Abstract: A cooling apparatus having a compartment for storing products to be cooled and one or more tubes and/or wires connected to the compartment. A connecting element secures the tubes/wires to a compartment wall. The connecting element has a base portion configured to connect to the compartment wall and a supporting portion for supporting the tubes/wires. The supporting portion has first and second arms protruding from the base portion and defining a seat configured to receive the tubes/wires. The supporting portion has at least one elastic traverse member protruding from the first arm and/or the second arm towards the receiving seat. The elastic traverse member is configured to contact the tubes/wires that are inserted into the seat and secure the tubes/wires into the seat.

Abstract: A method for assembling a cooling apparatus having a cabinet which houses an inner casing defining at least one compartment for the storage of products to be cooled and one or more objects configured to be connected to the inner casing. The method includes: providing the inner casing; automatically univocally identifying the model of the inner casing among various known inner casing models by using a detecting device and performing a step of connecting the one or more objects to the inner casing based on the model of inner casing identified in the identifying step.

Abstract: A cooling apparatus having a compartment for storing products to be cooled and one or more tubes and/or wires connected to the compartment. A connecting element secures the tubes/wires to a compartment wall. The connecting element has a base portion configured to connect to the compartment wall and a supporting portion for supporting the tubes/wires. The supporting portion has first and second arms protruding from the base portion and defining a seat configured to receive the tubes/wires. The supporting portion has at least one elastic traverse member protruding from the first arm and/or the second arm towards the receiving seat. The elastic traverse member is configured to contact the tubes/wires that are inserted into the seat and secure the tubes/wires into the seat.

Abstract: A method for assembling a cooling apparatus having a cabinet which houses an inner casing defining at least one compartment for the storage of products to be cooled and one or more objects configured to be connected to the inner casing. The method includes: providing the inner casing; automatically univocally identifying the model of the inner casing among various known inner casing models by using a detecting device and performing a step of connecting the one or more objects to the inner casing based on the model of inner casing identified in the identifying step.

Abstract: A coprecipitate of protein or polypeptide and stabiliser obtained by a process for the co-precipitation of a substance with a stabiliser therefor, by a gas anti solvent process comprising introducing into a particle formation vessel a supercritical fluid pure or mixed with a modifier; and a solution comprising said substance and said stabiliser dissolved in a solvent; so as said solvent is extracted from the solution by said supercritical fluid and co-precipitation of the substance and stabiliser occurs. The process may be carried out using an apparatus comprising a particle formation vessel and a nozzle having a central orifice serving to introduce a solution of the substance and a plurality of outer orifices serving to carry a flow of supercritical fluid into the particle formation vessel, such that the solvent is extracted from the solution by the supercritical fluid and precipitation of micron sized particles of the substance/stabiliser occurs.

Abstract: A process for the co-precipitation of a substance with a stabilizer therefor, by a gas anti solvent process comprising introducing into a particle formation vessel a supercritical fluid pure or mixed with a modifier; and a solution comprising said substance and said stabilizer dissolved in a solvent; so as said solvent is extracted from the solution by said supercritical fluid and co-precipitation of the substance and stabilizer occurs. The process may be carried out using an apparatus, for example, shown in FIG. 1, comprising a particle formation vessel (22) and a nozzle (27) having a central orifice (39) serving to introduce a solution of the substance and a plurality of outer orifices (41) serving to carry a flow of supercritical fluid into the particle formation vessel (22), such that the solvent is extracted from the solution by the supercritical fluid and precipitation of micron sized particles of the substance/stabilizer occurs.

Abstract: A process for the sterilization of water insoluble solid medicinal substances is described. The process provides the sterilization of drug substances, which are suitable for pulmonary administration. In particular, the process is used in industrial plants for the production of formulations of sterile glucocorticoids for inhalation delivery, so as to avoid any modifications in particle size distribution and in the impurities profile of the drug. the process is carried out by heating a mixture of micronized glucocorticoid and purified water only, preferably at a temperature of about 120° C. for 20 minutes. The process is particularly efficient and economic for the steam sterilization of beclomethasone dipropionate in formulations for pulmonary delivery.

Abstract: Pharmaceutical compositions are described, containing an alkylammonium salt of a 2-arylpropionic acid, which are suitable for parenteral administration and do not generate pain upon injection. The compositions contain preferably ketoprofen, ibuprofen, naproxen or tiaprofenic acid in aqueous solution at pH in the range between 8 and 9. The alkylammonium salt is preferably a L-lysine salt. Compositions at pH=8,5 have shown to cause less pain upon injection than other known compositions.

Abstract: A process for the co-precipitation of a substance with a stabiliser therefor, by a gas anti solvent process compris- ing introducing into a particle formation vessel a supercritical fluid pure or mixed with a modifier, and a solution comprising said substance and said stabiliser dissolved in a solvent; so as said solvent is extracted from the solution by said supercritical fluid and co-precipitation of the substance and stabiliser occurs. The process may be carried out using an apparatus comprising a particle formation vessel (22) and a nozzle (27) having a central orifice (39) serving to introduce a solution of the substance and a plurality of outer orifices (41) serving to carry a flow of supercritical fluid into the particle formation vessel (22), such that the solvent is extracted from the solution by the supercritical fluid and precipitation of micron sized particles of the substance/stabilizer occurs.

Abstract: A pharmaceutical composition for parenteral administration having anti-inflammatory and analgesic properties is disclosed which contain, as the active principle, alkylammonium salts of 2-arylpropionic acids.

Abstract: The present invention relates to a topical formulation of gel-like consistency, but nebulizable by a mechanical pump, containing colloidal silices as gelifying agent.