Abstract: A process for reducing the particle size of an active pharmaceutical ingredient (API) while maintaining its polymorphic form, comprises the step of processing the active pharmaceutical ingredient by cavitation at elevated pressure. The process preferably comprises the step of isolating the processed active ingredient in the form of powder, wherein the isolation step comprises filtration or spray drying. Particles produced by the process of the invention typically have a span value of less than 2.5.

Abstract: A process for reducing the particle size of an active pharmaceutical ingredient (API) while maintaining its polymorphic form, comprises the step of processing the active pharmaceutical ingredient by cavitation at elevated pressure. The process preferably comprises the step of isolating the processed active ingredient in the form of powder, wherein the isolation step comprises filtration or spray drying. Particles produced by the process of the invention typically have a span value of less than 2.5.

Abstract: The invention relates to a folding tiller for boats. The inventive tiller comprises a central fixed part and two essentially-symetrical, opposing lateral segments which are articulated to the central part by means of respective hinges which are provided on two diametrically-opposed spokes of the tiller. According to the invention, the two lateral segments are folded down and stacked on top of the fixed part, in order to pass from an open extended position to a folded or retracted position. Moreover, respective longitudinally-opposing spoke segments are held in position by means of locking elements, at least while the tiller is to be maintained in the deployed configuration.