees: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), ONWARD MEDICAL N.V.Inventors: Marco Capogrosso, Karen Minassian, Fabien Wagner, Gregoire Courtine, Miroslav Caban, Robin Brouns, Jurriaan Bakker, Andre Kleibeuker, Bert Bakker, Vincent Delattre
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Patent number: 11413459Abstract: The present invention relates to systems and methods for planning and/or providing neurostimulation for a patient. An example system includes a pathological spinal cord map storage module for storing at least one pathological spinal cord map describing activation of a spinal cord of a patient, a healthy spinal cord map storage module for storing at least one reference map describing physiological activation of the spinal cord of at least one healthy subject, an analysis module for generating a deviation map, the deviation map describing an activation difference between the pathological spinal cord map and the reference map, and a compensation module for calculating, based on the deviation map, a neurostimulation protocol for compensating the activation difference.Type: GrantFiled: November 29, 2018Date of Patent: August 16, 2022Assignees: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), ONWARD MEDICAL B.V.Inventors: Flavio Raschella, Silvestro Misera, Gregoire Courtine, Tomislav Milekovic, Fabien Wagner, Marco Capogrosso, Jurriaan Bakker, Robin Brouns, Vincent Delattre
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Publication number: 20220143407Abstract: A system for providing neuromodulation, especially neurostimulation, comprising a neuromodulator for neuromodulation of a cervical spinal cord, a dorsal neuromodulation array for providing neuromodulation to the cervical spinal cord, a sensor for measuring movements and/or muscle activations of a patient, a mapping module, which is configured and arranged for implementing a mapping between desired muscle activation patterns and neuromodulation parameters, and a processing module which is configured and arranged for processing signals provided by the sensor, further forwarding the processed signals to the mapping module and directing the mapping module output to the neuromodulator.Type: ApplicationFiled: February 11, 2020Publication date: May 12, 2022Inventors: Katie ZHUANG, Beatrice BARRA, Elena LOSANNO, Gregoire COURTINE, Marco CAPOGROSSO
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Publication number: 20210213292Abstract: The present invention relates to systems and methods for planning and/or providing neuromodulation One example system includes a stimulation related basic data storage module for storing stimulation related basic data, a stimulation related response data storage module for storing the stimulation related response data, a transfer module configured such that the stimulation related basic data are linked with and/or translated into the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, and an analysis module configured and arranged such that the digital characteristic map is analyzed automatically.Type: ApplicationFiled: March 29, 2021Publication date: July 15, 2021Inventors: Karen MINASSIAN, Fabien WAGNER, Marco CAPOGROSSO, Gregoire COURTINE, Robin BROUNS, Jurriaan BAKKER, Andre KLEIBEUKER, Bert BAKKER, Vincent DELATTRE
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Publication number: 20210170177Abstract: The present invention relates to systems and methods for planning and/or providing neuromodulation One example system includes a stimulation related basic data storage module for storing stimulation related basic data, a stimulation related response data storage module for storing the stimulation related response data, a transfer module configured such that the stimulation related basic data are linked with and/or translated into the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, and an analysis module configured and arranged such that the digital characteristic map is analyzed automatically.Type: ApplicationFiled: November 29, 2018Publication date: June 10, 2021Inventors: Karen MINASSIAN, Fabien WAGNER, Marco CAPOGROSSO, Gregoire COURTINE, Robin BROUNS, Jurriaan BAKKER, Andre KLEIBEUKER, Bert BAKKER, Vincent DELATTRE
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Publication number: 20210170178Abstract: The present invention relates to systems and methods for planning and/or providing neuromodulation. An example system includes a first data input module for stimulation related basic data, a second data input module for stimulation related response data, a transfer module configured and arranged such that the stimulation related basic data received by the data input module are linked and/or translated into and/or with the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, and a mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, which describes an interrelation between the stimulation related basic data and the stimulation related response data and the transfer data.Type: ApplicationFiled: November 29, 2018Publication date: June 10, 2021Inventors: Fabien WAGNER, Karen MINASSIAN, Marco CAPOGROSSO, Gregoire COURTINE, Robin BROUNS, Jurriaan BAKKER, Andre KLEIBEUKER, Bert BAKKER, Vincent DELATTRE
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Patent number: 10981004Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: GrantFiled: July 10, 2019Date of Patent: April 20, 2021Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Jocelyne Bloch, Grégoire Courtine, Nikolaus Wenger, Silvestro Micera, Marco Capogrosso
