Abstract: The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.

Abstract: A closure element for closing a container, comprises an inner cap member to be coupled with a mouth of the container; an outer cap member rotatably coupled to the inner cap member, and a transponder housed between the inner cap member and the outer cap member. the transponder comprises a chip, an antenna, and a control loop. The chip is attached to one of a top wall of the inner cap member and a top wall of the outer cap member and at least a portion of the control loop is attached to the other of a top wall of the inner cap member and a top wall of the outer cap member, in such a way that a relative rotation of outer cap member and the inner cap member determines a torsion or shear force to act on the control loop to break it.

Abstract: A closure element for closing a container comprises an inner cap member coupled with a mouth of the container, an outer cap member movably coupled to the inner cap member, and a transponder having a chip and an antenna housed between the inner and outer cap members. The closure element further comprises two first capacitor plates connected with the chip, which are attached to one of a top wall of the inner cap member and a top wall of the outer cap member, and a second capacitor plate attached to the other of the top wall of the inner cap member and the top wall of the outer cap member, such that a relative movement of the outer cap member and the inner cap member switches the closure element between a first configuration and a second configuration having a different capacitance between the first and second capacitor plates.

Abstract: A closure element for closing a container, comprises an inner cap member to be coupled with a mouth of the container; an outer cap member rotatably coupled to the inner cap member, and a transponder housed between the inner cap member and the outer cap member. the transponder comprises a chip, an antenna, and a control loop. The chip is attached to one of a top wall of the inner cap member and a top wall of the outer cap member and at least a portion of the control loop is attached to the other of a top wall of the inner cap member and a top wall of the outer cap member, in such a way that a relative rotation of outer cap member and the inner cap member determines a torsion or shear force to act on the control loop to break it.

Abstract: A method of forming a closure member may include: providing a support member with an outer support surface; providing a member including a first member made of electrically conductive material, wherein the first member includes a first tubular sleeve extending along a longitudinal direction between a first top end and a first bottom end; positioning the member on the support member; applying a magnetic field on the member to deform at least a portion of the first tubular sleeve around the support member to form the closure member; and/or removing the formed closure member from the support member for subsequently fitting the formed closure member on a neck of a container or a closure body.

Abstract: A device for electromagnetic forming of components having a cavity may include: a core extending along a central axis and configured to be fitted into the cavity to carry out a forming operation on a component; wherein the core may be configured to be pulled out of the cavity after the forming operation, wherein the core may include a plurality of segments in parallel arrangement, wherein the segments may be made of non-conductive material, and wherein the segments may be configured to alternate between a machining configuration, in which the segments are locked together to prepare the core for a machining operation, and an extraction configuration, in which the segments mutually slide to reduce a diameter of the core and to remove the core from the cavity; and drive means for moving the segments, wherein the drive means is configured to alternate the segments between the machining and extraction configurations.

Abstract: The object of the present invention is a urinal apparatus fitted, in particular, with a special connection to which a duct is connected in order to extract the aerosol generated during its use, by means of an electric exhaust unit that expels the aerosol outside the bathroom, thus preventing it from being diffused inside the room.

Abstract: The subject of the present invention is a specially shaped toilet which prevents the diffusion of contaminated “aerosol” into the environment by sucking it directly from the toilet basin by means of an electric aspirator placed inside the toilet itself, and expelling it into the sewer pipe through specially fitted ducts.

Abstract: The present invention relates to a recognition system for recognizing containers to be filled with a given type of product, wherein the containers are equipped with a device for closing and opening the mouth through which the product to be introduced into the container is designed to pass. The closing and opening device is equipped with NFC electronic identification means. A corresponding reading and writing device for reading and writing said NFC electronic identification means is provided in the station for filling of the container and, in view of accommodating the container and the device for closing and opening its mouth, such station is conformed with at least the area configured to receive the device for closing and opening the mouth having a three-dimensional shape that mates the three-dimensional shape that the closing and opening device assumes when it is open to allow the container to be filled and/or emptied through the mouth.

Abstract: A device for forming components having a cavity comprises a core extending along a center axis and configured to fit into the cavity to machine the component with a forming process, the core is configured to be pulled out of the cavity after machining; the core comprises segments in mutually parallel arrangement, which are adapted to be alternated between a machining configuration and an extraction configuration, the segments are locked together in the machining configuration to prepare the core to machining, the segments are able to slide relative to each other in the extraction configuration, to reduce the diameter of the core and pull it out of the cavity; the device further comprises drive means of the segments to move them at least from the machining configuration to the extraction configuration.

