Abstract: Described herein is a method of isolating a T cell that expresses a T cell receptor capable of binding specifically to an antigen presented by a cancer cell in association with an MR1 molecule. The method comprises the steps of (a) providing a preparation of T cells, (b) contacting the preparation with cancer cells expressing MR1 protein; (c) isolating a T cell that is specifically reactive to said cancer cells. The invention further relates to a method of preparing a T cell preparation expressing select MR1 recognizing T cell receptors from transgene expression vectors, the use of such T cell preparations in treatment of cancer, and to collections of MR1 reactive T cell receptor encoding nucleic acids and cells.

Abstract: The invention relates to a method of isolating a T cell that expresses a T cell receptor capable of binding specifically to an antigen presented by a cancer cell in association with an MR1 molecule. The method comprises the steps of (a) providing a preparation of T cells, (b) contacting the preparation with cancer cells expressing MR1 protein; (c) isolating a T cell that is specifically reactive to said cancer cells. The invention further relates to a method of preparing a T cell preparation expressing select MR1 recognizing T cell receptors from transgene expression vectors, the use of such T cell preparations in treatment of cancer, and to collections of MR1 reactive T cell receptor encoding nucleic acids and cells.

Abstract: The invention relates to a method of isolating a T cell that expresses a T cell receptor capable of binding specifically to an antigen presented by a cancer cell in association with an MR1 molecule. The method comprises the steps of (a) providing a preparation of T cells, (b) contacting the preparation with cancer cells expressing MR1 protein; (c) isolating a T cell that is specifically reactive to said cancer cells. The invention further relates to a method of preparing a T cell preparation expressing select MR1 recognizing T cell receptors from transgene expression vectors, the use of such T cell preparations in treatment of cancer, and to collections of MR1 reactive T cell receptor encoding nucleic acids and cells.

Abstract: A process and a drum for looping annular anchoring structures in a process for building tyres for vehicle wheels includes: depositing a loop on a drum including a radially expandable/contractible intermediate annular portion and, in a position axially adjacent to the opposite axial ends of the intermediate annular portion, a pair of radially expandable/contractible lateral annular portions; associating an annular anchoring structure with a radially outer annular surface portion of the loop defined at the intermediate annular portion; and turning up each of opposite end edges of the loop on the annular anchoring structure through the lateral annular portions as a result of a thrusting stress imparted by a respective lateral annular portion of the pair of lateral annular portions because of a synchronous radial movement and a synchronous axial displacement of a respective plurality of circumferentially adjacent first angular sectors.

Abstract: A process and a drum for looping annular anchoring structures in a process for building tyres for vehicle wheels includes: depositing a loop on a drum including a radially expandable/contractible intermediate annular portion and, in a position axially adjacent to the opposite axial ends of the intermediate annular portion, a pair of radially expandable/contractible lateral annular portions; associating an annular anchoring structure with a radially outer annular surface portion of the loop defined at the intermediate annular portion; and turning up each of opposite end edges of the loop on the annular anchoring structure through the lateral annular portions as a result of a thrusting stress imparted by a respective lateral annular portion of the pair of lateral annular portions because of a synchronous radial movement and a synchronous axial displacement of a respective plurality of circumferentially adjacent first angular sectors.

Abstract: A process and a drum for looping annular anchoring structures in a process for building tyres for vehicle wheels includes: depositing a loop on a drum including a radially expandable/contractible intermediate annular portion and, in a position axially adjacent to the opposite axial ends of the intermediate annular portion, a pair of radially expandable/contractible lateral annular portions; associating an annular anchoring structure with a radially outer annular surface portion of the loop defined at the intermediate annular portion; and turning up each of opposite end edges of the loop on the annular anchoring structure through the lateral annular portions as a result of a thrusting stress imparted by a respective lateral annular portion of the pair of lateral annular portions because of a synchronous radial movement and a synchronous axial displacement of a respective plurality of circumferentially adjacent first angular sectors.

Abstract: The invention relates to a method of isolating a T cell that expresses a T cell receptor capable of binding specifically to an antigen presented by a cancer cell in association with an MR1 molecule. The method comprises the steps of (a) providing a preparation of T cells, (b) contacting the preparation with cancer cells expressing MR1 protein; (c) isolating a T cell that is specifically reactive to said cancer cells. The invention further relates to a method of preparing a T cell preparation expressing select MR1 recognizing T cell receptors from transgene expression vectors, the use of such T cell preparations in treatment of cancer, and to collections of MR1 reactive T cell receptor encoding nucleic acids and cells.

Abstract: An apparatus for looping anchoring annular structures of a tyre for vehicle wheels, includes at least three looping drums. Each looping drum has a longitudinal axis thereof, with respect to which it is radially expandable/contractible in a manner so as to turn up the loop around an anchoring annular structure. The apparatus also includes a loop deposit station, a loading station configured for loading the anchoring annular structures on the looping drum and an unloading station configured for unloading the looped anchoring annular structures from the looping drum. The loop deposit station, loading station and unloading station are angularly offset from each other. A turret transfer apparatus supports the looping drums in positions angularly offset with respect to each other and is configured for transferring the looping drums between the loop deposit station, the loading station and the unloading station rotating around a vertically-arranged transfer axis.

Abstract: A process and a drum for looping annular anchoring structures in a process for building tyres for vehicle wheels includes: depositing a loop on a drum including a radially expandable/contractible intermediate annular portion and, in a position axially adjacent to the opposite axial ends of said intermediate annular portion, a pair of radially expandable/contractible lateral annular portions; associating an annular anchoring structure with a radially outer annular surface portion of the loop defined at the intermediate annular portion; and turning up each of opposite end edges of the loop on the annular anchoring structure through the lateral annular portions as a result of a thrusting stress imparted by a respective lateral annular portion of said pair of lateral annular portions because of a synchronous radial movement and a synchronous axial displacement of a respective plurality of circumferentially adjacent first angular sectors.