Patents by Inventor Marco E. Bianchi

Marco E. Bianchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STRUCTURE AND FUNCTION OF THE SALICYCLIC ACID BINDING SITES ON HUMAN HMGB1 AND METHODS OF USE THEREOF FOR THE RATIONAL DESIGN OF BOTH SALICYCLIC ACID DERIVATIVES AND OTHER AGENTS THAT ALTER ANIMAL AND PLANT HMGBS ACTIVITIES
    Publication number: 20180045715
    Abstract: Compositions and methods for identifying agents which 1) mimic salicyclic acid binding to human, animal and plant high mobility group box proteins or 2) alter activities of these HMGBs by binding in or around their salicyclic acid-binding sites and agents so identified are disclosed.
    Type: Application
    Filed: February 12, 2016
    Publication date: February 15, 2018
    Inventors: Daniel F. Klessig, Sang-Wook Park, Hyong Woo Choi, Frank C. Schroeder, Gaetano T. Montelione, Keith Hamilton, Swapna Gurla, Fei Song, Marco E. Bianchi
  • Treatment and prevention of cancer with HMGB1 antagonists
    Patent number: 9561274
    Abstract: Embodiments provided herewith relate to methods and compositions for treating or preventing cancer. More particularly, several embodiments are drawn to treating or preventing malignant mesothelioma with antagonists of high-mobility group box 1 (HMGB1).
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: February 7, 2017
    Assignee: UNIVERSITY OF HAWAII
    Inventors: Haining Yang, Michele Carbone, Marco E. Bianchi
  • TREATMENT AND PREVENTION OF CANCER WITH HMGB1 ANTAGONISTS
    Publication number: 20140127134
    Abstract: Embodiments provided herein relate to methods and compositions for treating or preventing cancer. More particularly, several embodiments are drawn to treating or preventing malignant mesothelioma with antagonists of HMGB1.
    Type: Application
    Filed: June 7, 2012
    Publication date: May 8, 2014
    Inventors: Haining Yang, Michele Carbone, Marco E. Bianchi
  • HMGB1 protein inhibitorsand/or antagonists for the treatment of vascular diseases
    Patent number: 8058239
    Abstract: The use of HMG box-binding molecules and molecules having sequence homology with HMG box for the preparation of therapeutic agents for the treatment of vascular diseases is described.
    Type: Grant
    Filed: January 2, 2008
    Date of Patent: November 15, 2011
    Assignee: Bio3 Research S.r.l.
    Inventors: Marco E. Bianchi, Tiziana Bonaldi, Paola Scaffidi, Susanne Mueller, Bernard Degryse
  • HMGB1 PROTEIN INHIBITORS AND/OR ANTAGONISTS FOR THE TREATMENT OF VASCULAR DISEASES
    Publication number: 20100297107
    Abstract: A method of treating vascular diseases by administering an antagonist molecule that inhibits the interaction between a protein of the HMG box family and a receptor for the protein of the HMG box family.
    Type: Application
    Filed: February 17, 2010
    Publication date: November 25, 2010
    Applicants: BIO3 RESEARCH SRL, MARCO E. BIANCHI
    Inventors: Marco E. BIANCHI, Tiziana Bonaldi, Paola Scaffidi, Susanne Mueller, Bernard Degryse
  • HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases
    Patent number: 7754217
    Abstract: The use of HMG box-binding molecules and molecules having sequence homology with HMG box for the preparation of therapeutic agents for the treatment of vascular diseases is described.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: July 13, 2010
    Assignees: BIO3 Research SRL
    Inventors: Marco E. Bianchi, Tiziana Bonaldi, Paola Scaffidi, Susanne Mueller, Bernard Degryse
  • HMGB1 PROTEIN INHIBITORS AND/OR ANTAGONISTS FOR THE TREATMENT OF VASCULAR DISEASES
    Publication number: 20100172896
    Abstract: A method of inhibiting atherosclerosis by administering a molecule that binds a protein of the HMG box family. Also, a method of treating vascular diseases by administering an antagonist molecule to inhibit the interaction between a protein of the HMG box family and a receptor for the protein of the HMG box family.
    Type: Application
    Filed: February 17, 2010
    Publication date: July 8, 2010
    Applicants: BIO3 RESEARCH SRL
    Inventors: Marco E. Bianchi, Tiziana Bonaldi, Paola Scaffidi, Susanne Mueller, Bernard Degryse
  • Therapeutic Agents for the Treatment of Hmgb1-Related Pathologies
    Publication number: 20080305073
    Abstract: The present invention relates to the use of synthetic double-stranded nucleic acid or nucleic acid analogue molecules with a bent shape structure for the prevention and treatment of pathologies induced directly or indirectly by the HMGB1 protein.
    Type: Application
    Filed: July 4, 2005
    Publication date: December 11, 2008
    Inventors: Domenico G. Barone, Marco E. Bianchi, Enrico M. Bucci, Silvano Fumero, Margherita Valente, Roberto Sapio, Domenica Musumeci
  • HMGB1 PROTEIN INHIBITORSAND/OR ANTAGONISTS FOR THE TREATMENT OF VASCULAR DISEASES
    Publication number: 20080171052
    Abstract: The use of HMG box-binding molecules and molecules having sequence homology with HMG box for the preparation of therapeutic agents for the treatment of vascular diseases is described
    Type: Application
    Filed: January 2, 2008
    Publication date: July 17, 2008
    Inventors: MARCO E. BIANCHI, TIZIANA BONALDI, PAOLA SCAFFIDI, SUSANNE MUELLER, BERNARD DEGRYSE
  • Hmgb1 protein inhibitors and/or antagonists for the treatment of vascular diseases
    Publication number: 20040136979
    Abstract: The use of HMG box-binding molecules and molecules having sequence homology with HMG box for the reparation of therapeutic agents for the treatment of vascular diseases is described.
    Type: Application
    Filed: February 17, 2004
    Publication date: July 15, 2004
    Inventors: Marco E Bianchi, Tiziana Bonaldi, Paola Scaffidi, Susanne Mueller, Bernard Degryse