Abstract: A tamper-evident closure includes a cap having a plug, a skirt, and a locking member. The cap and skirt have seats in which a first portion and a second portion of the locking member are arranged. Upon first opening, as the cap moves longitudinally away from the skirt, the lower edge of the cap passes over the first portion longitudinally so that, upon reclosing the tamper-evident closure, the first portion positions in an obstructive manner between the lower edge of the cap and an upper edge of the skirt.

Abstract: The invention provides a closure member (10, 110) for covering and/or closing a container (100, 200), in particular a bottle, the closure member (10, 110) comprising: a shell element (13, 113) comprising an opening (13d, 113d), the shell element (13, 113) being at least partially made of a conductive material, and a transponder (20, 120) comprising an antenna, the antenna being arranged at the opening (13d, 113d).

Abstract: The present invention relates to a recognition system for recognizing containers to be filled with a given type of product, wherein the containers are equipped with a device for closing and opening the mouth through which the product to be introduced into the container is designed to pass. The closing and opening device is equipped with NFC electronic identification means. A corresponding reading and writing device for reading and writing said NFC electronic identification means is provided in the station for filling of the container and, in view of accommodating the container and the device for closing and opening its mouth, such station is conformed with at least the area configured to receive the device for closing and opening the mouth having a three-dimensional shape that mates the three-dimensional shape that the closing and opening device assumes when it is open to allow the container to be filled and/or emptied through the mouth.

Abstract: A system is disclosed comprising a near field communication tag that is transformable from a first state to a second state. The system also comprises a server program stored on a non-transitory storage medium that, when executed by a server apparatus, receives a first tag report from a user device in response to the tag being tapped while being in the first state, sends a first response to the user device or to another user device in response to the first tag report being received, receives a second tag report from the user device in response to the tag being tapped while being in the second state, and sends a second response to the user device or to another user device in response to the second tag report being received.

Abstract: The invention provides a closure member (10, 110) for covering and/or closing a container (100, 200), in particular a bottle, the closure member (10, 110) comprising: a shell element (13, 113) comprising an opening (13d, 113d), the shell element (13, 113) being at least partially made of a conductive material, and a transponder (20, 120) comprising an antenna, the antenna being arranged at the opening (13d, 113d).

Abstract: A system is disclosed comprising a near field communication tag that is transformable from a first state to a second state. The system also comprises a server program stored on a non-transitory storage medium that, when executed by a server apparatus, receives a first tag report from a user device in response to the tag being tapped while being in the first state, sends a first response to the user device or to another user device in response to the first tag report being received, receives a second tag report from the user device in response to the tag being tapped while being in the second state, and sends a second response to the user device or to another user device in response to the second tag report being received.

Abstract: An assembly includes a container with a neck and a tamper-evident closure coupled to the container. The neck has a projection with a groove and a ramp. The tamper-evident closure includes a skirt with two portions engaged with the groove and the ramp. The skirt may be rotated relative to the neck to enlarge a diameter of the skirt and disengage the skirt from the neck.

Abstract: A tamper evident closure comprises a cap having a plug, a skirt and a locking member. The cap and the skirt have seats in which a first portion and a second portion of the locking member are arranged. Upon first opening, as the cap moves longitudinally away from the skirt, the lower edge of the cap passes over the first portion longitudinally so that, upon reclosing the closure, the first portion positions in an obstructive manner between the lower edge of the cap and the upper edge of the skirt.

Abstract: The present invention relates to a closure including a first stationary part and a second removable part. The second part includes a storage chamber and a dispensing opening. The first part includes a closing member and at least one passage opening. Upon first opening, the second part moves relative to the first part from a first configuration to a second configuration to cause the dispensing opening to disengage from the closing member and allow the product in the storage chamber to flow out into the container. In the first configuration, the first part engages the second part to form a first sealing portion, a second sealing portion, and a safety chamber arranged between the first sealing portion and the second sealing portion.

Abstract: A system is disclosed comprising a near field communication tag that is transformable from a first state to a second state. The system also comprises a server program stored on a non-transitory storage medium that, when executed by a server apparatus, receives a first tag report from a user device in response to the tag being tapped while being in the first state, sends a first response to the user device or to another user device in response to the first tag report being received, receives a second tag report from the user device in response to the tag being tapped while being in the second state, and sends a second response to the user device or to another user device in response to the second tag report being received.