Patents by Inventor Marcus A. Tius

Marcus A. Tius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cryptophycins from synthesis
    Patent number: 6013626
    Abstract: A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals. It is a further object of this invention to use cryptophycins to inhibit the proliferation of mammalian cells. Moreover, methods of using cryptophycins to treat neoplasia is also provided.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: January 11, 2000
    Assignees: The University of Hawaii, Wayne State University
    Inventors: Richard E. Moore, Marcus A. Tius, Russell A. Barrow, Jian Liang, Thomas H. Corbett, Frederick A. Valeriote, Trimurtulu Golakoti, Thomas K. Hemscheidt
  • Synthesis of carboxylic acid glucuronides
    Patent number: 5633357
    Abstract: A method of producing a carboxylic acid glucuronide by reacting a carboxylic acid precursor with a blocked sugar epoxide precursor is disclosed. Also disclosed are: deuterated 11-nor-.DELTA..sup.8 - or .DELTA..sup.9 -THC carboxylic acid glucuronide having a deuterated hydrocarbon chain; 5'-deuterated 11-nor-.DELTA..sup.8 - or .DELTA..sup.9 -THC-carboxylic acid or 5'-deuterated .DELTA..sup.8 - or .DELTA..sup.9 -THC glucuronide. The compositions are useful as GC-MS standards; in methods for preparing antibodies reactive with a THC glucuronide; and, in GC-MS diagnostic methods for THC metabolites.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: May 27, 1997
    Assignee: Synthetic Technology Corporation
    Inventors: Marcus A. Tius, Mark R. Hagadone
  • Cyclic anti-tumor promoter compounds, compositions and methods for production and use
    Patent number: 5349112
    Abstract: Novel cyclic anti-tumor promoter compounds and therapeutic compositions are disclosed, along with method for their production and use as anti-cancer and cancer-prevention agents.
    Type: Grant
    Filed: November 26, 1993
    Date of Patent: September 20, 1994
    Assignee: University of Hawaii
    Inventor: Marcus A. Tius
  • Synthesis of 11-nor-.DELTA.-9-tetrahydrocannabinol-9-carboxylic acid glucuronide
    Patent number: 5292899
    Abstract: A method of producing a deuterated or undeuterated 11-nor-.DELTA..sup.8 -tetrahydrocannabinol (THC) glucuronide or deuterated or undeuterated 11-nor-.DELTA..sup.9 -THC glucuronide by reacting a blocked THC carboxylic acid precursor with a blocked sugar epoxide precursor is disclosed. Also disclosed are: deuterated 11-nor-.DELTA..sup.8 - or .DELTA..sup.9 -THC carboxylic acid glucuronide having a deuterated hydrocarbon chain; 5'-deuterated 11-nor-.DELTA..sup.8 - or .DELTA..sup.9 -THC-carboxylic acid or 5'-deuterated .DELTA..sup.8 - or .DELTA..sup.9 -THC glucuronide. The compositions are useful as GC-MS standards; in methods for preparing antibodies reactive with a THC glucuronide; and, in GC-MS diagnostic methods for THC metabolites.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: March 8, 1994
    Assignee: Synthetic Technology Corporation
    Inventors: Marcus A. Tius, Mark R. Hagadone
  • Cyclic anti-tumor promoter compounds, compositions and methods for production and use
    Patent number: 5276217
    Abstract: Novel cyclic anti-tumor promoter compounds and therapeutic compositions are disclosed, along with method for their production and use as anti-cancer and cancer-prevention agents.
    Type: Grant
    Filed: March 19, 1992
    Date of Patent: January 4, 1994
    Assignee: University of Hawaii
    Inventor: Marcus A. Tius