Abstract: A method is provided for introducing a liquid into a depression of a sample holding plate by way of a controllable dispensing apparatus. The process of the introduction of the liquid is divided into the introduction of a first liquid volume and the introduction of a second liquid volume. A dispensing apparatus is also provided for introducing a liquid into a depression of a sample holding plate. The dispensing apparatus includes a control device that controls an actuator such that a first liquid volume and a second liquid volume are discharged out of an opening of a dispensing head.

Abstract: A device and method for producing a “biochip base module” for detecting biochemical reactions for the study of enzymatic reactions, nucleic acid hybridizations, protein-protein interactions and other binding reactions in the field of genome, proteome, or active-agent research. A flat macroporous support material having a multiplicity of 500 nm to 100 ?m diameter pores distributed over at least one surface region and extending from one surface through to the opposite surface of the support material. The device has two or more regions having pores with SiO2 pore walls. These regions are each surrounded by a frame or box of walls with a silicon core arranged parallel to the longitudinal axes of the pores and is open towards the surfaces. The silicon core merges into silicon dioxide over the cross section towards the outer side of the walls forming the frame, and each individual frame is spatially isolated from the frames surrounding it.

Abstract: A method for carrying out an amplification of nucleic acids in pores of a two-dimensionally designed macroporous support material according to one embodiment includes the step of providing a predetermined part of a reaction mixture necessary for the amplification of a nucleic acid in pores of the support material. A device for carrying out the amplification of nucleic acids according to one embodiment includes a two-dimensionally designed macroporous support material having a multiplicity of pores, wherein a predetermined part of a reaction mixture for carrying out an amplification of nucleic acids is provided in the pores.

Abstract: Method and apparatus for detecting chemical and/or biochemical reactions and/or bindings. A two-dimensional support structure which has, distributed over at least one surface region, a multiplicity of pores which extend continuously from one surface of the support structure to the opposite surface, is provided wherein the pores are bounded by pore boundary areas of pore walls formed in the support structure, and the pore walls have a refractive index npore wall at a wavelength ?. A liquid is introduced into at least one of the pores of the support structure, where the refractive index nliquid of the liquid at the wavelength ? is 0.90×npore wall>nliquid?1.10×npore wall. Light is coupling out of a substance to be investigated from the at least one pore, and the light of the substance to be investigated is detected.