Patents by Inventor Marco Macchia

Marco Macchia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDOLE DERIVATIVES INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH)
    Publication number: 20140343001
    Abstract: The present invention encompasses compounds having general formula (I) able to inhibit the lactate production (lactic acid) involved in the angiogenesis of tumoral tissues, in the glycolytic metabolic process of tumoral cells, of immune system cells in asthmatic diseases, in vascular cells in the pulmonary hypertension, in the treatment of chronic back pain or hyperoxaluria, and in the process by which the parasites protozoan causing malaria obtain most of the necessary energy.
    Type: Application
    Filed: December 19, 2012
    Publication date: November 20, 2014
    Applicant: Universita di Pisa
    Inventors: Filippo Minutolo, Marco Macchia, Carlotta Granchi, Valeria Di Bussolo, Gino Giannaccini, Antonio Lucacchini, Paul J. Hergenrother, Emilia C. Calvaresi
  • COMPOUNDS INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
    Publication number: 20120309794
    Abstract: The present invention concerns compounds, some of which are novel, and their pharmaceutical applications. The compounds of the invention inhibit the enzyme lactate dehydrogenase (LDH) involved both in the metabolic process of hypoxic tumour cells, and in the process used by parasitic protozoa that cause malaria to obtain most of the energy they need.
    Type: Application
    Filed: November 5, 2010
    Publication date: December 6, 2012
    Applicant: UNIVERSITÀ DI PISA
    Inventors: Filippo Minutolo, Marco Macchia, Carlotta Granchi, Sarabindu Roy, Gino Giannaccini, Antonio Lucacchini
  • Ceramide analogs, process for their preparation and their use as antitumor agents
    Patent number: 7214794
    Abstract: The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: May 8, 2007
    Assignee: Bracco S.p.A.
    Inventors: Bruno Macchia, Aldo Balsamo, Marco Macchia, Mario Del Tacca, Romano Danesi
  • Ceramide analogs, process for their preparation and their use as antitumor agents
    Patent number: 6956109
    Abstract: The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: October 18, 2005
    Assignee: Bracco S.p.A.
    Inventors: Bruno Macchia, Aldo Balsamo, Marco Macchia, Mario Del Tacca, Romano Danesi
  • Ceramide analogs, process for their preparation and their use as antitumor agents
    Publication number: 20050020533
    Abstract: The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors.
    Type: Application
    Filed: August 17, 2004
    Publication date: January 27, 2005
    Inventors: Bruno Macchia, Aldo Balsamo, Marco Macchia, Mario Del Tacca, Romano Danesi
  • Geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions
    Patent number: 6242433
    Abstract: The present invention relates to novel geranylgeranyl derivatives and the pharmaceutically acceptable salts thereof having antiproliferative activity in eukaryotic cells with respect to the inhibition of protein geranygeranylation. The invention also relates to the pharmaceutical compositions containing the novel derivatives and to the process of preparation thereof.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: June 5, 2001
    Assignee: Laboratori Baldacci SpA
    Inventors: Aldo Balsamo, Bruno Macchia, Marco Macchia, Massimo Baldacci, Romano Danesi, Mario Del Tacca