Patents by Inventor Marco Manoni

Marco Manoni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11028422
    Abstract: The present invention describes a process for preparing ultrapure (?95%) galacto-oligosaccharides (GOS), starting from GOS at lower purities by using sequential microbiological purifications involving Saccharomyces cerevisiae and Streptococcus thermophilus.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: June 8, 2021
    Assignee: Ritter Pharmaceuticals, Inc.
    Inventors: Silvia Giacomelli, Marco Manoni, Giovanni Cipolletti, Silvia Biagiolini, Luana Vagnoli, Jacopo Chini
  • Publication number: 20190136280
    Abstract: The present invention describes a process for preparing ultrapure (?95%) galacto-oligosaccharides (GOS), starting from GOS at lower purities by using sequential microbiological purifications involving Saccharomyces cerevisiae and Streptococcus thermophilus.
    Type: Application
    Filed: October 5, 2018
    Publication date: May 9, 2019
    Inventors: Silvia Giacomelli, Marco Manoni, Giovanni Cipolletti, Silvia Biagiolini, Luana Vagnoli, Jacopo Chini
  • Publication number: 20160108447
    Abstract: The present invention describes a process for preparing ultrapure (?95%) galacto-oligosaccharides (GOS), starting from GOS at lower purities by using sequential microbiological purifications involving Saccharomyces cerevisiae and Streptococcus thermophilus.
    Type: Application
    Filed: October 28, 2015
    Publication date: April 21, 2016
    Inventors: Silvia Giacomelli, Marco Manoni, Giovanni Cipolletti, Silvia Biagiolini, Luana Vagnoli, Jacopo Chini
  • Patent number: 9200303
    Abstract: The present invention describes a process for preparing ultrapure (?95%) galacto-oligosaccharides (GOS), starting from GOS at lower purities by using sequential microbiological purifications involving Saccharomyces cerevisiae and Streptococcus thermophilics.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: December 1, 2015
    Assignee: Ritter Pharmaceuticals, Inc.
    Inventors: Silvia Giacomelli, Marco Manoni, Giovanni Cipolletti, Silvia Biagiolini, Luana Vagnoli, Jacopo Chini
  • Patent number: 9034844
    Abstract: The present invention relates to a process of synthesis of ?-sialyl oligosaccharides and in particular of 6?-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: May 19, 2015
    Assignee: INALCO S.P.A.
    Inventors: Giancarlo Tamerlani, Ilaria Lombardi, Debora Bartalucci, Andrea Danesi, Liana Salsini, Marco Manoni, Giovanni Cipolletti
  • Patent number: 8227595
    Abstract: The present invention relates to a process for industrially producing tagatose starting from galactose and provides for chemical isomerisation in presence of XAlO2 and XOH (with X=Na, K) and microbiological purification of the residual galactose.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: July 24, 2012
    Assignee: Inalco S.p.A.
    Inventors: Luana Vagnoli, Silvia Giacomelli, Marco Manoni, Giovanni Cipolletti
  • Publication number: 20120129802
    Abstract: The present invention describes a process for preparing ultrapure (?95%) galacto-oligosaccharides (GOS), starting from GOS at lower purities by using sequential microbiological purifications involving Saccharomyces cerevisiae and Streptococcus thermophilics.
    Type: Application
    Filed: August 6, 2010
    Publication date: May 24, 2012
    Inventors: Silvia Giacomelli, Marco Manoni, Giovanni Cipolletti, Silvia Biagiolini, Luana Vagnoli, Jacopo Chini
  • Publication number: 20120071441
    Abstract: The present invention relates to a process of synthesis of ?-sialyl oligosaccharides and in particular of 6?-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.
    Type: Application
    Filed: April 6, 2010
    Publication date: March 22, 2012
    Applicant: INALCO S.P.A.
    Inventors: Giancarlo Tamerlani, Ilaria Lombardi, Debora Bartalucci, Andrea Danesi, Liana Salsini, Marco Manoni, Giovanni Cipolletti
  • Publication number: 20110245488
    Abstract: The present invention relates to a process for the synthesis of L-fucosyl di- or oligosaccharides and their novel 2,3,4-tri-O-benzyl-fucosyl synthetic intermediates derivatives of easy crystallization. In particular the present invention relates to a process applicable to industrial scale for the synthesis of 2?O-fucosyl lactose.
    Type: Application
    Filed: December 18, 2009
    Publication date: October 6, 2011
    Applicant: INALCO S.P.A.
