Patents by Inventor Marco Molinari

Marco Molinari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of Melphalan
    Patent number: 11787761
    Abstract: The invention relates to a process for the preparation of Melphalan (4-[bis(2-5 chloroethyl)amino]-L-phenylalanine of formula (I) said process comprising the reaction of a 4-amino-L-phenylalanine protected at the carboxy and amino aminoacidic groups with an agent able to convert the aromatic amino group into a group of formula: —N(CH2CH2OS(O)nO—)2, wherein n is 1 or 2 followed by conversion of the ?N(CH2CH2OS(O)nO—)2 group into a —N(CH2CH2Cl)2 group. The invention also provides novel intermediates useful for the preparation of Melphalan.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: October 17, 2023
    Assignee: Indena S.P.A.
    Inventors: Pietro Allegrini, Andrea Bonetti, Marco Molinari, Andrea Gambini
  • PROCESS FOR THE SYNTHESIS OF MELPHALAN
    Publication number: 20230286901
    Abstract: The invention relates to a process for the preparation of Melphalan (4-[bis(2-chloroethyl)amino]-L-phenylalanine of formula (I) said process comprising the reaction of a 4-amino-L-phenylalanine protected at the carboxy and amino aminoacidic groups with an agent able to convert the aromatic amino group into a group of formula: —N(CH2CH2OS(O)nO?)2, wherein n is 1 or 2 followed by conversion of the —N(CH2CH2OS(O)nO?)2 group into a —N(CH2CH2Cl)2 group. The invention also provides novel intermediates useful for the preparation of Melphalan.
    Type: Application
    Filed: May 19, 2023
    Publication date: September 14, 2023
    Applicant: Indena S.P.A.
    Inventors: Pietro Allegrini, Andrea Bonetti, Marco Molinari, Andrea Gambini
  • A PROCESS FOR THE SYNTHESIS OF MELPHALAN
    Publication number: 20230094970
    Abstract: The invention relates to a process for the preparation of Melphalan (4-[bis(2-5 chloroethyl)amino]-L-phenylalanine of formula (I) said process comprising the reaction of a 4-amino-L-phenylalanine protected at the carboxy and amino aminoacidic groups with an agent able to convert the aromatic amino group into a group of formula: —N(CH2CH2OS(O)nO—)2, wherein n is 1 or 2 followed by conversion of the ?N(CH2CH2OS(O)nO—)2 group into a —N(CH2CH2Cl)2 group. The invention also provides novel intermediates useful for the preparation of Melphalan.
    Type: Application
    Filed: December 21, 2020
    Publication date: March 30, 2023
    Applicant: Indena S.P.A.
    Inventors: Pietro Allegrini, Andrea Bonetti, Marco Molinari, Andrea Gambini