Abstract: A device for monitoring the health state is made in a chip including a semiconductor die integrating an electric potential sensor and a cardiac parameter determination unit. The potential sensor is configured to detect potential variations on the body of a living being and associated with a heart rhythm and to generate a cardiac signal. The cardiac parameter determination unit is configured to receive the cardiac signal and determine cardiac parameters indicative of a health state. In particular, the cardiac parameter determination unit is configured to detect triggering events and to determine features of the cardiac signal in time windows defined by the triggering events. The die also integrates a decision unit, configured to receive the cardiac parameters and generate a health signal based on a comparison with threshold values. The cardiac parameters include heart rate and QRS-complex.

Abstract: Systems and methods for providing modular building unit or “pods” are provided. In various embodiments, site-specific conditions and risk factors are evaluated and identified. The conditions and risk factors are used to inform decisions and design requirements for one or more pods and to modify or reinforce a pod prior to installation if needed. Methods and systems of securing the pods are also provided.

Abstract: A gripping device (200) is proposed for gripping a sewing thread (415) in a bookbinding sewing machine (100). The gripping device (200) comprises a crochet (205) and a body (220) that are slidable reciprocally between an open condition, wherein a hook (215) of the crochet (205) hooks the sewing thread (415), and a closed condition, wherein the hook (215) blocks the sewing thread (415); the body (220) has one or more channels (270) crossing it for conveying a gas jet towards the hook (215). A bookbinding sewing machine (100) comprising one or more gripping devices (200) is also proposed. Moreover, a corresponding method for sewing signatures (115) into book blocks (155) is proposed.

Abstract: An improved methods and systems for detecting defect(s) on a mask are disclosed. An improved method comprises inspecting an exposed wafer after the wafer was exposed, by a lithography system using a mask, with a selected process condition that is determined based on a mask defect printability under the selected process condition; and identifying, based on the inspection, a wafer defect that is caused by a defect on the mask to enable identification of the defect on the mask.

Abstract: A splined shaft includes splines evenly distributed over the periphery, wherein the splines being spaced apart from each other. At least one portion of the splines are spaced apart by a modified pitch p with respect to the nominal pitch pn of the splines. The ratio of the absolute value of the difference between the modified pitch and the nominal pitch, to the nominal pitch, i.e. |pn?p|/pn, is different from zero, for example between 0.5 and 5%.

Abstract: The present invention concerns platelets transfected with exogenous genetic material and microparticles deriving from said transfected platelets having a high percentage of transfection and able to transport and to transfect acceptor cells with genetic material and then used for example in gene and cell therapy. The invention further concerns a method for the preparation of mature platelets transfected with exogenous genetic material and microparticles deriving from said transfected platelets and microparticles deriving from said transfected mature platelets which permits to obtain high percentages of transfection.

Abstract: The invention relates to a structural system (2) for the modular construction of shelves (2), comprising a set of elongate vertical supports (3), a set of frames (4) and a set of connectors (7). The vertical supports (3) each have at least one axially extending row of holes (31). The frames (4) each have four struts (42, 43), of which two are connected to one another via a mounting corner piece (41). The connectors (7) are each designed to be introduced into a hole (311) of one of the vertical supports (3) and secured to one of the mounting corner pieces (41) of one of the frames (4).

Abstract: A method for making a semiconductor memory device comprising a plurality of memory cells for storing one or more data values, the method comprising; exposing a pattern on a wafer for creating structures for a plurality of memory cells for the semiconductor memory device, wherein the pattern is exposed by means of one or more charged particle beams; and varying an exposure dose of the one or more charged particle beams during exposure of the pattern to generate a set of one or more non-common features in one or more structures of at least one of the memory cells, so that the structures of the at least one memory cell differ from the corresponding structures of other memory cells of the semiconductor memory device.

Abstract: An air conduit for a respiratory therapy device comprises a first end, a second end, and a tube portion, wherein the tube portion comprises a tube wall and an auxiliary structure, such as a rib. The air conduit may deliver a flow of air from a respiratory therapy device or a humidifier to a patient interface. The air conduit may comprise a plurality of auxiliary structures, some of which may consist of a polymeric material, and some of which may comprise a polymeric material and an electrical conductor. An auxiliary structure may be a helical rib extending across a length of the tube portion.

Abstract: Regulatory T cells (Treg cells), formerly known as suppressor T cells, are crucial for the maintenance of immunological tolerance. Their major role is to shut down T cell-mediated immunity toward the end of an immune reaction and to suppress auto-reactive T cells that escaped the process of negative selection in the thymus. Two major classes of CD4+ Treg cells have been described—naturally occurring Treg cells and adaptive Treg cells. Disclosed herein are methods for producing efficacious CAR Treg cells in a GMP-scalable system.

