Patents by Inventor Marco DE DOMINICI

Marco DE DOMINICI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEOLYSIS-TARGETING CHIMERAS
    Publication number: 20220002291
    Abstract: The present disclosure provides compounds of the formula (I) wherein these compounds contain a ligand which binds to one or more target proteins such as CDK4 or CDK6 and a ligand which binds to the machinery associated with the ubiquitinating protein machinery. Also provided herein are methods of using these compounds in compositions or methods of treating patients with these compounds for the treatment of a disease or disorders such as cancer.
    Type: Application
    Filed: October 30, 2019
    Publication date: January 6, 2022
    Applicants: The Wistar Institute of Anatomy and Biology, Thomas Jefferson University
    Inventors: Joseph SALVINO, Bruno CALABRETTA, Marco DE DOMINICI, You Cai XIAO