Patents by Inventor Marcos Da Silva Freire

Marcos Da Silva Freire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method, kit, plasmid and composition for inducing an immune response to dengue virus, on the basis of DNA and chimeric virus vaccines
    Patent number: 10357558
    Abstract: The present invention relates to a method for inducing an immune response to the dengue virus, on the basis of DNA and 17D chimeric virus vaccines in combined or co-administered immunisation. The scope of the present invention also includes DNA vaccines against the four serotypes of the dengue virus, produced by forming, from each viral serotype of the dengue virus (DENV1-4), various recombinant plasmids that contain the gene that codes for the E protein, or that contain only the sequence that corresponds to the domain III of this protein. The invention also provides a vaccine composition consisting of (a) DNA vaccines against the four serotypes of the dengue virus; (b) chimeric viruses comprising the modified yellow fever vaccination virus 17D; and (c) a pharmaceutically acceptable carrier, all of which are covered by the scope of the invention.
    Type: Grant
    Filed: August 1, 2010
    Date of Patent: July 23, 2019
    Assignee: Fundacao Oswaldo Cruz
    Inventors: Ada Maria de Barcelos Alves, Adriana de Souza Azevedo, Ricardo Galler, Marcos da Silva Freire
  • METHOD, KIT, PLASMID AND COMPOSITION FOR INDUCING AN IMMUNE RESPONSE TO DENGUE VIRUS, ON THE BASIS OF DNA AND CHIMERIC VIRUS VACCINES
    Publication number: 20120251570
    Abstract: The present invention relates to a method for inducing an immune response to the dengue virus, on the basis of DNA and 17D chimeric virus vaccines in combined or co-administered immunisation. The scope of the present invention also includes DNA vaccines against the four serotypes of the dengue virus, produced by forming, from each viral serotype of the dengue virus (DENV1-4), various recombinant plasmids that contain the gene that codes for the E protein, or that contain only the sequence that corresponds to the domain III of this protein. The invention also provides a vaccine composition consisting of (a) DNA vaccines against the four serotypes of the dengue virus; (b) chimeric viruses comprising the modified yellow fever vaccination virus 17D; and (c) a pharmaceutically acceptable carrier, all of which are covered by the scope of the invention.
    Type: Application
    Filed: August 1, 2010
    Publication date: October 4, 2012
    Applicant: Fundacao Oswaldo Cruz
    Inventors: Ada Maria de Barcelos Alves, Adriana de Souza Azevedo, Ricardo Galler, Marcos da Silva Freire
  • Use of flavivirus for the expression of protein epitopes and development of new live attenuated vaccine virus to immunize against flavivirus and other infectious agents
    Publication number: 20060159704
    Abstract: The present invention relates to a vaccine against infections caused by flavivirus. More particularly to the use of the YF vaccine virus (17D) to express at the level of its envelope, protein epitopes from other pathogens which will elicit a specific immune response to the parental pathogen.
    Type: Application
    Filed: August 17, 2005
    Publication date: July 20, 2006
    Applicant: Fundacao Oswaldo Cruz-FIOCRUZ
    Inventors: Mirna Bonaldo, Ricardo Galler, Marcos da Silva Freire, Richard Garrat
  • Use of flavivirus for the expression of protein epitopes and development of new live attenuated vaccine virus to immune against flavivirus and other infectious agents
    Publication number: 20030194801
    Abstract: The present invention relates to a vaccine against infections caused by flavivirus. More particularly to the use of the YF vaccine virus (17D) to express at the level of its envelope, protein epitopes from other pathogens which will elicit a specific immune response to the parental pathogen.
    Type: Application
    Filed: April 10, 2003
    Publication date: October 16, 2003
    Inventors: Mirna C. Bonaldo, Ricardo Galler, Marcos da Silva Freire, Richard C. Garrat
  • Vaccines against infections caused by YF virus; YF infectious cDNA, method for producing a recombinant YF virus from the YF infectious cDNA and plasmids to assemble the YF infectious cDNA
    Patent number: 6589522
    Abstract: The present invention is related to a vaccine composition for humans against YF infections consisting essencially of a recombinant YF virus, YFiv5.2/DD, which is regenerated from YF infectious cDNA. There is provided new plasmids, pYF 5′3′ IV/G1/2 and pYFM 5.2/T3/27, which together, have the complete sequence of said YF infectious cDNA. The method for producing recombinant YF virus and the Original, Primary and Secondary Seed Lots are other embodiments of the present invention.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: July 8, 2003
    Assignee: Fundacao Oswaldo Cruz-Fiocruz
    Inventors: Ricardo Galler, Marcos Da Silva Freire
  • Yellow fever infectious cDNA and plasmids
    Patent number: 6171854
    Abstract: The present invention is related to a vaccine composition for humans against YF infections consisting essentially of a recombinant YF virus, YFiv5.2/DD, which is regenerated from YF infectious cDNA. There are provided new plasmids, pYF 5′3′ IV/G1/2 and pYFM 5.2/T3/27, which together, have the complete sequence of said YF infectious cDNA. The method for producing recombinant YF virus and the Original, Primary and Secondary Seed Lots are other embodiments of the present invention.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: January 9, 2001
    Assignee: Fundaco Oswaldo Cruz-Fiocruz
    Inventors: Ricardo Galler, Marcos Da Silva Freire