Patents by Inventor Marco Silvagni

Marco Silvagni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclic derivatives, process for their preparation and their use as kinase inhibitors
    Patent number: 8916577
    Abstract: New substituted tricyclic compounds of formula (I) are described, wherein R1, R2, X, Y, Z are herein defined, having protein kinase inhibiting activity. The invention includes methods to prepare the compounds of formula (I), pharmaceutical compositions containing them, and their use in therapy, in particular for the treatment of diseases caused by and/or associated with dysregulated activity of protein kinase.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: December 23, 2014
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Marina Caldarelli, Francesco Casuscelli, Daniele Donati, Danilo Mirizzi, Francesca Quartieri, Marco Silvagni
  • Pyrazolo-quinazolines
    Patent number: 8846701
    Abstract: The present invention relates to pyrazolo-quinazolines, characterized by an ortho-substituted-arylamino, heterocyclylamino- or C3-C7 cycloalkylamino residue at 8 position and an aryl, heterocyclyl or C3-C7 cycloalkyl as substituent of a carboxamide at 3 position of the molecule framework. The compounds of this invention modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1/TTK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: September 30, 2014
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Marina Caldarelli, Mauro Angiolini, Riccardo Colombo, Teresa Disingrini, Stefano Nuvoloni, Helena Posteri, Matteo Salsa, Marco Silvagni
  • TRICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20130302416
    Abstract: New substituted tricyclic compounds of formula (I) are described, wherein R1, R2, X, Y, Z are herein defined, having protein kinase inhibiting activity. The invention includes methods to prepare the compounds of formula (I), pharmaceutical compositions containing them, and their use in therapy, in particular for the treatment of diseases caused by and/or associated with dysregulated activity of protein kinase.
    Type: Application
    Filed: January 19, 2012
    Publication date: November 14, 2013
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Marina Caldarelli, Francesco Casuscelli, Daniele Donati, Danilo Mirizzi, Francesca Quartieri, Marco Silvagni
  • PYRAZOLO--QUINAZOLINES
    Publication number: 20110105542
    Abstract: The present invention relates to pyrazolo-quinazolines, characterized by an ortho-substituted-arylamino, heterocyclylamino- or C3-C7 cycloalkylamino residue at 8 position and an aryl, heterocyclyl or C3-C7 cycloalkyl as substituent of a carboxamide at 3 position of the molecula framework. The compounds of this invention modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1/TTK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: June 17, 2009
    Publication date: May 5, 2011
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Marina Caldareli, Mauro Angiolini, Riccardo Colombo, Teresa Disingrini, Stefano Nuvoloni, Helena Posteri, Matteo Salsa, Marco Silvagni
  • Process for obtaining compounds usable in the production of Cefotetan, and new compounds obtained thereby
    Patent number: 6583291
    Abstract: A safe and economical process for obtaining salts of 4-carboxy-3-hydroxy-5-mercapto-isothiazole. This process comprises refluxing a disodium or dipotassium salt of 3-hydroxy-5-mercapto-4-isothiazole carbonitrile in an aqueous solution of sodium or potassium hydroxide to produce the desired salt. The desired salt may be precipitated out of solution by adjusting the pH downward to a minimum value of about pH 8. Compounds produced by this process may be used for producing semi-synthetic cephalosporins.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: June 24, 2003
    Assignee: ACS Dobfar S.p.A.
    Inventors: Maurizio Zenoni, Alessandro Donadelli, Marco Silvagni
  • Process for obtaining compounds usable in the production of Cefotetan, and new compounds obtained thereby
    Publication number: 20020169327
    Abstract: A process for obtaining salts of 4-carboxy-3-hydroxy-5-mercapto-isothiazole which are compounds usable in the production of Cefotetan, and new compounds obtained thereby.
    Type: Application
    Filed: April 17, 2002
    Publication date: November 14, 2002
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Maurizio Zenoni, Alessandro Donadelli, Marco Silvagni