Patents by Inventor Marco Galvagni

Marco Galvagni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF TRIAZOLE AND SALT THEREOF
    Publication number: 20180230151
    Abstract: An improved process for the preparation of Triazole and salts thereof, a key intermediate for the synthesis of Sitagliptine is disclosed.
    Type: Application
    Filed: February 10, 2017
    Publication date: August 16, 2018
    Inventors: Marco Galvagni, Ennio Grendele, Giovanni Lora
  • Process for the preparation of triazole and salt thereof
    Patent number: 10047094
    Abstract: An improved process for the preparation of Triazole and salts thereof, a key intermediate for the synthesis of Sitagliptine is disclosed.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: August 14, 2018
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Marco Galvagni, Ennio Grendele, Giovanni Lora
  • Convenient process for the preparation of statins
    Patent number: 9932361
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: April 3, 2018
    Inventors: Ottorino De Lucchi, Stefano Tartaggia, Clark Ferrari, Marco Galvagni, Marta Pontini, Stefano Fogal, Riccardo Motterle, Rosa Maria Moreno, Alex Comely
  • CONVENIENT PROCESS FOR THE PREPARATION OF STATINS
    Publication number: 20160200744
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Application
    Filed: March 8, 2016
    Publication date: July 14, 2016
    Inventors: Ottorino DE LUCCHI, Stefano TARTAGGIA, Clark FERRARI, Marco GALVAGNI, Marta PONTINI, Stefano FOGAL, Riccardo MOTTERLE, Rosa Maria MORENO, Alex COMELY
  • Convenient process for the preparation of statins
    Patent number: 9315470
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: April 19, 2016
    Assignee: F.I.S.—Fabbrica Italiana Sintetiei S.p.A.
    Inventors: Ottorino De Lucchi, Stefano Tartaggia, Clark Ferrari, Marco Galvagni, Marta Pontini, Stefano Fogal, Riccardo Motterle, Rosa Maria Moreno, Alex Comely
  • Convenient Process for the Preparation of Statins
    Publication number: 20150344439
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Application
    Filed: February 11, 2014
    Publication date: December 3, 2015
    Inventors: Ottorino DE LUCCHI, Stefano TARTAGGIA, Clark FERRARI, Marco GALVAGNI, Marta PONTINI, Stefano FOGAL, Riccardo MOTTERLE, Rosa Maria MORENO, Alex COMELY
  • Process for the preparation of olopatadine
    Patent number: 8980939
    Abstract: A process for the preparation of olopatadine hydrochloride starting from an advanced intermediate.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: March 17, 2015
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Andrea Castellin, Clark Ferrari, Marco Galvagni
  • Process for the preparation of olopatadine
    Patent number: 8871953
    Abstract: The present invention relates to a novel process for the preparation of olopatadine hydrochloride starting from an advanced intermediate.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: October 28, 2014
    Assignee: F.I.S. Fabbrica Italiana Sintetiei S.p.A.
    Inventors: Andrea Castellin, Clark Ferrari, Marco Galvagni
  • Co-crystal intermediates of rosuvastatin and methods of using same
    Patent number: 8815862
    Abstract: Methods for the preparation of Rosuvastatin by co-crystals of Rosuvastatin or intermediates are provided. Also provided are co-crystals, pharmaceutical compositions which include such co-crystals and methods for treating conditions associated with hypercholesterolemia by administering such compositions.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: August 26, 2014
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Clark Ferrari, Andrea Castellin, Marco Galvagni, Nicolas Tesson, Jordi De Mier, Llorenç Rafecas
  • VERY EFFICIENT PROCESS FOR PREPARING AN INTERMEDIATE OF ETORICOXIB
    Publication number: 20140206882
    Abstract: The present invention relates to an efficient process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. Water is employed as reaction medium.
    Type: Application
    Filed: June 21, 2013
    Publication date: July 24, 2014
    Inventors: Paolo Stabile, Marco Galvagni
  • Very efficient process for preparing an intermediate of etoricoxib
    Patent number: 8765962
    Abstract: The present invention relates to an efficient process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. Water is employed as reaction medium.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: July 1, 2014
    Assignee: F.I.S.—Fabrica Italiana Sintetici S.p.A.
    Inventors: Paolo Stabile, Marco Galvagni
  • Synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine
    Patent number: 8680276
    Abstract: The present invention relates to the stereoselective synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine, as well as the conversion thereof, to give Moxifloxacin. Particularly, the present invention relates to a method for the synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) comprising: (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-2,3-dicarboxylate racemate of formula (II) to give, following isolation, the intermediate dialkyl-(2S,3R)-1-alkylcarbonyl-piperidine-2,3-dicarboxylate of formula (III) in which AIk is a straight or branched C1-C5 alkyl group; (b) the conversion of the intermediate (III) to (4aR,7aS)-1-alkylcarbonylhexahydrofuro[3,4-b]pyridine-5,7-dione of formula (IV) in which AIk has the meanings set forth above; (c) the conversion of the intermediate (IV) to (4aS,7as)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) with an optical purity above 99%.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: March 25, 2014
    Inventors: Riccardo Motterle, Giancarlo Arvotti, Elisabetta Bergantino, Andrea Castellin, Stefano Fogal, Marco Galvagni
  • PROCESS FOR THE PREPARATION OF OLOPATADINE
    Publication number: 20140024704
    Abstract: A process for the preparation of olopatadine hydrochloride starting from an advanced intermediate.