    Inventors: Liana Salsini, Marco Manoni, Giovanni Cipolletti
  • Publication number: 20100234587
    Abstract: The present invention relates to a process for industrially producing tagatose starting from galactose and provides for chemical isomerisation in presence of XAlO2 and XOH (with X=Na, K) and microbiological purification of the residual galactose.
    Type: Application
    Filed: March 9, 2010
    Publication date: September 16, 2010
    Inventors: Luana Vagnoli, Silvia Giacomelli, Marco Manoni, Giovanni Cipolletti
  • Patent number: 7687249
    Abstract: The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N— acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N-acetylheparosan polysaccharide prepared from natural or recombinant bacterial strain, preferably K5 E. coli, b) enzymatic epimerization with the glucuronyl C5-epimerase enzyme, c) partial O-sulphation followed by a partial O-desulphation, d) partial 6-O-sulphation, e) N-sulphation and an intermediate step of controlled depolimerization characterised by the fact that both O-sulphations (O-sulphation and 6O-sulphation) are partial. Furthermore the invention relates to the products obtained according to the process which show a ratio between the anti-Xa activity and anti-IIa activity equal to or higher than 1 and to compositions comprising said products in combination with suitable and pharmaceutically acceptable excipients and/or diluent.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: March 30, 2010
    Assignee: Inalco S.p.A.
    Inventors: Marco Manoni, Liana Salsini, Jacopo Chini, Giovanni Cipolletti
  • Publication number: 20070134373
    Abstract: A process for the preparation of high purity galactose is described, comprising the inoculum, of milk or milk serum not previously subjected to any type of preliminary treatment and/or purification procedure and not containing any bactericides or bacteriostats, with not modified micro-organisms commonly used in dairy industry.
    Type: Application
    Filed: October 28, 2004
    Publication date: June 14, 2007
    Inventors: Giovanni Cipoletti, Marco Manoni, Luana Vagnoli, Silvia Giacomelli, Silvia Biagiolini, Cristina Pratesi, Lucia Camici
  • Publication number: 20070042993
    Abstract: The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N-acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N-acetylheparosan polysaccharide prepared from natural or recombinant bacterial strain, preferably K5 E. coli, b) enzymatic epimerization with the glucuronyl C5-epimerase enzyme, c) partial O-sulphation followed by a partial O-desulphation, d) partial 6-0-sulphation, e) N-sulphation and an intermediate step of controlled depolimerization characterised by the fact that both 0-sulphations (0-sulphation and 60-sulphation) are partial. Furthermore the invention relates to the products obtained according to the process which show a ratio between the anti-Xa activity and anti-Ila activity equal to or higher than 1 and to compositions comprising said products in combination with suitable and pharmaceutically acceptable excipients and/or diluent.
    Type: Application
    Filed: July 7, 2004
    Publication date: February 22, 2007
    Inventors: Marco Manoni, Liana Salsini, Jacopo Chini, Giovanni Cipolletti
  • Publication number: 20050234014
    Abstract: The present invention refers to the preparation of O-sulphated, N-sulphatated or N-acetylated derivatives, both epimerised or non epimerised, of K5, K4, and optionally defructosilated K4 and K40 polysaccharides and to their use as antiinflammatory agents in chronic and acute inflammations.
    Type: Application
    Filed: May 17, 2005
    Publication date: October 20, 2005
    Inventors: Marco Manoni, Sandro Miletti, Giovanni Cipolletti, Rosanna Abbate, Maria Gori
  • Patent number: 6900311
    Abstract: The present invention refers to the preparation of O-sulphated, N-sulphatated or N-acetylated derivatives, both epimerised or non epimerised, of K5, K4, and optionally defructosilated K4 and K40 polysaccharides and to their use as antiinflammatory agents in chronic and acute inflammations.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: May 31, 2005
    Assignee: Inalco S.p.A.
    Inventors: Marco Manoni, Sandro Miletti, Giovanni Cipolletti, Rosanna Abbate, Maria Anna Gori
  • Publication number: 20030232785
    Abstract: The present invention refers to the preparation of O-sulphated, N-sulphatated or N-acetylated derivatives, both epimerised or non epimerised, of K5, K4, and optionally defructosilated K4 and K40 polysaccharides and to their use as antiinflammatory agents in chronic and acute inflammations.
    Type: Application
    Filed: January 21, 2003
    Publication date: December 18, 2003
    Inventors: Marco Manoni, Sandro Miletti, Giovanni Cipolletti, Rosanna Abbate, Maria Anna Gori