Abstract: A system for obtaining biomechanical parameters of ocular tissue includes an air-puff module to deliver an air-puff stimulus onto the ocular tissue, and an imaging device operatively coupled to the air-puff module. The air-puff module includes a transparent window at its front with a transparent through hole for delivering the air-puff stimulus. The hole is aligned with an imaging device optical axis, such that the air-puff stimulus delivered onto the ocular tissue can be centred on an apex of the ocular tissue and made collinear with the optical axis. The transparent window and through hole allow continuity of imaging of the ocular surface. The imaging device captures the 3D coordinates of points distributed on an ocular tissue surface in groups of simultaneous points. The system includes a component for selecting and changing location and distribution of captured points on the ocular tissue, and a processing component to process the points.

Abstract: The disclosure provides a computer device. The computer device includes a base, a host case, and a display support. The base includes an upper surface and includes a power module therein. The host case is detachably fixed to the base and electrically connected to the power module through the upper surface. One end of the display support is connected to the base, and the other end thereof includes a display connection structure.

Abstract: A gripping tool, which can be used by a manipulator device for picking-up and handling pieces, includes a plurality of gripping devices (50), distributed in groups, each group consisting of one or more gripping devices. The gripping devices (50) of each group of gripping devices are mounted on a same supporting body (P), which is made in one-piece by an additive manufacturing technology.

Abstract: A computer device and a host module thereof are provided. The host module includes a case, a motherboard, and a power supply unit. The case includes a first side plate, a second side plate, a front panel, a rear panel, and a separation structure. The rear panel is located on an opposite side of the front panel. The first side plate, the second side plate, the front panel, and the rear panel enclose an internal space. The separation structure is located in the internal space, extends from the first side plate to the second side plate, and divides the internal space into a first part and a second part. The second part is located under the first part. The motherboard is disposed in the first part. The power supply unit is disposed in the second part, and is electrically connected to the motherboard.

Abstract: A sample input interface for inputting samples into a detecting unit of an in-vitro diagnostic analyzer. The sample input interface comprises a sample input port comprising an outer input-port side configured for plugging-in an open end of a sample container and an inner input-port side, an aspiration needle comprising an upstream end and a downstream end, where the downstream end is fluidically connected or connectable to the detecting unit and where the upstream end is configured to alternately couple to the inner input-port side and to a fluid supply port. The outer input-port side is further configured to alternately couple to a fluid supply port while the upstream end of the aspiration needle is coupled to the inner input-port side in order to rinse the sample input port with fluid aspirated by the aspiration needle from a fluid supply unit via the sample input port.

Abstract: A method for operating a first vehicle (100) with a parking assistance system (110) is proposed, comprising: a) sensing an obstructing parked position (BP) of the first vehicle (100) by means of the parking assistance system (110), wherein the obstructing parked position (BP) is a parked position which adjoins a parking space (PP) occupied by a parked second vehicle (150), b) reception of a sensor signal, acquired by a sensor apparatus (120, 130) of the vehicle (100), by means of the parking assistance system (110), c) detecting a request to exit a parking space of the parked second vehicle (150) in accordance with the received sensor signal by means of the parking assistance system (110), and d) autonomously driving the first vehicle (100) from the obstructing parked position (BP) into a position which is different from the obstructing parked position (BP) in accordance with the detected request to exit a parking space by means of the parking assistance system (110).

Abstract: Methods for processing polyolefin recyclates including, but not limited to, polyethylene and polypropylene and compositions therefrom are provided. polyolefin recyclate feedstocks can be visbroken to improve processing characteristics and/or devolatilized to remove waste byproducts to produce processed polyolefin recyclates. Processed polyolefin recyclates are compounded with pre-consumer polyolefins to produce blend compositions having acceptable or even improved processing characteristics. Such pre-consumer polyolefins can also be visbroken to further tailor processing characteristics of such polymer blends. A combination of extruders and/or extruder zones can be used at the same or different locations for visbreaking and/or compounding of both polyolefin recyclate and/or pre-consumer polyolefins.

Abstract: Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

Abstract: An example temperature sensing device includes an air distribution inlet through which primary air is blown into via an environmental control system, a cabin air inlet through which secondary air enters from a passenger area of a fuselage and the cabin air inlet is coupled to the air distribution inlet through a duct and the secondary air is passively drawn into the cabin air inlet and to the duct due to a pressure difference present in the duct, and a temperature sensor coupled to the duct and positioned downstream of the cabin air inlet along an airflow path of the secondary air so as to be exposed to the secondary air drawn in through the cabin air inlet and flowing through the duct.

Abstract: In some embodiments, the invention relates to methods and reagents for the identification of compounds that traverse he cell membrane of an animal cell. In some embodiments, the invention provides additional methods for determining if a candidate compound that traverses an animal cell membrane is able to modulate an intracellular target, as well as reagents and kits for reagents and kits for performing the disclosed methods.