    Type: Application
    Filed: July 12, 2013
    Publication date: January 23, 2014
    Inventors: Andrea Castellin, Clark Ferrari, Marco Galvagni
  • Process for the preparation of efavirenz
    Patent number: 8420808
    Abstract: The present invention is directed to a process for the preparation of Efavirenz, (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one, of formula (I) comprising reacting the intermediate of formula (II) [0045] as a free base or a salt thereof, with diphosgene (TCMCF, trichlormethylchloroformate) Cl3CO—COCl in an organic solvent or in a biphasic medium comprised of an organic solvent and water, preferably but not mandatorily in the presence of a weak base in an amount sufficient to neutralise the reaction mixture or in an up to 30% molar excess of such amount.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: April 16, 2013
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Alessandro Leganza, Marco Galvagni
  • Process for the synthesis of quetiapine
    Patent number: 8389716
    Abstract: The present invention relates to a process for the synthesis of quetiapine. In particular, a process is provided for the synthesis of quetiapine of formula (A) comprising reacting dibenzo[b,f][1,4]thiazepin-11(10H)-one, intermediate (I) with phosphorous oxychloride to give 11-chlorodibenzo[b,f][1,4]thiazepine, intermediate (II) wherein the said reaction of intermediate (I) to intermediate (II) is performed in an organic solvent in the presence of a mixture of an organic base together with an inorganic base.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: March 5, 2013
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Siro Serafini, Filippo Tomasi, Marco Galvagni
  • IMATINIB MESYLATE PREPARATION PROCEDURE
    Publication number: 20130040958
    Abstract: Methods for making Imatinib mesylate of formula (I): having low levels of organic solvent are provided. Also provided are alpha and beta forms of Imatinib mesylate and methods for treating conditions such as chronic myelogenous leukaemia by administering same.
    Type: Application
    Filed: July 11, 2012
    Publication date: February 14, 2013
    Applicant: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Ennio GRENDELE, Marco GALVAGNI
  • PROCESS FOR THE PREPARATION OF EFAVIRENZ
    Publication number: 20110196151
    Abstract: The present invention is directed to a process for the preparation of Efavirenz, (4S)-6-chloro-4-(cyclopropy-lethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one, of formula (I) comprising reacting the intermediate of formula (II) [0045] as a free base or a salt thereof, with diphosgene (TCMCF, trichlormethylchloroformate) Cl3CO—COCl in an organic solvent or in a biphasic medium comprised of an organic solvent and water, preferably but not mandatorily in the presence of a weak base in an amount sufficient to neutralise the reaction mixture or in an up to 30% molar excess of such amount.
    Type: Application
    Filed: January 30, 2009
    Publication date: August 11, 2011
    Inventors: Alessandro Leganza, Marco Galvagni
  • SYNTHESIS OF (4aS,7aS)-OCTAHYDRO-1H-PYRROLO[3,4-b]PYRIDINE
    Publication number: 20110137036
    Abstract: The present invention relates to the stereoselective synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine, as well as the conversion thereof, to give Moxifloxacin. Particularly, the present invention relates to a method for the synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) comprising: (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-2,3-dicarboxylate racemate of formula (II) to give, following isolation, the intermediate dialkyl-(2S,3R)-1-alkylcarbonyl-piperidine-2,3-dicarboxylate of formula (III) in which AIk is a straight or branched C1-C5 alkyl group; (b) the conversion of the intermediate (III) to (4aR,7aS)-1-alkylcarbonylhexahydrofuro[3,4-b]pyridine-5,7-dione of formula (IV) in which AIk has the meanings set forth above; (c) the conversion of the intermediate (IV) to (4aS,7as)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) with an optical purity above 99%.
    Type: Application
    Filed: March 4, 2010
    Publication date: June 9, 2011
    Inventors: Riccardo Motterle, Giancarlo Arvotti, Elisabetta Bergantino, Andrea Castellin, Stefano Fogal, Marco Galvagni
  • PROCESS FOR THE SYNTHESIS OF QUETIAPINE
    Publication number: 20110118460
    Abstract: The present invention relates to a process for the synthesis of quetiapine. In particular, a process is provided for the synthesis of quetiapine of formula (A) comprising reacting dibenzo[b,f][1,4]thiazepin-11(10H)-one, intermediate (I) with phosphorous oxychloride to give 11-chlorodibenzo[b,f][1,4]thiazepine, intermediate (II) wherein the said reaction of intermediate (I) to intermediate (II) is performed in an organic solvent in the presence of a mixture of an organic base together with an inorganic base.
    Type: Application
    Filed: January 30, 2009
    Publication date: May 19, 2011
    Inventors: Siro Serafini, Filippo Tomasi, Marco Galvagni
  • PROCESS FOR THE PREPARATION OF OLOPATADINE
    Publication number: 20110065936
    Abstract: The present invention relates to a novel process for the preparation of olopatadine hydrochloride starting from an advanced intermediate.
    Type: Application
    Filed: March 23, 2010
    Publication date: March 17, 2011
    Inventors: Andrea Castellin, Clark Ferrari, Marco Galvagni