Patents by Inventor Marco Rasponi

Marco Rasponi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microfluidic devices and related methods for generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs
    Patent number: 10961492
    Abstract: A microfluidic device for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs that includes a culture chamber may include: a confinement apparatus configured to define at least one compartment configured to contain a cellular matrix and at least one compartment configured to contain a culture medium, the confinement apparatus being hydrophobic and pervious to the culture medium; and/or at least one counter element. The confinement apparatus and at least one counter element may be reciprocally mobile between resting and compression positions of the cellular matrix. A method for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs at a microscale may include: controlled compression of a cellular matrix for a predetermined period of time. The cellular matrix may be delimited by a confinement apparatus that is pervious to a culture medium.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 30, 2021
    Assignees: POLITECNICO DI MILANO, FONDAZIONE CARIPLO
    Inventors: Alberto Redaelli, Marco Rasponi, Paola Occhetta
  • Methods, devices, and systems for microfluidic stress emulation
    Patent number: 10413901
    Abstract: Provided herein is technology relating to microfluidic devices and particularly, but not exclusively, to devices, methods, systems, and kits for imparting stresses on a fluid flowing through a microfluidic device that is designed to mimic a stress profile of a macrofluidic device or pathology.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: September 17, 2019
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, POLITECNICO DI MILANO
    Inventors: Marvin J. Slepian, Alberto C. Redaelli, Marco Rasponi, Danny Bluestein
  • MICROFLUIDIC DEVICES AND RELATED METHODS FOR GENERATION AND/OR CULTURE AND/OR MATURATION OF THREE-DIMENSIONAL CELLS AND/OR TISSUE CONSTRUCTS
    Publication number: 20180105782
    Abstract: A microfluidic device for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs that includes a culture chamber may include: a confinement apparatus configured to define at least one compartment configured to contain a cellular matrix and at least one compartment configured to contain a culture medium, the confinement apparatus being hydrophobic and pervious to the culture medium; and/or at least one counter element. The confinement apparatus and at least one counter element may be reciprocally mobile between resting and compression positions of the cellular matrix. A method for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs at a microscale may include: controlled compression of a cellular matrix for a predetermined period of time. The cellular matrix may be delimited by a confinement apparatus that is pervious to a culture medium.
    Type: Application
    Filed: April 28, 2016
    Publication date: April 19, 2018
    Inventors: Alberto REDAELLI, Marco RASPONI, Paola OCCHETTA
  • METHODS, DEVICES, AND SYSTEMS FOR MICROFLUIDIC STRESS EMULATION
    Publication number: 20170246632
    Abstract: Provided herein is technology relating to microfluidic devices and particularly, but not exclusively, to devices, methods, systems, and kits for imparting stresses on a fluid flowing through a microfluidic device that is designed to mimic a stress profile of a macrofluidic device or pathology.
    Type: Application
    Filed: August 28, 2015
    Publication date: August 31, 2017
    Inventors: Marvin J. Slepian, Alberto C. Redaelli, Marco Rasponi, Danny Bluestein