Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: A system (1) and method for the detection of wagon swing (6) are provided. Wagon swing is detected by specific sensors (5a, 5b, 5c, 5d) when a wagon (6) presents excessive swing when passing through a certain section of a railway track (2), in which such detection is made by measuring specific distances, advantageously disregarding an angle of attack of the wagon wheels (6) measured between an axis of such wheels and a horizontal plane on which railway tracks (2) are located.

Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: Integrated multiple actuator electro-hydraulic systems as well as their methods of use are described. Depending on the particular application, the integrated electro-hydraulic systems may exhibit different frequency responses and/or may be integrated into a single combined unit.

Abstract: The present invention relates to a method for optimization and recovery of second-generation sugar diluted stream, comprising pretreatment, enzymatic hydrolysis and mainly washing the residual solid from the enzymatic hydrolysis, which allows the increase of sugar recovery. The use of this sugar diluted stream is crucial for process integration, may have different possibilities of use, for example, can be applied in the mechanical refining step, microorganisms propagation, enzyme production, fermentation, enzymatic hydrolysis, including combination of uses.

Abstract: This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.

Abstract: A method of on-demand energy delivery to an active suspension system is disclosed. The suspension system includes an actuator body, a hydraulic pump, an electric motor, a plurality of sensors, an energy storage facility, and a controller. The method includes disposing an active suspension system in a vehicle between a wheel mount and a vehicle body, detecting a wheel event requiring control of the active suspension; and sourcing energy from the energy storage facility and delivering it to the electric motor in response to the wheel event.

Abstract: Methods for using SQL statements to access an application-server-managed database are disclosed herein. In some embodiments, a user sends, either directly or indirectly (i.e., remotely) a SQL statement from an ODBC application or server, respectively, to an application server that preprocesses SQL statements for accessing data from a centralized database. The application server may have a SQL endpoint, and access to the SQL endpoint may be determined by a user's logon credentials, a user's presentation of a SAML token, or a user's presentation of a valid certificate. The application server may then parse the SQL statement and determine the user's authorization to access certain objects in the centralized database based on a SQL handler design-time configuration. A result from the statement may be sent back to the user either directly or indirectly and exposed.

Abstract: A floating platform for high-power wind turbines, comprising a concrete substructure, said concrete substructure forming the base of the platform, which remains semi-submerged in the operating position, and consisting of a square lower slab on which a series of beams and five hollow reinforced concrete cylinders are constructed, distributed at the corners and the center of said lower slab; a metal superstructure supported on the concrete substructure and forming the base for connection with the wind turbine tower, said tower being coupled at the center thereof; and metal covers covering each of the cylinders, on which the metal superstructure is supported and to which vertical pillars are secured, linked together by beams, which join at the central pillar by an element whereon the base of the wind turbine tower is secured.

Abstract: A system for warning an open state of a two-part fan cowl of an aeronautical structure, wherein the system includes at least one device arranged between these two parts of the fan cowl and adapted to exert force spacing them apart from each other, thus leaving a predefined gap between them at their lower ends when that two-part fan cowl is in the open state.

Abstract: A dental imager includes an elongated handle with a rotatable head coupled to a distal end thereof and having a central platform with a plurality of arcuate scanning arms pivotally coupled thereto by a hinge. The arcuate scanning arms are of a shape and size for general deployment around a tooth and each include at least one scanner and a roller guide that comfortably rolls along the surface of the tooth or gums to bias the scanners a desired distance from the surface of the tooth, conducive for imaging thereof. In this respect, such a dental imager may be used in a process to scan and record the contours of an intraoral surface, the data of which may be used to create a digital three-dimensional surface impression printable by a 3D printer or the like.

Abstract: A system for warning an open state of a two-part fan cowl of an aeronautical structure, wherein the system includes at least one device arranged between these two parts of the fan cowl and adapted to exert force spacing them apart from each other, thus leaving a predefined gap between them at their lower ends when that two-part fan cowl is in the open state.

