Abstract: A fluidic device for detecting a target molecule in a fluid sample comprising a blocking chamber in fluidic communication with a detection chamber forming a blocking-detection chamber pair, the blocking chamber provided with at least one reagent for binding a non-target molecule in the sample, the blocking chamber adapted to maintain at least a portion of the bound non-target molecule within the blocking chamber, the detection chamber comprising at least one reagent for binding a target-molecule such that the target-molecule may be detected. The device comprises a combination detection chamber adapted to receive at least one reagent for binding both target and non-target molecules such that the combination of target and non-target molecules may be detected by binding to a detector.

Abstract: Disclosed herein is a biosensor for optical detection of Brownian relaxation dynamics of magnetic particles measured by light transmission. The magnetic particles can be functionalized with biological ligands for the detection of target analytes in a sample. The setup may be implemented in a disc and optical pick-up head configuration.

Abstract: Disclosed herein is a biosensor for optical detection of Brownian relaxation dynamics of magnetic particles measured by light transmission. The magnetic particles can be functionalized with biological ligands for the detection of target analytes in a sample.

Abstract: Disclosed herein is a biosensor for optical detection of Brownian relaxation dynamics of magnetic particles measured by light transmission. The magnetic particles can be functionalized with biological ligands for the detection of target analytes in a sample.

Abstract: Disclosed herein is a biosensor for optical detection of Brownian relaxation dynamics of magnetic particles measured by light transmission. The magnetic particles can be functionalized with biological ligands for the detection of target analytes in a sample. The setup may be implemented in a disc and optical pick-up head configuration.

Abstract: A system and a method for the controlled manipulation of any number of magnetic particles in solution are shown. The system and the method of the present invention are based on the employment of magnetic conduits properly structured in order to inject, move and annihilate with high precision magnetic domain walls and on the fact that said magnetic domain walls exert a high attraction force on magnetic particles. The injection, movement and annihilation of domain walls along said magnetic conduit result, therefore, in the trapping, movement and release, respectively, of single magnetic particles placed in solution in proximity of said magnetic conduits. The devices of the present invention guarantee the possibility of a digital transfer of magnetic particles along conduits formed by linear segments as well as high control and nanometric precision in the manipulation of said magnetic particles on curved conduits.

Abstract: A system and a method for the controlled manipulation of any number of magnetic particles in solution are shown. The system and the method of the present invention are based on the employment of magnetic conduits properly structured in order to inject, move and annihilate with high precision magnetic domain walls and on the fact that said magnetic domain walls exert a high attraction force on magnetic particles. The injection, movement and annihilation of domain walls along said magnetic conduit result, therefore, in the trapping, movement and release, respectively, of single magnetic particles placed in solution in proximity of said magnetic conduits. The devices of the present invention guarantee the possibility of a digital transfer of magnetic particles along conduits formed by linear segments as well as high control and nanometric precision in the manipulation of said magnetic particles on curved conduits.