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Publication number: 20200391030Abstract: The present invention relates to methods and systems for planning and/or providing neuromodulation. An example system comprises a neurostimulator comprising a least one electrode, functional mapping module configured and arranged such that based on stimulation related basic data and stimulation related response data and transfer data a digital characteristic functional map is generated and/or provided, which describes the interrelation between the stimulation related basic data and the stimulation related response data and the transfer data, and analysis module configured and arranged such that the digital characteristic functional map may be analyzed in connection with neurostimulation provided by the neurostimulator such that the provided neurostimulation and its response may be analyzed on the basis of the functional map and that on the basis of this analysis a placement analysis of a placement of the electrode is provided.Type: ApplicationFiled: November 29, 2018Publication date: December 17, 2020Inventors: Marco CAPOGROSSO, Karen MINASSIAN, Fabien WAGNER, Gregoire COURTINE, Miroslav CABAN, Robin BROUNS, Jurriaan BAKKER, Andre KLEIBEUKER, Bert BAKKER, Vincent DELATTRE
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Publication number: 20200384272Abstract: The present invention relates to a system (10) for planning and/or providing neurostimulation for a patient, comprising a pathological spinal cord map storage module (48) for storing at least one pathological spinal cord map (49) describing the activation of the spinal cord of a patient, a healthy spinal cord map storage module (50) for storing at least one reference map (51) describing physiological activation of the spinal cord of at least one healthy subject, an analysis module (42) configured and arranged such that the pathological spinal cord map and the reference map can be compared and/or analyzed automatically such that a deviation map is created, the deviation map describing the difference between the pathological spinal cord map and the reference map, and a compensation module (52) which is configured and arranged to calculate on the basis of the deviation map a neurostimulation protocol for compensating the activation.Type: ApplicationFiled: November 29, 2018Publication date: December 10, 2020Inventors: Flavio RASCHELLA, Silvestro MISERA, Gregoire COURTINE, Tomislav MILEKOVIC, Fabien WAGNER, Marco CAPOGROSSO, Jurriaan BAKKER, Robin BROUNS, Vincent DELATTRE
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Patent number: 10668280Abstract: Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a first mode where one or more nerve fibers are not stimulated, and during a second mode where the one or more nerve fibers are stimulated. Delivery timing of electrical stimulation may be closed-loop controlled based on current motor cortex activity and the motor cortex activity recorded previously during both the first and second modes.Type: GrantFiled: November 1, 2016Date of Patent: June 2, 2020Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Tomislav Milekovic, Marco Capogrosso, Gregoire Courtine, Eduardo Martin Moraud, Fabien Wagner, Jerome Gandar
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Publication number: 20200086116Abstract: The present invention refers to a system for stimulation of the spinal cord for the rehabilitation of motor function in subjects with spinal cord injury or other motor disorders. Said system comprises a programmable implantable pulse generator (IPG), operatively connected to deliver current pulses to one or more multi-electrode arrays, wherein said IPG is adapted to deliver to said multi-electrode array a stimulation characterized by a frequency comprised between 20 and 1200 Hz and an amplitude comprised between 0.1 motor threshold amplitude and 1.5 motor threshold amplitude. The use of such system for facilitating locomotor functions or upper limb movements in a subject with neuromotor impairments is also within the scope of the invention.Type: ApplicationFiled: December 19, 2017Publication date: March 19, 2020Inventors: Emanuele FORMENTO, Marco CAPOGROSSO, Silvestro MICERA, Grégoire COURTINE, Karen MINASSIAN
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Publication number: 20190366077Abstract: The present invention relates to an electrode array for neuromodulation, comprising a first electrode section with more than two electrodes being arranged parallel and densely packed in the first electrode section, further comprising a second electrode section with more electrodes than in the first electrode section, the electrodes in the second electrode section being arranged symmetrically with respect to the longitudinal axis and transversal offset to each other. Furthermore, the present invention relates to a lead paddle and a neuromodulation system.Type: ApplicationFiled: May 30, 2019Publication date: December 5, 2019Inventors: Marco Capogrosso, Fabien Wagner, Gregoire Courtine, Vincent Delattre, Karen Minassian, Bert Bakker, Jocelyne Bloch, Nathan Greiner, Damien Ganty, Sjaak Deckers, Edoardo Paoles
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Publication number: 20190344075Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: ApplicationFiled: July 10, 2019Publication date: November 14, 2019Inventors: Jocelyne BLOCH, Grégoire COURTINE, Nikolaus WENGER, Silvestro MICERA, Marco CAPOGROSSO
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Patent number: 10391309Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: GrantFiled: December 21, 2016Date of Patent: August 27, 2019Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Jocelyne Bloch, Grégoire Courtine, Nikolaus Wenger, Silvestro Micera, Marco Capogrosso
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Patent number: D907206Type: GrantFiled: November 29, 2018Date of Patent: January 5, 2021Assignee: GTX MEDICAL B.V.Inventors: Damien Ganty, Egbertus Bakker, Jacobus Deckers, Edoardo Paoles, Vincent Delattre, Jocelyne Bloch, Grégoire Courtine, Marco Capogrosso, Fabien Wagner, Nathan Greiner, Karen Minassian