Abstract: A dental imager includes an elongated handle with a rotatable head coupled to a distal end thereof and having a central platform with a plurality of arcuate scanning arms pivotally coupled thereto by a hinge. The arcuate scanning arms are of a shape and size for general deployment around a tooth and each include at least one scanner and a roller guide that comfortably rolls along the surface of the tooth or gums to bias the scanners a desired distance from the surface of the tooth, conducive for imaging thereof. In this respect, such a dental imager may be used in a process to scan and record the contours of an intraoral surface, the data of which may be used to create a digital three-dimensional surface impression printable by a 3D printer or the like.

Abstract: The invention relates to an insert for an exhaust manifold of a heat exchanger device for a cooking appliance comprising a support for two or more pipe sockets having at least one expansion slit, a first cover for the at least one expansion slit on the support, an insulation comprising a support insulation on the first cover and a pipe socket insulation around at least a portion of the pipe socket, and a second cover at least on the pipe socket insulation. It further relates to an exhaust manifold with such an insert, a heat exchanger device with such an exhaust manifold, and a cooking appliance with such a heat exchanger device.

Abstract: A dental imager includes an elongated handle with a rotatable head coupled to a distal end thereof and having a central platform with a plurality of arcuate scanning arms pivotally coupled thereto by a hinge. The arcuate scanning arms are of a shape and size for general deployment around a tooth and each include at least one scanner and a roller guide that comfortably rolls along the surface of the tooth or gums to bias the scanners a desired distance from the surface of the tooth, conducive for imaging thereof. In this respect, such a dental imager may be used in a process to scan and record the contours of an intraoral surface, the data of which may be used to create a digital three-dimensional surface impression printable by a 3D printer or the like.

Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT), Animal African trypanosomiasis (AAT) and leishmaniasis, particularly visceral leishmaniasis (VL).

Abstract: The present invention refers to a vibration damping connector (100) for reducing vibrations between a vibration prone system and an optical imaging system, said vibration damping connector comprising a first part (1) adapted to be connected to said optical imaging system, a second part (2) adapted to be connected to said vibration prone system, and at least one first shock absorbing element (3), a portion of said first part (1) is arranged inside a portion of said second part (2) along a central axis (A) or a portion of said second part (2) is arranged inside a portion of said first part (1) along a central axis (A) and said at least one flexible shock absorbing element (3) is arranged between said first part (1) and said second part (2), said vibration damping connector (100) further comprises at least one fastening device (4) for fastening said first part (1) to said second part (2) and said fastening device (2) presses said first part(1) to said second part (2) via a second shock absorbing element (5).

Abstract: Open filtering equipment for a water treatment station, for open filters with a filter bed such as sand, coal, etc., comprising a plurality of support legs (10), a plurality of frames (20) supported on said support legs (10), each having at least one opening (22), said plurality of frames (20) being suitable to cover the bottom of a filter, and a plurality of filtering assemblies with a flat upper surface, each of them attachable on a frame (20) covering an opening (22) thereof, and each filter assembly comprising a filtering grid (32) for filtering the water from the filter bed by filtering.

Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT) and leishmaniasis, particularly visceral leishmaniasis (VL).

Abstract: The present invention refers to a vibration damping connector (100) for reducing vibrations between a vibration prone system and an optical imaging system, said vibration damping connector comprising a first part (1) adapted to be connected to said optical imaging system, a second part (2) adapted to be connected to said vibration prone system, and at least one first shock absorbing element (3), a portion of said first part (1) is arranged inside a portion of said second part (2) along a central axis (A) or a portion of said second part (2) is arranged inside a portion of said first part (1) along a central axis (A) and said at least one flexible shock absorbing element (3) is arranged between said first part (1) and said second part (2), said vibration damping connector (100) further comprises at least one fastening device (4) for fastening said first part (1) to said second part (2) and said fastening device (2) presses said first part(1) to said second part (2) via a second shock absorbing element (5).